公开(公告)号：US20240207403A1

公开(公告)日：2024-06-27

申请号：US18557792

申请日：2022-04-29

申请人： Evolve Biosystems, Inc.

发明人： Bethany HENRICK ,  Petter BRODIN

IPC分类号： A61K39/00 ,  A61K31/19 ,  A61K31/405 ,  A61K35/24 ,  A61K35/745 ,  A61K35/747 ,  A61K38/18 ,  A61K38/20 ,  A61K38/21 ,  A61P37/06 ,  C12N1/20 ,  C12N5/0783

CPC分类号： A61K39/4621 ,  A61K31/19 ,  A61K31/405 ,  A61K35/24 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1841 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2066 ,  A61K38/215 ,  A61K38/217 ,  A61K39/4611 ,  A61P37/06 ,  C12N1/20 ,  C12N5/0636

摘要： Disclosed is a T cell polarizing composition comprising a plurality of metabolites selected from metabolites enriched in non-dysbiotic feces, preferably including one or more of acetate, lactate, indole 3 lactate, 3-(4-hydroxyphenyl)lactate, or phenyllactate, bile acids (cholate, chenodeoxycholate, cholate sulfate), or IFNbeta. Further disclosed is a method of producing the T cell polarizing composition comprising mixing interferon beta (IFNbeta), acetate, lactate, and/or ILA.

公开(公告)号：US20220248738A1

公开(公告)日：2022-08-11

申请号：US17630018

申请日：2020-07-27

申请人： Evolve BioSystems, Inc.

发明人： David KYLE ,  Samara FREEMAN-SHARKEY ,  Bethany HENRICK

IPC分类号： A23L33/19 ,  A23L33/115 ,  A23L33/135 ,  A23L33/21 ,  A23L33/00

摘要： This disclosure describes compositions of one or more components including milk fat globule membranes (MFGM) complexes, milk fat globules (MFG), commensal organisms, SlgA, recombinant SlgA (rSlgA), triglycerides or oils, and mammalian milk oligosaccharides (MMO) and the use of such compositions. The reconstituted MFGM component of the disclosed invention may come from an animal source, particularly from a mammalian source, including from the processing of buttermilk.

公开(公告)号：US20210069268A1

公开(公告)日：2021-03-11

申请号：US16646687

申请日：2018-09-13

申请人： EVOLVE BIOSYSTEMS, INC.

发明人： Bethany HENRICK ,  Steven FRESE ,  David KYLE ,  Samara FREEMAN-SHARKEY ,  Giorgio CASABURI

IPC分类号： A61K35/747 ,  A61K31/198 ,  A61K35/20 ,  A61K35/745 ,  A61K35/744 ,  A61P1/14

摘要： The inventions described herein relate generally to the use of compositions to increase output of particular metabolites in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.

公开(公告)号：US20220313759A1

公开(公告)日：2022-10-06

申请号：US17655825

申请日：2022-03-22

申请人： Evolve BioSystems, Inc.

发明人： David KYLE ,  Steven FRESE ,  Samara FREEMAN-SHARKEY ,  Bethany HENRICK

IPC分类号： A61K35/747 ,  A61K31/702 ,  A61K35/745 ,  A23L33/135 ,  A23K10/18 ,  A61K35/741 ,  A23L33/00 ,  A61K35/744 ,  C12Q1/689

摘要： The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.

公开(公告)号：US20210308196A1

公开(公告)日：2021-10-07

申请号：US15733936

申请日：2019-06-03

申请人： EVOLVE BIOSYSTEMS, INC.

发明人： Steven A. FRESE ,  Bethany HENRICK

IPC分类号： A61K35/745 ,  A61K31/07 ,  A61K31/198 ,  A61K31/702 ,  A61K47/26 ,  A61K35/20 ,  A61K9/00 ,  A61P37/04 ,  A61P11/06 ,  A61P1/14 ,  A61P37/08 ,  A61K31/05 ,  A23L33/155 ,  A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A23L33/175 ,  A23K20/174 ,  A23K20/163 ,  A23K10/18 ,  A23K20/142

摘要： Compositions comprising vitamin A, vitamin D, threonine, mammalian milk oligosaccharides, and Bifidobacterium, B. infantis cell wall components and their uses to treat or prevent diseases, support therapies including metabolic and autoimmune diseases.

公开(公告)号：US20190224254A1

公开(公告)日：2019-07-25

申请号：US16314580

申请日：2017-06-30

申请人： EVOLVE BIOSYSTEMS, INC.

发明人： David KYLE ,  Steven FRESE ,  Samara FREEMAN-SHARKEY ,  Bethany HENRICK

IPC分类号： A61K35/747 ,  A23L33/135 ,  A23L33/00 ,  A23K10/18 ,  C12Q1/689 ,  A61K31/702 ,  A61K35/745 ,  A61K35/744

摘要： The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.