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    Centrifugal Filter
    2.
    发明申请
    Centrifugal Filter 有权
    离心过滤器

    公开(公告)号：US20140224723A1

    公开(公告)日：2014-08-14

    申请号：US14190560

    申请日：2014-02-26

    Applicant: EMD Millipore Corporation

    Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

    IPC: B01D63/16 ,  B01D61/14 ,  B01D61/18

    CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

    Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。

    Centrifugal filter
    3.
    发明授权
    Centrifugal filter 有权
    离心过滤器

    公开(公告)号：US08747670B2

    公开(公告)日：2014-06-10

    申请号：US13649365

    申请日：2012-10-11

    Applicant: EMD Millipore Corporation

    Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

    IPC: B01D63/08 ,  B01D63/16 ,  B01D61/18 ,  B01L3/00

    CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

    Abstract translation: 适用于浓缩液体样品，特别是生物分子的过滤装置，以及浓缩，脱盐，纯化和/或分馏液体样品的方法。 在某些实施方案中，该装置包括具有样品储存器的壳体和设置在壳体中的两个基本垂直定向和间隔开的膜。 与每个膜相关联的下划线，使得通过每个膜的流体通过相应的下划线流入滤液收集室。 不通过膜的流体被收集在滞留物收集室中，并且可以通过反转纺步骤回收，实现大于约90％的回收率。 膜的基本垂直取向将可用的膜面积增加了传统过滤装置中可用面积的至少2.7倍。 两面板配置在过滤的最后阶段比在单面板配置中还维持使用更多的可用膜面积。

    Stirred Cell And Method Of Using Same
    5.
    发明申请
    Stirred Cell And Method Of Using Same 审中-公开

    公开(公告)号：US20180372600A1

    公开(公告)日：2018-12-27

    申请号：US16115762

    申请日：2018-08-29

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: G01N1/40 ,  B01L3/00

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    Centrifugal filter
    6.
    发明授权
    Centrifugal filter 有权

    公开(公告)号：US09295947B2

    公开(公告)日：2016-03-29

    申请号：US14190560

    申请日：2014-02-26

    Applicant: EMD Millipore Corporation

    Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

    IPC: B01D61/18 ,  B01D63/16 ,  B01L3/00 ,  B01D63/08 ,  B01D61/14

    CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

    Stirred cell and method of using same
    8.
    发明授权
    Stirred cell and method of using same 有权

    公开(公告)号：US10088398B2

    公开(公告)日：2018-10-02

    申请号：US14994402

    申请日：2016-01-13

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: G01N1/40 ,  B01L3/00

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

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