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    Methods And Devices Used For Redundant Sterile Filtration
    2.
    发明申请
    Methods And Devices Used For Redundant Sterile Filtration 有权
    用于冗余无菌过滤的方法和设备

    公开(公告)号：US20150283479A1

    公开(公告)日：2015-10-08

    申请号：US14440370

    申请日：2013-11-26

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

    IPC: B01D19/00

    CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

    Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more in-puts for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

    Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，该阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络具有一个或多个投入物，用于将液体原料引入流体工艺流中，以及一个或多个输出端口，用于将流体排出流体工艺流。 网络优选是基本上封闭的网络，并且优选地是无菌和/或无菌的。

    DEVICE FOR BIND AND ELUTE CHROMATOGRAPHY USING MEMBRANES, AND METHOD OF MANUFACTURE
    3.
    发明申请
    DEVICE FOR BIND AND ELUTE CHROMATOGRAPHY USING MEMBRANES, AND METHOD OF MANUFACTURE 有权

    公开(公告)号：US20220032235A1

    公开(公告)日：2022-02-03

    申请号：US17432122

    申请日：2020-02-20

    Applicant: EMD Millipore Corporation

    Inventor： Kevin Rautio ,  Sean Foley ,  Stephen G. Hunt ,  Bumchul Lee ,  Nathan Landry

    IPC: B01D63/08

    Abstract: Single-use integral chromatography unit having an inlet and an outlet, and comprising one or more plates or pairs of filter plates interposable between a pair of end plates. In certain embodiments, each of the filter plates comprises a polymeric framework with one or more membranes supported therein. The filter plates and end plates may be assembled to form a substantially fixed, substantially water-tight, integral stack. Fluid entering the unit through a common inlet passes the membrane or membranes of each filter plate substantially contemporaneously prior to exiting the unit through a common outlet (cf, “parallel” flow). The assembly is a modular design, as multiple pairs of plates can be stacked in a suitable holder to form a single chromatography unit.

    Methods and devices used for redundant sterile filtration
    6.
    发明授权
    Methods and devices used for redundant sterile filtration 有权

    公开(公告)号：US10195544B2

    公开(公告)日：2019-02-05

    申请号：US15608102

    申请日：2017-05-30

    Applicant: EMD Millipore Corporation

    Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

    IPC: A61L2/00 ,  B01D19/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08

    Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.

    Method for improved scaling of filters
    9.
    发明授权
    Method for improved scaling of filters 有权
    改进滤波器缩放的方法

    公开(公告)号：US08904641B2

    公开(公告)日：2014-12-09

    申请号：US13754928

    申请日：2013-01-31

    Applicant: EMD Millipore Corporation

    Inventor： Sal Giglia ,  Kevin Rautio ,  Mark Blanchard

    IPC: B23P15/16 ,  B01D69/02 ,  B01D65/10 ,  G01N15/08

    CPC classification number: B01D69/02 ,  B01D65/10 ,  B01D2325/20 ,  G01N15/0826 ,  Y10T29/496 ,  Y10T29/49604 ,  Y10T29/4978

    Abstract: Method of reducing performance variability of membrane scaling devices. Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly.

    Abstract translation: 降低膜缩放装置的性能变异性的方法。 缩小设备性能不确定度，从而通过指定所有合格制造膜组的窄范围或子集来安装到缩放设备中，从而降低了比例安全系数。 在某些实施例中，通过确定特定膜所在的性能分布内的哪里以及相应地调整缩放因子来减小可伸缩性因子。

    Method For Improved Scaling Of Filters
    10.
    发明申请
    Method For Improved Scaling Of Filters 有权
    改进滤波器缩放方法

    公开(公告)号：US20130140224A1

    公开(公告)日：2013-06-06

    申请号：US13754928

    申请日：2013-01-31

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Sal Giglia ,  Kevin Rautio ,  Mark Blanchard

    IPC: B01D69/02

    CPC classification number: B01D69/02 ,  B01D65/10 ,  B01D2325/20 ,  G01N15/0826 ,  Y10T29/496 ,  Y10T29/49604 ,  Y10T29/4978

    Abstract: Method of reducing performance variability of membrane scaling devices. Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly.

    Abstract translation: 降低膜缩放装置的性能变异性的方法。 缩小设备性能不确定度，从而通过指定所有合格制造膜组的窄范围或子集来安装到缩放设备中，从而降低了安全系数。 在某些实施例中，通过确定特定膜所在的性能分布内的哪里以及相应地调整缩放因子来减小可伸缩性因子。

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