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公开(公告)号：US20220323353A1
公开(公告)日：2022-10-13
申请号：US17620167
申请日：2019-06-19
申请人： Elena AFONINA , Hiep DO , Emily GOEL , Oleg GURYEV , Cyal LECY , Majid MEHRPOUYAN , Michael RANDALL , Marybeth SHARKEY , Jeffrey WANG , Becton, Dickinson and Company
发明人： Elena Afonina , Hiep Q Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
IPC分类号： A61K9/127 , A61K9/16 , A61K31/704 , A61K31/44
摘要： Drug-loaded microbead compositions including a plurality of individual microbeads of a biodegradable material, a plurality of individual vesicular agents, a first therapeutic agent, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include at least one lipid bilayer surrounding a vesicular core. The first therapeutic agent is associated with the individual vesicular agents. For example, the first therapeutic agent may be contained within the individual vesicular agents or may be associated with the individual vesicular agents by ionic or non-covalent interaction. The second therapeutic agent is different from the first therapeutic agent and contained within the individual microbeads or associated with the individual microbeads through ionic or non-covalent interaction. The second therapeutic agent may or may not be associated with the individual vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent associated with N the microbeads.
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公开(公告)号：US10736847B2
公开(公告)日：2020-08-11
申请号：US16026999
申请日：2018-07-03
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US11191725B2
公开(公告)日：2021-12-07
申请号：US16916991
申请日：2020-06-30
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US10556216B2
公开(公告)日：2020-02-11
申请号：US15472053
申请日：2017-03-28
发明人： Oleg Guryev , Tatyana Chernenko , Marybeth Sharkey
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US20210190790A1
公开(公告)日：2021-06-24
申请号：US17126583
申请日：2020-12-18
发明人： Majid Mehrpouyan , Oleg Guryev
IPC分类号： G01N33/58
摘要： Methods of quantitating extra-cellular vesicle surface markers are provided. Aspects of the methods include comparing: a mean fluorescence intensity of a surface marker of interest (surface marker MFI) of a labeled extra-cellular vesicle (EV) sample with a calibration plot obtained from a liposome calibration composition to quantitate the surface marker on extra-cellular vesicles of the EV sample. Also provided are compositions that find use in practicing embodiments of the invention.
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公开(公告)号：US20150362484A1
公开(公告)日：2015-12-17
申请号：US14755763
申请日：2015-06-30
发明人： Majid Mehrpouyan , Oleg Guryev , Marybeth Sharkey
CPC分类号： G01N33/5306 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/805
摘要： Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein. Also provided are methods of making, methods of use, systems and kits related to the subject fluorescent compositions.
摘要翻译： 提供发色团组合物及其制备和使用方法。 发色组合物的方面包括具有与金属蛋白的假体组结合腔稳定相关的发色团的发色团组分，例如荧光染料部分。 还提供了与本发明荧光组合物相关的制备方法，使用方法，系统和试剂盒。
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公开(公告)号：US09110070B2
公开(公告)日：2015-08-18
申请号：US14177134
申请日：2014-02-10
发明人： Majid Mehrpouyan , Oleg Guryev , Marybeth Sharkey
IPC分类号： G01N33/58
CPC分类号： G01N33/5306 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/805
摘要： Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein. Also provided are methods of making, methods of use, systems and kits related to the subject fluorescent compositions.
摘要翻译： 提供发色团组合物及其制备和使用方法。 发色组合物的方面包括具有与金属蛋白的假体组结合腔稳定相关的发色团的发色团组分，例如荧光染料部分。 还提供了与本发明荧光组合物相关的制备方法，使用方法，系统和试剂盒。
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公开(公告)号：US20140234855A1
公开(公告)日：2014-08-21
申请号：US14177134
申请日：2014-02-10
发明人： Majid Mehrpouyan , Oleg Guryev , Marybeth Sharkey
IPC分类号： G01N33/58
CPC分类号： G01N33/5306 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/805
摘要： Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein. Also provided are methods of making, methods of use, systems and kits related to the subject fluorescent compositions.
摘要翻译： 提供发色团组合物及其制备和使用方法。 发色组合物的方面包括具有与金属蛋白的假体组结合腔稳定相关的发色团的发色团组分，例如荧光染料部分。 还提供了与本发明荧光组合物相关的制备方法，使用方法，系统和试剂盒。
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公开(公告)号：US20220091132A1
公开(公告)日：2022-03-24
申请号：US17395143
申请日：2021-08-05
发明人： Oleg Guryev , Majid Mehrpouyan
IPC分类号： G01N33/68
摘要： Methods of determining whether a sample includes an antibody that binds to a coronaviral antigen are provided. Aspects of the methods may include combining the sample, a mammalian cell displaying on a surface thereof an antigenic determinant of the coronaviral antigen that is specifically bound by the antibody, and a labeled secondary binding member that binds to the antibody to produce an assay composition; and flow cytometrically assaying the assay composition for the presence of a signal from the labeled secondary binding member to determine whether the sample includes the antibody. Also provided are methods of assessing a subject for an immune response to a coronaviral infection and methods of producing a mammalian cell displaying on a surface thereof an antigenic determinant of a coronaviral antigen. Also provided are systems, expression vectors, mammalian cells, and kits for practicing the subject methods.
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公开(公告)号：US11278495B2
公开(公告)日：2022-03-22
申请号：US16916977
申请日：2020-06-30
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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