公开(公告)号：US20210354055A1

公开(公告)日：2021-11-18

申请号：US17312109

申请日：2020-03-26

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  John Paul Amara ,  Kara M. Pizzelli ,  Shannon Ryan

IPC: B01D24/10 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  G01N1/40 ,  G01N1/34

Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.

公开(公告)号：US12076666B2

公开(公告)日：2024-09-03

申请号：US17312109

申请日：2020-03-26

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  John Paul Amara ,  Kara M. Pizzelli ,  Shannon Ryan

IPC: B01D24/10 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  G01N1/34 ,  G01N1/40

CPC classification number: B01D24/10 ,  B01D39/1623 ,  B01D39/18 ,  B01D39/2068 ,  G01N1/34 ,  G01N1/4077 ,  B01D2201/182 ,  G01N2001/4088

Abstract: Depth filters with optimized head space are provided, as well as methods of optimizing the head space in depth filters, and methods of filtration with depth filters having optimized head space, including clarification of flocculated feed streams where pretreatment may include any of lowering cell culture pH, addition of polymers (uncharged or charged), or addition of salts to precipitate out solubilized impurities resulting in high insoluble biomass.