-
![ANTI-WOLBACHIA PYRIDO[2,3-d]PYRIMIDINECOMPOUNDS](/abs-image/US/2023/11/02/US20230348460A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230348460A1
公开(公告)日：2023-11-02
申请号：US17956435
申请日：2022-09-29
Applicant: Liverpool School of Tropical Medicine , The University of Liverpool , Eisai R&D Management Co., Ltd.
Inventor： Stephen A. Ward , Mark J. Taylor , Paul M. O’Neil , Weiqian David Hong , Farid Benayoud
IPC: C07D471/04 , C07D239/86 , C07D495/04
CPC classification number: C07D471/04 , C07D239/86 , C07D495/04
Abstract: The present invention relates to compounds of Formulae I and II as defined herein, and salts and solvates thereof.
The present invention also relates to pharmaceutical compositions comprising compounds of Formulae I and II, and to the use of compounds of Formulae I and II in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.-
公开(公告)号：US20180044285A1
公开(公告)日：2018-02-15
申请号：US15791814
申请日：2017-10-24
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Toshiaki Tanaka , Keiichi Sorimachi
IPC: C07C309/73 , C12P7/22 , C07C309/66 , C07C303/28 , C07C33/50 , C07D239/34 , C07D401/12 , C07C69/16 , C07C303/44 , C07C29/147
CPC classification number: C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50
Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
-
3.发明授权Methods and compounds useful in the synthesis of orexin-2 receptor antagonists 有权用于合成食欲肽-2受体拮抗剂的方法和化合物公开(公告)号：US09416109B2
公开(公告)日：2016-08-16
申请号：US14379063
申请日：2013-02-14
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Jaemoon Lee , Huiming Zhang , Taro Terauchi , Ayumi Takemura , Yu Yoshida , Toshiaki Tanaka , Keiichi Sorimachi , Yoshimitsu Naoe , Yuji Kazuta
IPC: C07D239/34 , C07C69/16 , C07C309/66 , C12P7/22 , C07C309/73 , C07D401/12 , C07C303/28 , C07C29/147
CPC classification number: C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50
Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
Abstract translation: 本公开提供了可用于制备可用作食欲素-2受体拮抗剂的化合物的化合物和方法。
-
公开(公告)号：USRE47797E1
公开(公告)日：2020-01-07
申请号：US15944480
申请日：2018-04-03
Applicant: EISAI R&D MANAGEMENT CO., LTD.
Inventor： Farid Benayoud , Trevor Lee Calkins , Charles E. Chase , William Christ , Bryan M. Lewis , Matthew Schnaderbeck , Marc Pesant , Brian Austad , Silvio Campagna , Yongbo Hu , Gordon Wilkie , Xiaojie Zhu , Francis G. Fang
IPC: C07D307/28 , C07F7/18 , C07C33/42 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C07D493/18 , C07D493/22 , C07D493/20 , C07D317/72 , C07H15/26 , A61K31/341 , C07D307/12 , C07D493/10 , C07D307/33
Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
-
公开(公告)号：US09828336B2
公开(公告)日：2017-11-28
申请号：US15158687
申请日：2016-05-19
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Toshiaki Tanaka , Keiichi Sorimachi
IPC: C07C309/73 , C07C303/44 , C07C309/66 , C07C69/16 , C12P7/22 , C07D401/12 , C07D239/34 , C07C303/28 , C07C29/147
CPC classification number: C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50
Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
-
Patent Agency Ranking
6.发明申请METHODS AND COMPOUNDS USEFUL IN THE SYNTHESIS OF OREXIN-2 RECEPTOR ANTAGONISTS 审中-公开合成OREXIN-2受体拮抗剂的方法和化合物公开(公告)号：US20160318858A1
公开(公告)日：2016-11-03
申请号：US15158687
申请日：2016-05-19
Applicant: Eisai R&D Management Co., Ltd.
Inventor： George Anthony Moniz , Annie Zhu Wilcoxen , Farid Benayoud , Toshiaki Tanaka , Keiichi Sorimachi
IPC: C07C309/73 , C07C303/44 , C12P7/22 , C07C303/28
CPC classification number: C07C309/73 , C07B2200/07 , C07C29/147 , C07C69/16 , C07C303/28 , C07C303/44 , C07C309/66 , C07C2601/02 , C07D239/34 , C07D401/12 , C12P7/22 , C07C33/50
Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
Abstract translation: 本公开提供了可用于制备可用作食欲素-2受体拮抗剂的化合物的化合物和方法。
-
公开(公告)号：US20150232490A1
公开(公告)日：2015-08-20
申请号：US14624171
申请日：2015-02-17
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Farid Benayoud , Trevor Lee Calkins , Charles E. Chase , William Christ
IPC: C07F7/18 , C07D307/28 , C07C33/42
CPC classification number: C07F7/1804 , A61K31/341 , C07C33/423 , C07D307/12 , C07D307/28 , C07D307/33 , C07D317/72 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C07D493/10 , C07D493/18 , C07D493/20 , C07D493/22 , C07F7/188 , C07H15/26 , Y02P20/55
Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
Abstract translation: 提供了中间体及其在合成类软绵母B合成中的应用方法。
-
公开(公告)号：US20250051285A1
公开(公告)日：2025-02-13
申请号：US18719032
申请日：2022-12-22
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Farid Benayoud
IPC: C07D231/20 , A61K31/415
Abstract: A crystalline free acid form of (S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid is provided. Methods of making and using the crystalline free acid form of (S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid are also provided.
-
![Anti-Wolbachia pyrido[2,3-d]pyrimidine compounds](/abs-image/US/2022/12/06/US11518760B2/abs.jpg.150x150.jpg)
公开(公告)号：US11518760B2
公开(公告)日：2022-12-06
申请号：US16478281
申请日：2018-01-17
Applicant: Liverpool School of Tropical Medicine , The University of Liverpool , Eisai R&D Management Co., Ltd.
Inventor： Stephen A. Ward , Mark J. Taylor , Paul M. O'Neill , Weiqian David Hong , Farid Benayoud
IPC: C07D471/04 , C07D239/86 , C07D495/04
Abstract: The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.
-
公开(公告)号：US09303050B2
公开(公告)日：2016-04-05
申请号：US14624171
申请日：2015-02-17
Applicant: Eisai R&D Management Co., Ltd.
Inventor： Farid Benayoud , Trevor Lee Calkins , Charles E. Chase , William Christ
IPC: C07D307/28 , C07F7/18 , C07C33/42
CPC classification number: C07F7/1804 , A61K31/341 , C07C33/423 , C07D307/12 , C07D307/28 , C07D307/33 , C07D317/72 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C07D493/10 , C07D493/18 , C07D493/20 , C07D493/22 , C07F7/188 , C07H15/26 , Y02P20/55
Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.024 seconds)
