公开(公告)号：US11766665B2

公开(公告)日：2023-09-26

申请号：US17563421

申请日：2021-12-28

Applicant: East China University of Science and Technology

Inventor： Yanqin Wang ,  Wanjun Guo ,  Shuang Xiang ,  Xiaohui Liu ,  Yong Guo

IPC: C07C209/78 ,  B01J23/75 ,  B01J23/78 ,  B01J23/83 ,  B01J23/882 ,  B01J35/00 ,  B01J37/03 ,  B01J37/08 ,  B01J37/18

CPC classification number: B01J23/75 ,  B01J23/78 ,  B01J23/83 ,  B01J23/882 ,  B01J35/0006 ,  B01J37/031 ,  B01J37/082 ,  B01J37/18 ,  C07C209/78 ,  C07C2601/08

Abstract: Disclosed is a method for efficiently synthesizing primary amines, which comprises using carbonyl compounds or alcohol compounds as reaction substrate, liquid ammonia or alcohol solutions of ammonia as nitrogen source, and hydrogen as hydrogen source, and reacting in reaction medium catalyzed by a cobalt-based catalyst to obtain the primary amines. Due to high catalytic activity, the method can realize the reductive amination of carbonyl compounds and the hydrogen-borrowing amination of alcohol compounds at low temperatures in a short time to obtain the primary amines with high yield, and is applicable to a wide range of substrates. The obtained primary amines can be used as raw materials with high extra value for producing polymers, medicines, dyes and surfactants. Further, the cobalt-based catalyst has a good industrial application prospect because it is magnetic which can facilitate separation and recycling of the catalyst. Moreover, the inexpensive cobalt-based catalyst can significantly reduce industrialization cost.