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公开(公告)号：US11926619B2
公开(公告)日：2024-03-12
申请号：US17045952
申请日：2019-04-08
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Lisa A. Marcaurelle , Marta Nevalainen , Ming-Hong Hao , Morgan Welzel O'Shea , Parcharee Tivitmahaisoon , Sudeep Prajapati , Tuoping Luo , Nicholas C. Gearhart , Jason T. Lowe , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Andrew Cook , Shelby Ellery , Atsushi Endo , James Palacino , Dominic Reynolds
IPC分类号： C07D407/12 , A61K31/365 , A61K31/4427 , A61K31/497 , A61K45/06 , A61P35/00 , C07D313/00 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D487/10 , C07D491/107
CPC分类号： C07D407/06 , A61K45/06 , A61P35/00 , C07D313/00 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D487/10 , C07D491/107
摘要： The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
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公开(公告)号：US09481669B2
公开(公告)日：2016-11-01
申请号：US14710687
申请日：2015-05-13
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim
IPC分类号： C07D405/06 , C07D405/14 , A61K31/496
CPC分类号： C07D405/14 , C07D405/06
摘要： The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译： 本发明提供新颖的扁桃苷内酰吡啶化合物，含有这些化合物的药物组合物，以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症，特别是癌症，其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号：US20210261566A1
公开(公告)日：2021-08-26
申请号：US17167480
申请日：2021-02-04
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61K39/395 , A61K31/357 , C07K16/28 , A61P35/00
摘要： The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.
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公开(公告)号：US20200325152A1
公开(公告)日：2020-10-15
申请号：US16764245
申请日：2018-11-15
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61P35/04
摘要： The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.
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公开(公告)号：US20200148698A1
公开(公告)日：2020-05-14
申请号：US16500924
申请日：2018-04-03
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61K31/357 , A61K39/395 , A61P35/00 , C07K16/28
摘要： The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable and medical uses thereof.
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公开(公告)号：US20150329528A1
公开(公告)日：2015-11-19
申请号：US14710687
申请日：2015-05-13
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai
IPC分类号： C07D405/14 , C07D405/06
CPC分类号： C07D405/14 , C07D405/06
摘要： The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译： 本发明提供新颖的扁桃苷内酰吡啶化合物，含有这些化合物的药物组合物，以及使用该化合物作为治疗剂的方法。 这些化合物可用于治疗癌症，特别是癌症，其中靶向剪接体的试剂和其中的突变已知是有用的。
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公开(公告)号：US11725015B2
公开(公告)日：2023-08-15
申请号：US17167480
申请日：2021-02-04
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61P35/00 , A61K31/357 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07D493/22 , A61K31/357 , A61K39/3955 , A61P35/00 , C07K16/2818 , C07K16/2863 , A61K2039/505 , A61K2300/00
摘要： The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, and medical uses thereof.
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公开(公告)号：US20190100513A1
公开(公告)日：2019-04-04
申请号：US15529798
申请日：2016-11-17
发明人： Gregg F. Keaney , John Wang , Baudouin Gerard , Kenzo Arai , Xiang Liu , Guo Zhu Zheng , Kazunobu Kira , Parcharee Tivitmahaisoon , Sudeep Prajapati , Nicholas C. Gearhart , Yoshihiko Kotake , Satoshi Nagao , Regina Mikie Kanada Sonobe , Masayuki Miyano , Norio Murai , Silvia Buonamici , Lihua Yu , Eunice Sun Park , Betty Chan , Peter G. Smith , Michael P. Thomas , Ermira Pazolli , Kian Huat Lim , Atsushi Endo , Arani Chanda
IPC分类号： C07D405/14 , A61P35/02
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号：US20240309014A1
公开(公告)日：2024-09-19
申请号：US18480929
申请日：2023-10-04
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61P35/04
CPC分类号： C07D493/22 , A61P35/04
摘要： The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.
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公开(公告)号：US11407762B2
公开(公告)日：2022-08-09
申请号：US16764245
申请日：2018-11-15
发明人： Yoshito Kishi , Kazunobu Kira , Ken Ito
IPC分类号： C07D493/22 , A61P35/04
摘要： The present invention provides novel compounds (e.g., compounds of Formulae (I), (II), (III), (IV)) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or pharmaceutically acceptable salts thereof, optionally in a pharmaceutically acceptable carrier, and a medical uses thereof.
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