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公开(公告)号：US20200237836A1
公开(公告)日：2020-07-30
申请号：US16676163
申请日：2019-11-06
IPC分类号： A61K35/744 , A61K31/7012 , A61K35/745 , A61K35/747 , A23L33/00 , A23K10/18 , A61K35/74 , A23K50/20 , A61K31/7004 , A61K9/16 , A23L33/125 , A23L33/135 , A23K50/60 , A23K50/30 , A61K9/19 , A23L33/21
摘要： Compositions comprising at least two non-pathogenic microbes are described herein. The non-pathogenic microbes may be from a first species capable of internalizing and/or metabolizing dietary glycans and/or from a second species capable of consuming and metabolizing free sugar monomers. Methods of making and use in treating and/or preventing the overgrowth of pathogenic bacteria in mammals are also described herein.
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公开(公告)号：US20220313759A1
公开(公告)日：2022-10-06
申请号：US17655825
申请日：2022-03-22
IPC分类号： A61K35/747 , A61K31/702 , A61K35/745 , A23L33/135 , A23K10/18 , A61K35/741 , A23L33/00 , A61K35/744 , C12Q1/689
摘要： The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.
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公开(公告)号：US20190224254A1
公开(公告)日：2019-07-25
申请号：US16314580
申请日：2017-06-30
IPC分类号： A61K35/747 , A23L33/135 , A23L33/00 , A23K10/18 , C12Q1/689 , A61K31/702 , A61K35/745 , A61K35/744
摘要： The inventions described herein relate generally to the use of compositions to increase output of acetate and lactate while reducing pH and the levels of pathogenic bacteria and inflammation in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.
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公开(公告)号：US20220248738A1
公开(公告)日：2022-08-11
申请号：US17630018
申请日：2020-07-27
IPC分类号： A23L33/19 , A23L33/115 , A23L33/135 , A23L33/21 , A23L33/00
摘要： This disclosure describes compositions of one or more components including milk fat globule membranes (MFGM) complexes, milk fat globules (MFG), commensal organisms, SlgA, recombinant SlgA (rSlgA), triglycerides or oils, and mammalian milk oligosaccharides (MMO) and the use of such compositions. The reconstituted MFGM component of the disclosed invention may come from an animal source, particularly from a mammalian source, including from the processing of buttermilk.
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公开(公告)号：US20210069268A1
公开(公告)日：2021-03-11
申请号：US16646687
申请日：2018-09-13
IPC分类号： A61K35/747 , A61K31/198 , A61K35/20 , A61K35/745 , A61K35/744 , A61P1/14
摘要： The inventions described herein relate generally to the use of compositions to increase output of particular metabolites in the gut of a nursing infant mammal including humans. These compositions generally comprise one or more bacterial strains selected for their growth on mammalian milk oligosaccharides, a source of mammalian milk oligosaccharides, and, optionally, nutritive components required for the growth of that infant mammal.
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公开(公告)号：US20180267037A1
公开(公告)日：2018-09-20
申请号：US15539172
申请日：2015-12-23
发明人： David KYLE , David MILLS , Carlito LEBRILLA
IPC分类号： G01N33/569 , G01N33/558 , C07K16/12
CPC分类号： G01N33/56911 , C07K16/1292 , G01N33/558 , G01N33/582 , G01N33/60 , G01N2333/36 , G01N2469/20
摘要： Some embodiments of the invention include a kit and a device for detecting activated bifidobacteria. Methods of making and using the kit and/or device are also described herein.
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公开(公告)号：US20220273733A1
公开(公告)日：2022-09-01
申请号：US17629865
申请日：2020-07-27
IPC分类号： A61K35/745 , A61K31/716 , A61K31/702 , A61K38/48 , A61K45/06 , A61P1/14 , A61P31/04
摘要： The inventions described herein relate generally to compositions comprising bioactive proteins including, but not limited to, enzymes and antimicrobial proteins. Such bioactive protein compositions may be present alone or in a mammalian milk or soy-based nutritional product to increase colonization of desired commensal organisms, reduce potential pathogens, restore microbiome function, and/or otherwise improve health in a mammal consuming same.
