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公开(公告)号：US20210198183A1
公开(公告)日：2021-07-01
申请号：US17047123
申请日：2019-04-19
发明人： Ki Young SOHN , Jae Wha KIM , Sun Young YOON , Chang Hyun YOO , Jin Seon JEONG
IPC分类号： C07C233/20 , C07C233/18 , C07C233/38 , C07C327/28 , C07C235/06 , C07C69/708 , A61P37/06
摘要： Disclosed are a glycerol derivative that is useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4, IL-6 and so on, or chemokine CXCL8 and reducing migration of HL-60 cell lines, preparation method therefor, and an immunomodulator containing the same as active ingredient. It includes a glycerol derivative represented by Chemical formula 2 or 3 in the specification.
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公开(公告)号：US20210002197A1
公开(公告)日：2021-01-07
申请号：US16978873
申请日：2019-03-25
发明人： Ki Young SOHN , Jae Wha KIM , Sun Young YOON , Chang Hyun YOO , Jin Seon JEONG
摘要： Disclosed are a novel 1,2-diacylglycerol compound that useful for improving, preventing or treating inflammation-related diseases by inhibiting overexpression of various inflammatory cytokines such as IL-4 and IL-6 or chemokine CXCL8 related to the migration of inflammatory cells, a method for preparing the same, and an immunomodulator containing the same as an active ingredient. The 1,2-diacylglycerol compound is represented by Chemical Formula 2 in the patent specification.
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公开(公告)号：US20210002242A1
公开(公告)日：2021-01-07
申请号：US16977548
申请日：2019-03-08
发明人： Ki Young SOHN , Jae Wha KIM , Sun Young YOON , Chang Hyun YOO , Jin Seon JEONG
IPC分类号： C07D307/32 , A23L33/00 , A23L29/00 , A61P31/04
摘要： Disclosed are a novel diacylglycerol lactone compound for improving immunity and inhibiting infection by promoting neutrophil movement, a preparation method therefor, and an immunostimulator containing same as an active ingredient. The diacyloglycerol lactone compound is represented by chemical formula 1 of the specification. In chemical formula 1, R1 and R2 are respectively N and independently a C2-30 fatty acid group.
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