Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
Abstract:
A machine housing having one wall with an outer side provided with ribs for the discharge of heat to the surrounding air. The ribs define undulation crests and there are curved undulation bases between the undulation crests. The ratio between the wall thickness and the rib height and the ratio between the rib pitch or spacing of the wall thickness and the radius of curvature of the undulations as compared with the wall thickness are all recited. The ribs preferably are parallel and preferably extend vertically in the installed position of the machine housing.
Abstract:
The present invention relates to a new isolated polypeptide nominated microcin S, isolated nucleic acid molecules encoding the microcin S polypeptide and primers and probes hybridizing to the nucleic acid molecules. The invention also relates to plasmids and cells comprising the nucleic acid molecules, an antibody binding to the polypeptide, compositions as well as methods for producing and using the polypeptides. The present invention further relates to medical uses for treating or preventing microbial infections, functional gastrointestinal disorders or treating a tumor. The invention further relates to a method for preserving food and a method for coating dressing material.
Abstract:
The invention provides compounds of formula I and pharmaceutically acceptable salts thereof.The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
Abstract:
The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
Abstract:
In a method for ascertaining phyto-specific characteristics for differently grown crops to differentiate between crop plants that have been subjected to different methods of growing, the following plant parametersFG.sub.max =maximum fresh weight,TG=dry weightAcP=proportion by weight of cell components capable of swellingAH.sub.2 O=proportion by weight of adsorptive waterWH.sub.2 O=proportion of cell water by weightare ascertained and are related to each other in the form of a ratio relativizing locality-dependent modifications. In accordance with a second form of the invention an enzyme, such as glutamate dehydrogenase, or an enzyme mixture present in the plants to be investigated and reacting particularly sensitively to an alteration in the supply of nitrogen, is isolated and the relaxation time .tau. of the enzyme is ascertained for different enzyme concentrations.
Abstract:
An electric machine, particularly for starting devices, is suggested. Permanent magnets (4 to 9) with assigned flux conducting pieces (10 to 15) are arranged in the housing (1) of the electric machine. The permanent magnets (4 to 9), together with the flux conducting pieces (10 to 15), are preassembled in two rings (18, 19) as retaining parts to form a constructional unit. Each ring (18, 19) has a cylindrical portion (20; 30) which contacts the end portions of the inner side (21; 22) of the permanent magnets (4 to 9) or the flux conducting pieces (10 to 15). A flangelike edge (25; 33) of the rings (18; 19) contacts the front sides (23, 24; 31, 32) of the permanent magnets (4 to 9) and the flux conducting pieces (10 to 15). Tabs (26, 27; 34, 35), which contact the end portions of the free longitudinal sides (17; 28 ) of the permanent magnets (4 to 9) or the flux conducting pieces (10 to 15), are bent out from the edges 25 and 33. A ring (19) is provided with fastening means (36 to 41) for the detachable fastening of the magnet group (4 to 15, 18, 19) at projections (3) of the housing (1).
Abstract:
The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof The Formula (I) compounds inhibit tyrosine kinase activity of Jak2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.