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1.发明授权公开(公告)号：US09238094B2
公开(公告)日：2016-01-19
申请号：US13842066
申请日：2013-03-15
Applicant: ETHICON, INC.
Inventor： Sasa Andjelic , Benjamin D. Fitz , Jianguo Jack Zhou
IPC: C08L67/04 , A61L31/06 , A61L27/18 , C08L69/00 , C08L101/16 , D01D5/098 , D01F6/62 , D01F6/68 , D01F6/86 , B29D7/00 , D04H1/56 , A61L27/58 , A61L31/14 , B29C71/00
CPC classification number: A61L31/06 , A61L27/18 , A61L27/58 , A61L31/148 , B29C71/00 , B29D7/00 , C08L67/04 , C08L69/00 , C08L101/16 , C08L2203/02 , C08L2205/02 , D01D5/0985 , D01F6/625 , D01F6/68 , D01F6/86 , D04H1/56 , Y10T442/609 , C08L2666/18
Abstract: A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.
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Patent Agency Ranking
2.发明申请In Vitro Methodology for Predicting in Vivo Absorption Time of Bioabsorbable Polymeric Implants and Devices 审中-公开用于预测生物可吸收聚合物植入物和器件的体内吸收时间的体外方法公开(公告)号：US20130330827A1
公开(公告)日：2013-12-12
申请号：US13682275
申请日：2012-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Benjamin D. Fitz , Dachuan Yang
IPC: G01N33/44
CPC classification number: G01N33/442 , A61F2210/0004 , A61L27/58
Abstract: A novel in vitro methodology for predicting the in vivo behavior, such as absorption time or mechanical strength retention, of biodegradable polymeric implants and medical devices. The present invention provides a novel in vitro methodology, hydrolysis profiling, for studying the degradation of absorbable polymers. Accuracy and reproducibility have been established for selected test conditions. Data from this in vitro method are correlated to in vivo absorption data, allowing for the prediction of accurate in vivo behaviors, such as absorption times.
Abstract translation: 用于预测可生物降解的聚合物植入物和医疗装置的体内行为（例如吸收时间或机械强度保留）的新型体外方法。 本发明提供了一种用于研究可吸收聚合物降解的新的体外方法学，水解分析。 已经为选定的试验条件建立了准确性和重复性。 来自该体外方法的数据与体内吸收数据相关，允许预测准确的体内行为，例如吸收时间。
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公开(公告)号：US20170172805A1
公开(公告)日：2017-06-22
申请号：US15450706
申请日：2017-03-06
Applicant: Ethicon, Inc.
Inventor： Benjamin D. Fitz , Dwayne Looney , Thomas Lee Craven , Clifford Dey , Atul Garg
CPC classification number: A61F13/00012 , A61F13/00987 , A61L15/28 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2400/04 , D04B1/14 , D04H1/4258 , D04H1/46 , Y10T442/51
Abstract: The present invention is directed to a resorbable hemostatic nonwoven felt suitable for use in laparoscopic procedures and to methods for manufacturing said felt.
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4.发明授权Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates 有权表现出增强的结晶和水解速率的生物可吸收聚合物组合物公开(公告)号：US09173980B2
公开(公告)日：2015-11-03
申请号：US13842265
申请日：2013-03-15
Applicant: ETHICON, INC.
Inventor： Sasa Andjelic , Benjamin D. Fitz
IPC: C08L67/04 , A61L31/06 , A61L27/18 , C08L69/00 , C08L101/16 , D01D5/098 , D01F6/62 , D01F6/68 , D01F6/86 , B29D7/00 , D04H1/56 , A61L27/58 , A61L31/14 , B29C71/00
CPC classification number: A61L31/06 , A61L27/18 , A61L27/58 , A61L31/148 , B29C71/00 , B29D7/00 , C08L67/04 , C08L69/00 , C08L101/16 , C08L2203/02 , C08L2205/02 , D01D5/0985 , D01F6/625 , D01F6/68 , D01F6/86 , D04H1/56 , Y10T442/609 , C08L2666/18
Abstract: A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50/50 to about 95/5 weight/weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.
Abstract translation: 双峰生物可吸收聚合物组合物。 所述组合物包含第一量聚合以具有第一分子量分布的生物可吸收聚合物; 所述第二量的所述生物可吸收聚合物被聚合以具有重均分子量在约10,000至约50,000道尔顿之间的第二分子量分布，所述第一分子量分布与所述第二分子量分布的重均分子量比为 至少约二比一; 其中所述第一和第二量的所述生物可吸收聚合物的基本均匀的共混物以约50/50至约95/5重量/重量％的比例形成。 还公开了医疗装置，制造医疗装置的方法和熔融吹制半结晶聚合物共混物的方法。
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公开(公告)号：US20220331475A1
公开(公告)日：2022-10-20
申请号：US17667787
申请日：2022-02-09
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Thomas Weindl , Benjamin D. Fitz , Gerard Llanos , Guanghui Zhang , Yi-Lan Wang , Meng Deng
Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
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公开(公告)号：US10111782B2
公开(公告)日：2018-10-30
申请号：US15450706
申请日：2017-03-06
Applicant: Ethicon, Inc.
Inventor： Benjamin D. Fitz , Dwayne Looney , Thomas Lee Craven , Clifford Dey , Atul Garg
Abstract: The present invention is directed to a resorbable hemostatic nonwoven felt suitable for use in laparoscopic procedures and to methods for manufacturing said felt.
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