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公开(公告)号：US11623215B2
公开(公告)日：2023-04-11
申请号：US16607743
申请日：2018-05-10
Applicant: EMD Millipore Corporation
Inventor： Phillip Clark , Kurt E. Greenizen , John Doyle
Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.
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公开(公告)号：US20190111395A1
公开(公告)日：2019-04-18
申请号：US16094237
申请日：2017-04-20
Applicant: EMD Millipore Corporation
Inventor： Kurt E. Greenizen , Christopher A. Scott , Paul Sydlowski , John Doyle , Ryan A. Amara
Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
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公开(公告)号：US10088398B2
公开(公告)日：2018-10-02
申请号：US14994402
申请日：2016-01-13
Applicant: EMD Millipore Corporation
Inventor： Phillip Clark , Kurt Greenizen , John Doyle
Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.
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公开(公告)号：US20200330981A1
公开(公告)日：2020-10-22
申请号：US16607743
申请日：2018-05-10
Applicant: EMD Millipore Corporation
Inventor： Phillip Clark , Kurt E. Greenizen , John Doyle
Abstract: Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.
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公开(公告)号：US20180372600A1
公开(公告)日：2018-12-27
申请号：US16115762
申请日：2018-08-29
Applicant: EMD Millipore Corporation
Inventor： Phillip Clark , Kurt Greenizen , John Doyle
Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.
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Patent Agency Ranking
公开(公告)号：US09295947B2
公开(公告)日：2016-03-29
申请号：US14190560
申请日：2014-02-26
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
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公开(公告)号：USD946167S1
公开(公告)日：2022-03-15
申请号：US29755024
申请日：2020-10-16
Applicant: EMD Millipore Corporation
Designer： Paul Sydlowski , John Doyle
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公开(公告)号：US20140224723A1
公开(公告)日：2014-08-14
申请号：US14190560
申请日：2014-02-26
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。
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公开(公告)号：US08747670B2
公开(公告)日：2014-06-10
申请号：US13649365
申请日：2012-10-11
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。
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公开(公告)号：US11433355B2
公开(公告)日：2022-09-06
申请号：US16094237
申请日：2017-04-20
Applicant: EMD Millipore Corporation
Inventor： Kurt E. Greenizen , Christopher A. Scott , Paul Sydlowski , John Doyle , Ryan A. Amara
IPC: B01L9/00 , B01D63/08 , B25B5/04 , B25B5/08 , B25B5/06 , B01L3/00 , B25B5/14 , G01N1/40 , B25B7/14
Abstract: A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
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