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公开(公告)号:US09481669B2
公开(公告)日:2016-11-01
申请号:US14710687
申请日:2015-05-13
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim
IPC分类号: C07D405/06 , C07D405/14 , A61K31/496
CPC分类号: C07D405/14 , C07D405/06
摘要: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译: 本发明提供新颖的扁桃苷内酰吡啶化合物,含有这些化合物的药物组合物,以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症,特别是癌症,其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号:US20190100513A1
公开(公告)日:2019-04-04
申请号:US15529798
申请日:2016-11-17
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号: C07D405/14 , A61P35/02
摘要: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号:US10745387B2
公开(公告)日:2020-08-18
申请号:US15529798
申请日:2016-11-17
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号: A61K31/496 , C07D295/182 , C07D405/14 , C07D405/06 , A61P35/02
摘要: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号:US20150329528A1
公开(公告)日:2015-11-19
申请号:US14710687
申请日:2015-05-13
发明人: Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai
IPC分类号: C07D405/14 , C07D405/06
CPC分类号: C07D405/14 , C07D405/06
摘要: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译: 本发明提供新颖的扁桃苷内酰吡啶化合物,含有这些化合物的药物组合物,以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症,特别是癌症,其中靶向剪接体的试剂和其中的突变已知是有用的。
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