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公开(公告)号：US11083571B2
公开(公告)日：2021-08-10
申请号：US16442165
申请日：2019-06-14
发明人： Boaz Manash , Khen Perlmutter , Adi Carmi , Noa Axelrod , Nikolay Gurovich
IPC分类号： A61F2/24
摘要： A prosthetic heart valve is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The heart valve includes an annular inner frame formed with a plurality of angled first strut members, the inner frame being configured to foreshorten from a first length corresponding to the collapsed configuration to a second length corresponding to the expanded configuration. A leaflet structure is situated at least partially within the inner frame. An outer frame is disposed radially outward of the inner frame and coupled to the inner frame. The outer frame is configured to collapse with the inner frame and radially expand with the inner frame, and includes a plurality of second strut members. Portions of the second strut members are configured to bend radially outwardly into a curved shape as the inner frame and the outer frame move from the collapsed configuration to the expanded configuration.
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公开(公告)号：US20210361417A1
公开(公告)日：2021-11-25
申请号：US17397727
申请日：2021-08-09
IPC分类号： A61F2/24
摘要： A method of treating mitral valve stenosis in a human heart includes advancing a delivery apparatus through a right femoral vein, across a septal wall, and through a calcified mitral valve. A prosthetic heart valve is provided along a distal end portion of the delivery apparatus, wherein the prosthetic heart valve includes a metallic frame having a plurality of tissue-engaging elements positioned along an exterior surface and a leaflet structure for replacing the function of the calcified mitral valve. The prosthetic heart valve is radially expanded within an annulus of the calcified mitral valve such that at least some of the tissue-engaging elements of the prosthetic heart valve embed into the annulus. After radial expansion, the prosthetic heart valve is retained in position within the annulus via the tissue-engaging element and the leaflet structure replaces the function of the native mitral valve.
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公开(公告)号：US20200060811A1
公开(公告)日：2020-02-27
申请号：US16673660
申请日：2019-11-04
发明人： Darshin S. Patel , Boaz Manash , Khen Perlmutter , Yoav Rozen , Dinesh L. Sirimanne , Zohar Kiblitski , Noa Axelrod
IPC分类号： A61F2/24
摘要： Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.
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公开(公告)号：US10463479B2
公开(公告)日：2019-11-05
申请号：US15682287
申请日：2017-08-21
发明人： Boaz Manash , Darshin S. Patel , Khen Perlmutter , Yoav Rozen , Dinesh L. Sirimanne , Zohar Kiblitski , Noa Axelrod
IPC分类号： A61F2/24 , A61B17/00 , A61B17/064
摘要： Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.
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公开(公告)号：US20180055628A1
公开(公告)日：2018-03-01
申请号：US15682287
申请日：2017-08-21
发明人： Darshin S. Patel , Boaz Manash , Khen Perlmutter , Eyal Leiba , Yoav Rozen , Dinesh L. Sirimanne
IPC分类号： A61F2/24
摘要： Anchoring or docking devices configured to be positioned at a native valve of a human heart and to provide structural support for docking a prosthetic valve therein. The docking devices can have coiled structures that define an inner space in which the prosthetic valve can be held. The docking devices can have enlarged end regions with circular or non-circular shapes, for example, to facilitate implantation of the docking device or to better hold the docking device in position once deployed. The docking devices can be laser-cut tubes with locking wires to assist in better maintaining a shape of the docking device. The docking devices can include various features to promote friction, such as frictional cover layers. Such docking devices can have ends configured to more securely attach the cover layers to cores of the docking devices.
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公开(公告)号：US20230310152A1
公开(公告)日：2023-10-05
申请号：US18330252
申请日：2023-06-06
发明人： Darshin S. Patel , Boaz Manash , Khen Perlmutter , Eyal Leiba , Yoav Rozen , Dinesh L. Sirimanne , Tri D. Tran , Jocelyn Chau , Noa Axelrod Manela , Zohar Kiblitski
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2466 , A61F2/2463
摘要： A docking device for docking a prosthetic valve at a native valve of a heart can include a coil comprising a plurality of turns and having a proximal end and distal end. The docking device can further include a first covering disposed around and covering the coil from the distal end to the proximal end of the coil, and a second covering disposed over the first covering. A distal end and proximal end of the second covering are spaced away from a distal end and proximal end, respectively, of the first covering.
