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公开(公告)号：US08415459B2
公开(公告)日：2013-04-09
申请号：US12262712
申请日：2008-10-31
申请人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
发明人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
CPC分类号： C07K16/22 , A61K39/395 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是抗GDF8抗体或抗原结合蛋白或其片段，其可抑制GDF8活性和信号 体外和/或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢退行性的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。
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公开(公告)号：US20090148436A1
公开(公告)日：2009-06-11
申请号：US12262712
申请日：2008-10-31
申请人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
发明人： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N5/10 , A61P21/00 , A61P19/08 , A61P3/00 , A61P25/00 , C12N15/63 , C12P21/00 , G01N33/53
CPC分类号： C07K16/22 , A61K39/395 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译： 本公开提供了与生长和分化因子-8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是抗GDF8抗体或抗原结合蛋白或其片段，其可抑制GDF8活性和信号 体外和/或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢退行性的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。
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公开(公告)号：US20100129360A1
公开(公告)日：2010-05-27
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395 , C07K16/24 , C07K16/18 , C07H21/00 , C12N5/10 , C12P21/00 , G01N33/543 , A61P37/02
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
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公开(公告)号：US08221752B2
公开(公告)日：2012-07-17
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白介素13（IL-13），特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
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