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15 条记录 (耗时 0.016 秒)

    Drive shield
    6.
    发明授权
    Drive shield 失效
    驱动盾

    公开(公告)号：US4143519A

    公开(公告)日：1979-03-13

    申请号：US875726

    申请日：1978-02-07

    申请人： Eberhard Unger

    发明人： Eberhard Unger

    IPC分类号： E21D9/06 ,  E21D19/00

    CPC分类号： E21D9/0692 ,  E21D9/0607

    摘要： A drive shield for driving wide underground cavities comprises a plurality of knife shields arranged side-by-side transversely of the direction of advance. Each knife shield has a plurality of elongate knives displaceably mounted on a respective support frame. The elongate knives are advanceable relative to their support frame by means of hydraulic rams mounted on that support frame. The support frames of each pair of adjacent knife shields are linked by connecting means such as double-acting hydraulic rams, which permit one of the support frames to be advanced relative to the other.

    摘要翻译： 用于驱动宽的地下空腔的驱动器屏蔽包括横向于前进方向并排布置的多个刀屏蔽件。 每个刀罩具有可移动地安装在相应的支撑框架上的多个细长刀。 通过安装在该支撑框架上的液压柱塞，细长刀相对于其支撑框架可前进。 每对相邻刀片护罩的支撑框架通过诸如双作用液压柱塞的连接装置连接，这允许一个支撑框架相对于另一个前进。

    Apparatus for and method of driving tunnels
    7.
    发明授权
    Apparatus for and method of driving tunnels 失效
    隧道驱动装置及其运行方法

    公开(公告)号：US4118938A

    公开(公告)日：1978-10-10

    申请号：US738419

    申请日：1976-11-03

    申请人： Eberhard Unger ,  Wolf-Rudiger Von Schenk

    发明人： Eberhard Unger ,  Wolf-Rudiger Von Schenk

    IPC分类号： E21D9/06 ,  E21D11/10

    CPC分类号： E21D9/0607

    摘要： Apparatus for use in tunnel driving employs a drive shield of known type with elongate drive members arranged side-by-side and supported and guided by a rigid frame. Hydraulic rams are used to alternately advance individual members or groups of members and the frame. Fluid concrete is introduced behind the shield to form a permanent lining supported by formwork and sealed to the tunnel wall by sheet material. The fluid concrete is contacted during its setting period by a hollow ring member of the formwork. The ring member is provided with a filter structure permitting water to be withdrawn by suction. Further separate hydraulic rams interconnect the ring member and the frame of the drive shield enabling the fluid concrete to be compressed. Some of the drive members have prolonged thin rear extensions which form tails extending partly around the concreting zone in contact with the tunnel wall. Pipes are provided to introduce further concrete or other filling material into the gaps created when these tails are shifted up.

    摘要翻译： 用于隧道行驶的装置采用已知类型的驱动罩，其细长的驱动构件并排布置并由刚性框架支撑和引导。 液压柱塞用于交替地推进各个构件或构件的构件和框架。 流体混凝土被引入盾构后面，形成一个由模板支撑的永久性衬里，并通过板材密封到隧道壁。 流体混凝土在其设置期间通过模板的中空环构件接触。 环形构件设置有允许通过抽吸抽出水的过滤器结构。 进一步的单独的液压柱塞将环形构件和驱动罩的框架相互连接，使得能够压缩流体混凝土。 一些驱动构件具有延长的薄的后延伸部，其形成部分地围绕与隧道壁接触的混凝土区域延伸的尾部。 提供管道以将更多的混凝土或其他填充材料引入到当这些尾部向上移动时产生的间隙中。

    Antitumor-active 2-alkoxyestradiol sulfamates
    8.
    发明授权
    Antitumor-active 2-alkoxyestradiol sulfamates 失效
    抗肿瘤活性2-烷氧基雌二醇亚磺酸盐

    公开(公告)号：US08026229B2

    公开(公告)日：2011-09-27

    申请号：US10217165

    申请日：2002-08-13

    申请人： Ina Scherlitz-Hofmann ,  Jens Hoffmann ,  Alexander Hillisch ,  Eberhard Unger ,  Tobias Neumann ,  Sigfrid Schwarz ,  Olaf Peters ,  Thomas Michel

    发明人： Ina Scherlitz-Hofmann ,  Jens Hoffmann ,  Alexander Hillisch ,  Eberhard Unger ,  Tobias Neumann ,  Sigfrid Schwarz ,  Olaf Peters ,  Thomas Michel

    IPC分类号： A61K31/56 ,  C07J1/00

    CPC分类号： A61K31/565 ,  A61K31/56

    摘要： The present invention relates to the use of 2-alkoxyestrogen sulfamates of general formula I wherein R1 and R2 independently represent H, methyl, C1-C4 acyl, benzoyl R3 represents C1-C4 alkyl or a group of formula CnFmHo, wherein n=1, 2, 3, 4, 5 or 6, m>1, and m+o=2n+1, R4 and R5 in each case represent H or, together, a methylene group or an additional double bond, R6 represents H, R7 represents OH, OC1-C4-alkyl, OC1-C11-acyl or OSO2NR1R2, the dashed lines in the B and C rings of the steroid skeleton additionally representing up to two double bonds, for the production of a medical drug for the treatment of tumor diseases which can be affected positively by inhibiting the tubulin polymerization. The inventive compounds are distinguished by the 2-alkoxy substitution in conjunction with the 17-hydroxy substitution. They have a special effect with regard to inhibiting tubulin polymerization and can be used, for example, for the treatment of prostate cancers.

    摘要翻译： 本发明涉及通式Ⅰ的2-烷氧基雌激素亚磺酸盐的用途，其中R 1和R 2独立地表示H，甲基，C 1 -C 4酰基，苯甲酰基，R 3表示C 1 -C 4烷基或式C n F m H 0基团，其中n = 2，3，4，5或6，m≥1，m + o = 2n + 1，R4和R5各自表示H或一起为亚甲基或另外的双键，R6表示H，R7表示 OH，OC1-C4-烷基，OC1-C11-酰基或OSO2NR1R2，类固醇骨架的B和C环中的虚线另外代表多达两个双键，用于生产用于治疗肿瘤疾病的药物 这可以通过抑制微管蛋白聚合而受到积极的影响。 本发明化合物通过2-烷氧基取代与17-羟基取代相结合来区分。 它们在抑制微管蛋白聚合方面具有特殊的效果，并且可以用于例如前列腺癌的治疗。