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8.发明申请公开(公告)号：US20200245667A1
公开(公告)日：2020-08-06
申请号：US16646628
申请日：2018-09-13
IPC分类号： A23L33/125 , A23K10/14 , A23K10/30 , A23K20/163 , A23K10/18 , A23K50/20 , A23K50/30 , A23K50/60 , A23L33/00 , A23L33/21 , A23L33/135
摘要： This invention provides compositions of oligosaccharides, their preparation, and their use to facilitate the growth of certain beneficial gut bacteria over other gut bacteria in a mammal in order to prevent gastrointestinal distress associated with a major change in gut microflora, such as that which occurs when an infant is weaned from its mother's milk to alternative food sources, or during the recovery of the gut microbiome after a course of oral antibiotics, hospitalization, therapy such as chemotherapy or radiation treatments, or conditions where a deficiency in dietary fiber is observed. Novel compositions of oligosaccharides, oligosaccharides and bacteria, foods comprising those compositions, and methods of preparation and use of those compositions are described.
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公开(公告)号：US20190069586A1
公开(公告)日：2019-03-07
申请号：US16084207
申请日：2017-03-13
发明人： David KYLE , Samara FREEMAN-SHARKEY , Steven FRESE
IPC分类号： A23L33/135 , A61K35/745 , A61K35/747 , A23L33/00 , A23L33/21 , A23K50/30 , A23K10/18 , A23K20/163 , A23K50/60 , A23L11/00 , A23L19/10
摘要： The inventions described herein relate generally to digestive healthcare, and more particularly, to the feeding of mammals, particularly human infants, who are making a transition from a microbiome with lower diversity to a microbiome with higher diversity. These inventions relate to certain foods comprising a fermentable nutritional component and a probiotic component, where the probiotic component is selected, based on genetic and/or metabolic criteria, to specifically metabolize any Free Sugar Monomers (FSMs) and Free Amino Acids (FAAs) or peptides that accumulate as a result of the fermentable nutritional component in the lower intestine, where they otherwise might be left in the environment to be fermented and metabolized by less adapted/opportunistic bacteria, creating blooms of deleterious intestinal bacteria and shifting the microbiome to a potentially dysbiotic state. The present inventions provide combinations of foods and probiotic bacteria that can protect the mammalian gut from blooms of pathogenic bacteria under the circumstances where the mammalian gut is starting out with a low microbial diversity, such as in weaning infants, or individuals who are post-antibiotic treatment and/or post-chemotherapeutic treatment and transitioning to a higher diversity adapted/stable microbiome.
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10.发明申请公开(公告)号：US20180104157A1
公开(公告)日：2018-04-19
申请号：US15567250
申请日：2016-04-15
发明人： David KYLE , David MILLS , Samara FREEMAN-SHARKEY
IPC分类号： A61J15/00 , A61K35/745 , A61K35/747
CPC分类号： A61J15/0003 , A23G1/50 , A23G1/56 , A23L33/135 , A23L33/40 , A61J15/00 , A61J15/0011 , A61J15/0015 , A61K35/745 , A61K35/747
摘要： Devices and methods for delivering non-pathogenic, intestinally beneficial bacteria to a patient having a feeding tube. Examples of non-pathogenic, intestinally beneficial bacteria that could be used include Bifidobacterium species and Lactobacillus species. In one embodiment, the bacteria is contained in a bacteria infusion device that comprises: (a) an internal chamber; (b) an outlet in communication with the internal chamber; and (c) the non-pathogenic, intestinally beneficial bacteria contained in the internal chamber. Another embodiment is a feeding tube comprising a flexible tubing and coating on the outer surface of the flexible tubing. The coating comprises an antimicrobial agent. Also disclosed are methods of administering a non-pathogenic, intestinally beneficial bacteria to a patient.
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