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公开(公告)号：US12201925B2
公开(公告)日：2025-01-21
申请号：US17682221
申请日：2022-02-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：USD1024760S1
公开(公告)日：2024-04-30
申请号：US29867785
申请日：2022-11-08
Applicant: EMD Millipore Corporation
Designer： James Ormond , Heejin Lee
Abstract: FIG. 1 is a first perspective view of the tubing clip of the present invention.
FIG. 2 is a second perspective view of the tubing clip of the present invention.
FIG. 3 is a front view of the tubing clip of the present invention.
FIG. 4 is a rear view of the tubing clip of the present invention.
FIG. 5 is a left-side view of the tubing clip of the present invention.
FIG. 6 is a right-side view of the tubing clip of the present invention.
FIG. 7 is a top view of the tubing clip of the present invention; and,
FIG. 8 is a bottom view of the tubing clip of the present invention.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting the orientation of the tubing clip.-
公开(公告)号：US20240050900A1
公开(公告)日：2024-02-15
申请号：US18493880
申请日：2023-10-25
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen
CPC classification number: B01D63/12 , C02F1/44 , C02F1/442 , C02F1/441 , B01D63/103 , B01D61/025 , B01D61/145 , B01D63/10 , D06C15/02 , C02F1/444 , B01D2313/14 , B01D71/68
Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.
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公开(公告)号：US20240001306A1
公开(公告)日：2024-01-04
申请号：US18254970
申请日：2021-12-16
Applicant: EMD Millipore Corporation
Inventor： Rebecca Rodenhiser , Salvatore Giglia , Christopher Johnson
CPC classification number: B01D65/102 , G01N15/0826 , G01N2015/084
Abstract: The disclosure herein relates to a method of reducing background noise during integrity testing of membrane filter to increase sensitivity and more effectively disposition failing membrane filters.
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公开(公告)号：US20230330574A1
公开(公告)日：2023-10-19
申请号：US18185015
申请日：2023-03-16
Applicant: EMD Millipore Corporation
Inventor： John Paul Amara , James Ormond , Kevin McDermot
IPC: B01D35/30
Abstract: The present invention is for a magnetized filter holder.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230324253A1
公开(公告)日：2023-10-12
申请号：US18297085
申请日：2023-04-07
Applicant: EMD Millipore Corporation
Inventor： Brian Pereira , Stephen Proulx
CPC classification number: G01M3/3218 , B01L3/505 , B01L2300/0861
Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
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公开(公告)号：US11679349B2
公开(公告)日：2023-06-20
申请号：US17315721
申请日：2021-05-10
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/145 , B01D61/146 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20230182058A1
公开(公告)日：2023-06-15
申请号：US18165543
申请日：2023-02-07
Applicant: EMD Millipore Corporation
Inventor： Joseph Geringer , Robert Castro , Martin Szyk , Sophie Daudenarde , Joseph Almasian
CPC classification number: B01D46/4272 , B01D46/0004
Abstract: Port protection device particularly suited for an encapsulated filter unit. In certain embodiments, the protection device comprises a main body defining an internal region configured to receive a port or the like protruding from an encapsulated filter. In certain embodiments, the main body includes a slot that allows for easy removal of the protection device from the port or the like. A tube management system may be provided to receive and hold tubing. One suitable tube management system includes two spaced tangs that extend from the main body of the protection device and are configured to cooperatively receive and hold tubing between them.
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公开(公告)号：US11660555B2
公开(公告)日：2023-05-30
申请号：US14890774
申请日：2014-09-02
Applicant: EMD Millipore Corporation
Inventor： Maybelle Woo , David Yavorksy , John Amara , Nripen Singh , Kwok-Shun Cheng
CPC classification number: B01D39/1623 , B01D29/66 , B01D39/163 , B01D2239/0407 , B01D2239/0654 , B01D2239/086
Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyaeryionitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased creased binding capacity for soluble impurities such as DNA and host eel! proteins from biological/cell culture feed-streams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
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公开(公告)号：US20230158429A1
公开(公告)日：2023-05-25
申请号：US18153078
申请日：2023-01-11
Applicant: EMD Millipore Corporation
Inventor： Maybelle Woo , David Yavorsky , John Amara , Nripen Singh , Kwok-Shun Cheng
CPC classification number: B01D39/1623 , B01D29/66 , B01D39/163 , B01D2239/086 , B01D2239/0407 , B01D2239/0654
Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
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