公开(公告)号：US12104179B2

公开(公告)日：2024-10-01

申请号：US18474786

申请日：2023-09-26

Applicant: EMPYREAN NEUROSCIENCE, INC.

Inventor： Thomas Henley ,  Modassir Choudhry ,  Jose Fernandez-Gomez ,  Antoine Larrieu ,  Beata Orman-Ligeza ,  Umar Mohammed ,  Emma McKechnie-Welsh

IPC: C12N9/10 ,  A61K35/66 ,  C12N9/22 ,  C12N15/11

CPC classification number: C12N9/1007 ,  A61K35/66 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20 ,  C12N2800/80

Abstract: This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.

公开(公告)号：US11905535B2

公开(公告)日：2024-02-20

申请号：US17812826

申请日：2022-07-15

Applicant: EMPYREAN NEUROSCIENCE, INC.

Inventor： Thomas Henley ,  Modassir Choudhry ,  Jose Fernandez-Gomez

IPC: C12N9/02 ,  A61K36/07 ,  C12N9/10 ,  C12N9/12 ,  C12N9/88

CPC classification number: C12N9/0083 ,  A61K36/07 ,  C12N9/1007 ,  C12N9/1205 ,  C12N9/88 ,  C12Y114/99 ,  C12Y201/01 ,  C12Y207/01 ,  C12Y401/01

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.