公开(公告)号：US09744487B2

公开(公告)日：2017-08-29

申请号：US14493678

申请日：2014-09-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B01D61/20 ,  B01D61/30 ,  B30B7/00 ,  B30B9/22 ,  C12M1/12 ,  C12M3/06 ,  B01D33/00 ,  B01D61/18 ,  F04B43/08 ,  A61M1/16 ,  B01D15/08 ,  B01D61/24 ,  C12M1/00

CPC classification number: B01D33/00 ,  A61M1/16 ,  B01D15/08 ,  B01D61/18 ,  B01D61/20 ,  B01D61/243 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/18 ,  B01D2313/58 ,  C12M47/12 ,  F04B43/08 ,  Y10T16/522 ,  Y10T137/8593 ,  Y10T137/86187 ,  Y10T137/86196

Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first she (16) disposed on a front face (5) of said base (2) and a second shed (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

公开(公告)号：US20150020366A1

公开(公告)日：2015-01-22

申请号：US14506946

申请日：2014-10-06

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B23P19/04

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管和机械连接，其包括相对于歧管可移动地安装的夹板，并且适于将至少一个盒压靠在歧管上，用于驱动和引导夹板的装置， 所述歧管和所述板，致动器，其设置有主体和可相对于所述主体移动的构件，所述构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由所述歧管承载，并且所述主体 承载杆并且通过杆将板驱动到夹紧位置，在该夹紧位置处，构件处于中间缩回位置，在该夹紧位置中，其已经相对于其延伸位置移动比预定行程更短的行程。

公开(公告)号：US08506798B2

公开(公告)日：2013-08-13

申请号：US13688255

申请日：2012-11-29

Applicant: EMD Millipore Corporation

Inventor： Jean-Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: B01D36/00 ,  C12M1/12 ,  C12M1/00

CPC classification number: B01D36/00 ,  C12M1/12 ,  C12M47/12 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).

公开(公告)号：US20130087490A1

公开(公告)日：2013-04-11

申请号：US13688255

申请日：2012-11-29

Applicant: EMD Millipore Corporation

Inventor： Jean-Luc Beulay ,  Virginie Buisson ,  Sebastien Cirou ,  Cecile Delbos ,  Marc Hlavacek ,  Frans Mels ,  Rene Reinbigler ,  Jean-Louis Weissenbach

IPC: B01D36/00

CPC classification number: B01D36/00 ,  C12M1/12 ,  C12M47/12 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).

Abstract translation: 用于处理包括循环泵（5），过滤元件（9），用于收集处理液体的容器的生物液体的安装，将所述生物液体源连接到所述过滤元件（9）的入口孔的第一回路段 ），包括适于与所述循环泵（5）配合的电路元件; 第二电路部分，将所述过滤元件（9）的出口孔连接到所述处理过的液体收集容器; 其特征在于，所述处理过的液体收集容器，所述第一回路部分和所述第二回路部分是一次性的，并且所述装置还包括承载所述泵（5）的第一推车（1）和包括壳体（14）的第二推车（2） 用于所述收集容器，所述收集容器可与所述第一推车（1）分离并且适于至少部分地嵌套在所述第一推车（1）中。

公开(公告)号：US20210253994A1

公开(公告)日：2021-08-19

申请号：US17262957

申请日：2019-05-15

Applicant: EMD Millipore Corporation

Inventor： Laurent Jourdainne ,  Sebastien Cirou

IPC: C12M1/34 ,  C12M1/12 ,  C12M3/00

Abstract: The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve (4) for suppling biological liquid to treat, a first line (2) downstream of said valve and provided with a first main tank (7), a second line (3) downstream of said valve and provided with a second main tank (14), said second line being in parallel with said first line, and a third main tank (11) disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.

