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公开(公告)号：US09295947B2
公开(公告)日：2016-03-29
申请号：US14190560
申请日：2014-02-26
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
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Patent Agency Ranking
公开(公告)号：US20140224723A1
公开(公告)日：2014-08-14
申请号：US14190560
申请日：2014-02-26
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。
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公开(公告)号：US08747670B2
公开(公告)日：2014-06-10
申请号：US13649365
申请日：2012-10-11
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。
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公开(公告)号：US20220323300A1
公开(公告)日：2022-10-13
申请号：US17639973
申请日：2020-09-09
Applicant: James DEE , George GAGNE , Daniel LAMOTHE , EMD Millipore Corporation
Inventor： Shannon Cleveland , Marina Varlamova , John Saragosa , David DeCoste , Benjamin Cacace , Daniel Lamothe , George Gagne , James Dee , Wilson Moya , Stefano Berti Perez
Abstract: A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.
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公开(公告)号：US09050565B2
公开(公告)日：2015-06-09
申请号：US13739008
申请日：2013-01-11
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
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公开(公告)号：US20130186830A1
公开(公告)日：2013-07-25
申请号：US13739008
申请日：2013-01-11
Applicant: EMD Millipore Corporation
Inventor： Louis Bonhomme , John Doyle , Kurt Greenizen , George Gagne , Sean Devin , Gerard Lombard , Vincent Smith
IPC: B01D63/16
CPC classification number: B01D63/16 , B01D61/145 , B01D61/18 , B01D63/08 , B01D2313/08 , B01L3/502 , B01L3/5021 , B01L3/5635 , B01L2300/0681
Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.
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