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公开(公告)号：US20220257367A1
公开(公告)日：2022-08-18
申请号：US17732985
申请日：2022-04-29
发明人： Yair A. Neumann , Oren Cohen , Khen Perlmutter , Eitan Atias , Noam Miller , Eran Goldberg , Anatoly Dvorsky , Tamir S. Levi , Haim Yushtein , Danny M. Garmahi , Ziv Yohanan , Michael Bukin , Noam Nir , Elena Sherman , Gideon Sagi
IPC分类号： A61F2/24
摘要： An implantable prosthetic valve can include a frame movable between a radially compressed and a radially expanded configuration. The frame can include a first strut having a first locking feature disposed on a radially facing inner surface of the strut and a second strut having a second locking feature disposed on a radially facing outer surface of the strut. The first and second locking features can engage each other so as to allow pivoting of the first and second struts relative to one another in a first direction upon radial expansion of the frame and resist pivoting of the first and second struts relative to one another in a second direction to resist radial compression of the frame.
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公开(公告)号：US20200000579A1
公开(公告)日：2020-01-02
申请号：US16442165
申请日：2019-06-14
发明人： Boaz Manash , Khen Perlmutter , Adi Carmi , Noa Axelrod , Nikolay Gurovich
IPC分类号： A61F2/24
摘要： A prosthetic heart valve is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The heart valve includes an annular inner frame formed with a plurality of angled first strut members, the inner frame being configured to foreshorten from a first length corresponding to the collapsed configuration to a second length corresponding to the expanded configuration. A leaflet structure is situated at least partially within the inner frame. An outer frame is disposed radially outward of the inner frame and coupled to the inner frame. The outer frame is configured to collapse with the inner frame and radially expand with the inner frame, and includes a plurality of second strut members. Portions of the second strut members are configured to bend radially outwardly into a curved shape as the inner frame and the outer frame move from the collapsed configuration to the expanded configuration.
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公开(公告)号：US20180177594A1
公开(公告)日：2018-06-28
申请号：US15902956
申请日：2018-02-22
发明人： Darshin S. Patel , Boaz Manash , Khen Perlmutter , Eyal Leiba , Yoav Rozen , Dinesh L. Sirimanne , Tri D. Tran , Jocelyn Chau , Noa Axelrod , Zohar Kiblitski
IPC分类号： A61F2/24
摘要： Docking devices for docking a prosthetic valve at a native valve of a heart can include a coiled docking anchor and a retrieval suture. The docking device and retrieval suture can be configured for improved retention and retrieval of the docking device after deployment. The docking devices can have an end portion with a central axis. The retrieval suture can be connected to the end portion such that a line of force applied by applying tension to the retrieval suture is substantially aligned with the central axis.
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公开(公告)号：US20240189098A1
公开(公告)日：2024-06-13
申请号：US18443128
申请日：2024-02-15
发明人： Sara Tzadok , Khen Perlmutter , Darshin S. Patel , Boaz Manash , Ajay Chadha , Waina Michelle Chu , Chambory Chhe , Evan T. Schwartz , Sandip Vasant Pawar
CPC分类号： A61F2/2412 , A61F2/0077 , A61F2/2409 , A61F2/2418 , A61F2002/0086 , A61F2/243 , A61F2210/0076
摘要： A prosthetic heart valve has a frame including a plurality of strut members, the frame being radially expandable and collapsible between a collapsed state and an expanded state, the frame having an inflow end and an outflow end and defining a longitudinal axis. A leaflet structure is situated at least partially within the frame. A covering is disposed around an exterior of the frame and includes a cushioning layer, a first strip of material coupled to the cushioning layer and folded to encapsulate apices of the strut members of the inflow end of the frame, and a second strip of material coupled to the cushioning layer and folded to encapsulate apices of the strut members of the outflow end of the frame. The cushioning layer includes texturized filaments that provide compressible volume and a plush surface to the cushioning layer when the frame is in the expanded state.
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