公开(公告)号：US09677675B2

公开(公告)日：2017-06-13

申请号：US14413556

申请日：2013-07-18

Applicant: EMD Millipore Corporation

Inventor： Ronald Tuccelli ,  Sebastien Cirou ,  Virginie Buisson ,  Christine Abouayad El Idrissi ,  Jim Kelly

IPC: F16K7/04 ,  F16K7/06 ,  F16K7/12 ,  B01L99/00 ,  B01L3/00 ,  B29C49/00 ,  B29L31/14

Abstract: The invention concerns a circuit comprising a bag (11) comprising two flexible films (45, 46) and a press (10) comprising a first (14) and a second (13) shell clamping the bag to form pipes having a passage and edges (41); the first shell comprising a valve (20) which comprises a movable member (24) and a pad (31), which pad has a resting configuration in which a second face (33) of the pad is concave and locally delimits a channel (18) and a pinching configuration in which the second face (33) is convex; said movable member and said pad being configured so that, when said valve is in closed position and said pad in pinching configuration, said passage is pinched by said movable member against said second shell channel and said edges (41) are pinched flat by said movable member against said second shell (13).

公开(公告)号：US09676069B2

公开(公告)日：2017-06-13

申请号：US14311399

申请日：2014-06-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/12 ,  B01D25/127 ,  B01D25/164 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B23P19/04 ,  B01D25/19

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

公开(公告)号：US09573230B2

公开(公告)日：2017-02-21

申请号：US14506946

申请日：2014-10-06

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Jean-Louis Weissenbach ,  Rene Reinbigler ,  Jean-Luc Beulay ,  Frans Mels ,  Cecile Delbos

IPC: B01D25/12 ,  B01D25/127 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/08 ,  B23P19/04

CPC classification number: B23P19/04 ,  B01D25/127 ,  B01D25/14 ,  B01D25/164 ,  B01D25/19 ,  B01D61/18 ,  B01D61/20 ,  B01D63/082 ,  B01D2313/02 ,  B01D2313/06 ,  B01D2313/105 ,  B01D2313/125 ,  Y10T29/49826

Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.

Abstract translation: 本发明涉及一种过滤装置，其包括提供流体连接的歧管和机械连接，其包括相对于歧管可移动地安装的夹板，并且适于将至少一个盒压靠在歧管上，用于驱动和引导夹板的装置， 所述歧管和所述板，致动器，其设置有主体和可相对于所述主体移动的构件，所述构件适于在延伸位置和缩回位置之间移动通过预定行程，所述主体由所述歧管承载，并且所述主体 承载杆并且通过杆将板驱动到夹紧位置，在该夹紧位置处，构件处于中间缩回位置，在该夹紧位置中，其已经相对于其延伸位置移动比预定行程更短的行程。

公开(公告)号：US20150013773A1

公开(公告)日：2015-01-15

申请号：US14493858

申请日：2014-09-23

Applicant: EMD Millipore Corporation

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: F17D1/00

CPC classification number: F17D1/00 ,  B01D61/18 ,  B01D61/20 ,  B01D61/30 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/58 ,  B30B7/00 ,  B30B9/22 ,  C12M47/12 ,  F04B43/08 ,  Y10T137/0318 ,  Y10T137/8593

Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.

Abstract translation: 本发明涉及一种装置，包括：基座（2）; 一个可移动或可拆卸的门（20），所述装置具有一个闭合的门位置; 并且在关闭的门位置，包括包括两个柔性膜和传送网络连接器的袋的电路（8）和包括设置在所述基座（2）的所述前表面（5）上的第一壳体（16）的压力机（9） ）和设置在所述门（20）中的第二壳（17）; 所述袋被夹在所述第一壳体（16）和所述第二壳体（17）之间，在所述薄膜之间形成用于输送液体的所述网络的导管的状态。

公开(公告)号：US11970687B2

公开(公告)日：2024-04-30

申请号：US17262957

申请日：2019-05-15

Applicant: EMD Millipore Corporation

Inventor： Laurent Jourdainne ,  Sebastien Cirou

IPC: C12M1/34 ,  C12M1/12 ,  C12M3/00

CPC classification number: C12M41/26 ,  C12M23/44 ,  C12M37/00

Abstract: The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve (4) for suppling biological liquid to treat, a first line (2) downstream of said valve and provided with a first main tank (7), a second line (3) downstream of said valve and provided with a second main tank (14), said second line being in parallel with said first line, and a third main tank (11) disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.