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1.发明授权Topoisomerase I selective cytotoxic sugar derivatives of indolopyrrolocarbazoles 有权拓扑异构酶I吲哚吡咯并唑的选择性细胞毒性糖衍生物公开(公告)号：US06855698B2
公开(公告)日：2005-02-15
申请号：US10103908
申请日：2002-03-22
申请人： Edward H. Ruediger , Mark G. Saulnier , Francis Beaulieu , Carol Bachand , Neelakantan Balusubramanian , Byron Hepler Long , David B. Frennesson , Kurt Zimmermann , B. Narasimhulu Naidu , Karen Stoffan , Denis Robert St. Laurent
发明人： Edward H. Ruediger , Mark G. Saulnier , Francis Beaulieu , Carol Bachand , Neelakantan Balusubramanian , Byron Hepler Long , David B. Frennesson , Kurt Zimmermann , B. Narasimhulu Naidu , Karen Stoffan , Denis Robert St. Laurent
IPC分类号： C12P19/28 , A61K31/7052 , A61P35/00 , A61P43/00 , C07H15/00 , C07H19/00 , C07H19/23 , C12N1/12 , C12P17/10 , C12P17/18 , A01N43/04 , A61K31/70
摘要： The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
摘要翻译： 本发明涉及氟糖和其它表现出选择性拓扑异构酶I（拓扑I）活性的吲哚吡咯并唑的其衍生物及其盐和水合物，可用于抑制肿瘤细胞的增殖并具有抗肿瘤作用， 他们的准备。
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公开(公告)号：US06677450B2
公开(公告)日：2004-01-13
申请号：US09965976
申请日：2001-09-27
申请人： Mark G. Saulnier , Edward H. Ruediger , Neelakantan Balasubramanian , Mikael Mahler , Francis Beaulieu , Carol Bachand , David B. Frennesson
发明人： Mark G. Saulnier , Edward H. Ruediger , Neelakantan Balasubramanian , Mikael Mahler , Francis Beaulieu , Carol Bachand , David B. Frennesson
IPC分类号： C07H906
摘要： The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor cells.
摘要翻译： 本发明涉及展示拓扑异构酶-I活性并可用于抑制肿瘤细胞增殖的新型N12，N13桥连糖衍生物和吲哚吡咯并吡唑的药用制剂。
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公开(公告)号：US20120302747A1
公开(公告)日：2012-11-29
申请号：US13568750
申请日：2012-08-07
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： C07D487/04 , C07D491/08
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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公开(公告)号：US20080009497A1
公开(公告)日：2008-01-10
申请号：US11773466
申请日：2007-07-05
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： A61K31/53 , A61P35/00 , C07D403/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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公开(公告)号：US08592579B2
公开(公告)日：2013-11-26
申请号：US13568750
申请日：2012-08-07
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： C07D487/04 , C07D401/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
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公开(公告)号：US20110124623A1
公开(公告)日：2011-05-26
申请号：US13015687
申请日：2011-01-28
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： A61K31/397 , A61K31/53 , C07D487/04 , A61K31/5386 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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公开(公告)号：US07534792B2
公开(公告)日：2009-05-19
申请号：US11773466
申请日：2007-07-05
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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公开(公告)号：US07223757B2
公开(公告)日：2007-05-29
申请号：US11289834
申请日：2005-11-30
申请人： Mark D. Wittman , Neelakantan Balasubramanian , Upender Velaparthi , Kurt Zimmermann , Mark G. Saulnier , Peiying Liu , Xiaopeng Sang , David B. Frennesson , Karen M. Stoffan , James G. Tarrant , Anne Marinier , Stephan Roy
发明人： Mark D. Wittman , Neelakantan Balasubramanian , Upender Velaparthi , Kurt Zimmermann , Mark G. Saulnier , Peiying Liu , Xiaopeng Sang , David B. Frennesson , Karen M. Stoffan , James G. Tarrant , Anne Marinier , Stephan Roy
IPC分类号： C07D401/14 , C07D413/14 , A61K31/496 , A61K31/5377
CPC分类号： C07D417/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶，从而使其成为抗癌剂。 式I化合物还可用于治疗可通过抑制酪氨酸激酶的治疗的其它疾病。
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公开(公告)号：US07879855B2
公开(公告)日：2011-02-01
申请号：US12411724
申请日：2009-03-26
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： A61K31/53 , A61P35/00 , C07D487/04 , C07D401/14 , A61P19/02
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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公开(公告)号：US20090239838A1
公开(公告)日：2009-09-24
申请号：US12411724
申请日：2009-03-26
申请人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
发明人： Mark D. Wittman , Harold Mastalerz , Kurt Zimmermann , Mark G. Saulnier , Upender Velaparthi , Dolatrai M. Vyas , Guifen Zhang , Walter Lewis Johnson , David B. Frennesson , Xiaopeng Sang , Peiying Liu , David R. Langley
IPC分类号： A61K31/53 , A61P35/00 , A61K31/5377
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制酪氨酸激酶活性，从而使它们用作抗癌剂和治疗阿尔茨海默氏病。
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