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公开(公告)号:US06555389B1
公开(公告)日:2003-04-29
申请号:US09470677
申请日:1999-12-23
申请人: Edwin F. Ullman , Sharat Singh , Ian Gibbons , Travis Boone , Torlief Bjornson
发明人: Edwin F. Ullman , Sharat Singh , Ian Gibbons , Travis Boone , Torlief Bjornson
IPC分类号: G01N33558
CPC分类号: B01L3/5027 , B01F13/0059 , B01J19/16 , B01J2219/00317 , B01L3/5025 , B01L3/502723 , B01L2200/0642 , B01L2200/142 , B01L2300/0861 , B01L2400/0406 , B01L2400/0415 , B01L2400/0688 , C40B60/14 , G01N1/34 , G01N2035/00237 , G01N2035/00287
摘要: Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a sample is placed in the zone where evaporation can occur. The zone is maintained in contact with a liquid medium that serves to replenish the liquid in the zone and maintain the composition of the mixture in the zone substantially constant. The diffusion of components in the zone is restricted during the course of the determination by the liquid flux into the zone.