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公开(公告)号：US09891218B2
公开(公告)日：2018-02-13
申请号：US15006153
申请日：2016-01-26
发明人： Chris Scott , Phillip Clark , Kurt E. Greenizen , Ryan A. Amara , Robert Colonna
IPC分类号： G01N21/75 , G01N33/558 , G01N33/543 , B01L3/00 , B01L9/00 , G01N33/569 , B01J20/28
CPC分类号： G01N33/558 , B01J20/28033 , B01J20/28035 , B01J20/2804 , B01L3/5023 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0681 , B01L2300/069 , B01L2300/0809 , B01L2300/12 , B01L2300/126 , B01L2400/0487 , B01L2400/049 , G01N33/54366 , G01N33/56911 , G01N2469/10 , G01N2469/20
摘要： The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.
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公开(公告)号：US20160178625A1
公开(公告)日：2016-06-23
申请号：US15006153
申请日：2016-01-26
发明人： Chris Scott , Phillip Clark , Kurt E. Greenizen , Ryan A. Amara , Robert Colonna
IPC分类号： G01N33/558 , B01L9/00 , B01L3/00
CPC分类号： G01N33/558 , B01J20/28033 , B01J20/28035 , B01J20/2804 , B01L3/5023 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0681 , B01L2300/069 , B01L2300/0809 , B01L2300/12 , B01L2300/126 , B01L2400/0487 , B01L2400/049 , G01N33/54366 , G01N33/56911 , G01N2469/10 , G01N2469/20
摘要： The embodiments disclosed herein are directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the blotting membrane(s), a flow distributor above the blotting membrane(s) and optionally a well on the flow distributor to contain the liquid to the desired area and to allow for lower starting volumes of such liquid. Preferably, the flow distributor is a non-binding or low binding hydrophilic porous membrane such as a 0.22 micron membrane and the support layer is a grid or sintered porous material. The distributor and support are held together to form an envelope around the membrane(s). The use of a hinge, clips and other such devices is preferred in doing so.
摘要翻译： 本文公开的实施方案涉及用于在印迹膜上进行化合物检测的装置。 该装置包括多个层，包括印迹膜下面的多孔支撑层，印迹膜上方的流量分布器，以及任选的流量分配器上的孔，以将液体包含到期望的区域并允许 降低这种液体的起始体积。 优选地，流动分配器是非结合或低结合的亲水性多孔膜，例如0.22微米的膜，并且支撑层是格栅或烧结的多孔材料。 分配器和支撑件保持在一起以在膜周围形成一个信封。 在这样做时优选使用铰链，夹子和其它这样的装置。
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公开(公告)号：US20200330981A1
公开(公告)日：2020-10-22
申请号：US16607743
申请日：2018-05-10
发明人： Phillip Clark , Kurt E. Greenizen , John Doyle
摘要： Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.
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公开(公告)号：USD792971S1
公开(公告)日：2017-07-25
申请号：US29563491
申请日：2016-05-05
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公开(公告)号：US11623215B2
公开(公告)日：2023-04-11
申请号：US16607743
申请日：2018-05-10
发明人： Phillip Clark , Kurt E. Greenizen , John Doyle
摘要： Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.
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公开(公告)号：US20190111395A1
公开(公告)日：2019-04-18
申请号：US16094237
申请日：2017-04-20
摘要： A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
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公开(公告)号：US20240192166A1
公开(公告)日：2024-06-13
申请号：US18533928
申请日：2023-12-08
发明人： Kurt E. Greenizen , Ryan Amara , Christopher A. Scott , Paul Sydlowski , Michael Miller , Kelly Wolfe
IPC分类号： G01N27/447
CPC分类号： G01N27/44743
摘要： A removal tool for sample well combs that is configured to aid in the extraction of a sample well comb from an electrophoresis gel. The removal tool may be either removably coupled to the sample well comb or may be permanently affixed to the sample well comb in order to provide a surface/region that is more easily graspable by a user to aid in the extraction of the sample well comb. The removal tool may include one or more engagement members that may be at least partially disposed within an opening of the sample well comb to couple the removal tool to the sample well comb. The removal tool may also include a mechanism that is configured to impart extraction forces to a surface in proximity to the sample well comb to further aid in the extraction of the sample well comb.
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公开(公告)号：US11433355B2
公开(公告)日：2022-09-06
申请号：US16094237
申请日：2017-04-20
IPC分类号： B01L9/00 , B01D63/08 , B25B5/04 , B25B5/08 , B25B5/06 , B01L3/00 , B25B5/14 , G01N1/40 , B25B7/14
摘要： A clamp including a first jaw member having a camming surface, a second jaw member pivotable with respect to the first jaw member, a first biasing member biasing the first and second jaw members to a first position; and a locking mechanism that includes a cam or roller for cooperating with the camming surface of the jaw member, and a second biasing member biasing the cam or roller against the camming surface to lock the first and second jaw members in a second position. An optional alignment collar can be used to align components of the filtration apparatus prior to clamping. Filtration apparatus including the clamp, and also optionally including the alignment collar, is also disclosed.
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