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1.发明授权
公开(公告)号：US4130648A
公开(公告)日：1978-12-19
申请号：US860319
申请日：1977-12-14
IPC分类号： C07D239/545 , A61K31/505 , A61K31/506 , A61K31/513 , A61P35/00 , C07D311/04 , C07D405/12 , C07D239/54
CPC分类号： C07D405/12 , A61K31/505
摘要： Novel 5-fluorouracil derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen atom or methyl group, and R.sub.4 represents a straight or branched alkyl or alkenyl group, which has low toxicity and improved antitumor activity, and novel antitumor preparations containing the said 5-fluorouracil derivative.
摘要翻译： 新颖的5-氟尿嘧啶衍生物，其通式如下：其中R1，R2和R3各自表示氢原子或甲基，R4表示直链或支链烷基或烯基，具有低毒性和改善的抗肿瘤活性， 含有所述5-氟尿嘧啶衍生物的抗肿瘤制剂。
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公开(公告)号：US4459287A
公开(公告)日：1984-07-10
申请号：US389456
申请日：1982-06-17
IPC分类号： A61K36/47 , A61K38/16 , A61K38/36 , A61K39/39 , A61P31/04 , A61P35/00 , A61P37/04 , A61K37/00 , A61K39/00
CPC分类号： A61K39/39 , A61K38/168 , A61K2039/55516 , Y10S514/885
摘要： An immunopotentiator comprising ricin as an active ingredient. Ricin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections and cancer.
摘要翻译： 一种包含蓖麻毒蛋白作为活性成分的免疫增强剂。 蓖麻毒素是分子量约65,000的糖蛋白，可以以水溶液的形式使用。 它可用于预防和治疗细菌和病毒感染和癌症。
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公开(公告)号：US4414201A
公开(公告)日：1983-11-08
申请号：US384324
申请日：1982-06-01
IPC分类号： A61K36/48 , A61K38/16 , A61K38/36 , A61K39/39 , A61P31/04 , A61P35/00 , A61P37/04 , A61K37/00 , A61K39/00
CPC分类号： A61K38/168 , A61K39/39 , A61K2039/55516
摘要： An immunopotentiator comprising abrin as an active ingredient. Abrin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections.
摘要翻译： 一种包含相思豆毒素作为活性成分的免疫增强剂。 阿布林蛋白是分子量约65,000的糖蛋白，可以以水溶液的形式使用。 它可用于预防和治疗细菌和病毒感染。
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4.发明授权Pyranochromone derivatives and therapeutic composition comprising same for treatment of allergic diseases 失效苯并色酮衍生物和包含其的治疗组合物用于治疗过敏性疾病
公开(公告)号：US4208426A
公开(公告)日：1980-06-17
申请号：US927044
申请日：1978-07-24
IPC分类号： A61K31/35 , A61K31/365 , A61P37/08 , C07C45/46 , C07C49/825 , C07D311/24 , C07D311/58 , C07D311/64 , C07D493/04 , C07D311/78
CPC分类号： C07D493/04 , C07C45/46 , C07C49/825 , C07D311/24 , C07D311/58 , C07D311/64
摘要： Novel pyranochromone derivatives having the general formula: ##STR1## wherein R.sub.1 represents hydrogen atom, an alkali metal or an alkyl group containing 1-4 carbon atoms; R.sub.2, R.sub.3 and R.sub.4 represent hydrogen atom or an alkyl group containing 1-4 carbon atoms respectively, provided that both R.sub.3 and R.sub.4 are not hydrogen atom at the same time; R.sub.5 and R.sub.6 represent an alkyl group containing 1-4 carbon atoms respectively; and R.sub.7 represents hydrogen atom, hydroxyl group, an alkyl group containing 1-4 carbon atoms or an alkoxyl group containing 1-4 carbon atoms. The novel medicaments comprising predominantly the above derivative are effective for the treatment of allergic diseases.
摘要翻译： 具有以下通式的新型吡喃色酮衍生物：其中R 1表示氢原子，碱金属或含有1-4个碳原子的烷基; R2，R3和R4分别表示氢原子或含有1-4个碳原子的烷基，条件是R3和R4同时不为氢原子; R5和R6分别表示含有1-4个碳原子的烷基; R7表示氢原子，羟基，含有1-4个碳原子的烷基或含有1-4个碳原子的烷氧基。 主要包含上述衍生物的新型药物对于治疗过敏性疾病是有效的。
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5.发明授权
公开(公告)号：US4490362A
公开(公告)日：1984-12-25
申请号：US382364
申请日：1982-05-26
IPC分类号： A61K36/47 , A61K38/00 , A61K38/16 , A61K39/39 , A61K45/00 , A61P37/00 , A61K37/02 , A61K39/00
CPC分类号： A61K45/05 , A61K38/168 , A61K39/39 , A61K2039/55516
摘要： An immunopotentiator comprising the B chain of ricin as an active ingredient. The immunopotentiator serves to increase immune response to fungi, viruses and other microorganisms and is therefore effective for prevention or treatment of infectious diseases by such microorganisms.
摘要翻译： 一种包含蓖麻毒素B链作为活性成分的免疫增强剂。 免疫增强剂用于增加对真菌，病毒和其它微生物的免疫应答，因此可有效预防或治疗这些微生物的感染性疾病。
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6.发明授权Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases 有权内毒素 - 吸附剂用于预防和治疗自身免疫性疾病公开(公告)号：US07799347B2
公开(公告)日：2010-09-21
申请号：US11518393
申请日：2006-09-07
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供一种内毒素吸附剂，其能够除去胃肠道内的内毒素并且可以安全地施用于人。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，并且因此安全的内毒素吸附剂，用于去除存在于胃肠道中的大量内毒素，可以预防和治疗自身免疫疾病，例如 类风湿关节炎。
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公开(公告)号：US3987164A
公开(公告)日：1976-10-19
申请号：US493620
申请日：1974-07-31
申请人： Yuzuru Homma , Chiyoji Abe , Hiroshi Shionoya
发明人： Yuzuru Homma , Chiyoji Abe , Hiroshi Shionoya
IPC分类号： A61K38/00 , A61K39/00 , A61K39/104 , C07K14/21 , A61K39/02
CPC分类号： A61K39/104 , C07K14/21 , A61K38/00 , A61K39/00
摘要： The invention involves vaccine preparations comprising cell wall protein component of Pseudomonas aeruginosa as active ingredient and a pharmaceutically acceptable carrier. The preparations are suitable for parenteral administration for prophylactic treatment of disease caused by infection of Pseudomonas aeruginosa. The cell wall protein component is characterized by the fact that the same exhibits low toxicity and without type-specificity to the variety of antigens of Pseudomonas aeruginosa.
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8.发明授权公开(公告)号：US08287911B2
公开(公告)日：2012-10-16
申请号：US12804945
申请日：2010-08-02
CPC分类号： A61K39/39 , A61K2039/541 , A61K2039/55572
摘要： It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.
摘要翻译： 据信存在于胃肠道中的内毒素的异常吸收涉及自身免疫性疾病如类风湿性关节炎的发病机理。 在类风湿性关节炎的动物模型中，观察到通过去除内毒素来改善关节炎。 本发明提供一种内毒素吸附剂，其能够除去胃肠道内的内毒素并且可以安全地施用于人。 通过使用具有高内毒素结合能力的不可消化和不可吸收的，因而具有高的内毒素结合能力来去除存在于胃肠道中的大量内毒素的安全的内毒素吸附剂，可以预防和治疗自身免疫性疾病，例如 类风湿关节炎。
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9.发明申请Functional Composition Or Food Comprising Whey Protein, Antibody Derived From Milk Or Antibody 审中-公开功能组成或包含乳清蛋白的食物，由牛奶或抗体衍生的抗体公开(公告)号：US20070207187A1
公开(公告)日：2007-09-06
申请号：US11663248
申请日：2005-09-27
申请人： Mizuo Yajima , Satoshi Iwatsuki , Hiroshi Shionoya , Kuniaki Terado , Hirohisa Akamatsu , Shuuka Suzuki , Masamichi Katoh
发明人： Mizuo Yajima , Satoshi Iwatsuki , Hiroshi Shionoya , Kuniaki Terado , Hirohisa Akamatsu , Shuuka Suzuki , Masamichi Katoh
IPC分类号： A61K39/395 , A61K35/74 , A61K39/02 , A61K36/09
CPC分类号： A61K36/82 , A23C9/12 , A23C21/08 , A23C2230/15 , A23G1/42 , A23G1/56 , A23G9/36 , A23G2200/10 , A23G2200/12 , A23J3/08 , A23L2/02 , A23L2/66 , A23L27/84 , A23L33/10 , A23L33/135 , A23L33/14 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K36/185 , A61K36/42 , A61K36/45 , A61K36/73 , A61K36/752 , A61K36/81 , A61K36/886 , A61K36/899 , A61K36/9066 , A61K38/446 , A61K2039/505 , A61K2039/507 , C07K16/04 , C07K16/1203 , C07K16/18 , A61K2300/00 , A23V2250/54252 , A23V2250/21 , A23V2250/2102 , A23V2250/2106
摘要： There is provided a functional composition or food comprising whey protein, an antibody derived from milk or the other antibody; and a whey protein food comprising whey protein and glucide, cocoa powder, powdery an unsolidifiable and insoluble substance, green tea, aloe, turmeric, pumpkin, red grape juice, tomato, cranberry, raspberry, blueberry or strawberry powder.
摘要翻译： 提供了包含乳清蛋白，衍生自乳或其他抗体的抗体的功能组合物或食品; 和包含乳清蛋白质和糖浆的可可粉蛋白质，可粉粉末，不溶性和不溶性物质，绿茶，芦荟，姜黄，南瓜，红葡萄汁，番茄，蔓越莓，覆盆子，蓝莓或草莓粉末。
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公开(公告)号：US07150870B2
公开(公告)日：2006-12-19
申请号：US10655567
申请日：2003-09-04
申请人： Futoshi Okada , Masuo Hosokawa , Hiroshi Shionoya
发明人： Futoshi Okada , Masuo Hosokawa , Hiroshi Shionoya
CPC分类号： A61K38/446 , A61K38/168 , C12Y115/01001 , A61K2300/00
摘要： The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of preventing or treating the tumor.
摘要翻译： 本发明通过提供含有经处理的SOD作为活性成分的抗肿瘤剂，特别是用麦醇溶蛋白包被的甜瓜SOD来预防或治疗肿瘤，抑制肿瘤生长和恶性进展。 本发明也适用于预防或治疗肿瘤的方法。
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