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公开(公告)号：US20220323353A1
公开(公告)日：2022-10-13
申请号：US17620167
申请日：2019-06-19
申请人： Elena AFONINA , Hiep DO , Emily GOEL , Oleg GURYEV , Cyal LECY , Majid MEHRPOUYAN , Michael RANDALL , Marybeth SHARKEY , Jeffrey WANG , Becton, Dickinson and Company
发明人： Elena Afonina , Hiep Q Do , Emily Goel , Oleg Guryev , Cyal Lecy , Majid Mehrpouyan , Michael Randall , Marybeth Sharkey , Jeffrey Wang
IPC分类号： A61K9/127 , A61K9/16 , A61K31/704 , A61K31/44
摘要： Drug-loaded microbead compositions including a plurality of individual microbeads of a biodegradable material, a plurality of individual vesicular agents, a first therapeutic agent, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include at least one lipid bilayer surrounding a vesicular core. The first therapeutic agent is associated with the individual vesicular agents. For example, the first therapeutic agent may be contained within the individual vesicular agents or may be associated with the individual vesicular agents by ionic or non-covalent interaction. The second therapeutic agent is different from the first therapeutic agent and contained within the individual microbeads or associated with the individual microbeads through ionic or non-covalent interaction. The second therapeutic agent may or may not be associated with the individual vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent associated with N the microbeads.
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公开(公告)号：US20150087005A1
公开(公告)日：2015-03-26
申请号：US14364055
申请日：2012-12-17
发明人： Majid Mehrpouyan , Marybeth Sharkey
CPC分类号： G01N1/44 , C07K16/2803 , G01N33/491 , G01N33/56972 , G01N33/582 , G01N2333/70596
摘要： The present invention provides labeling and capture reagents that comprise phosphorothioate oligonucleotides ODN). The PS-ODN bind to all white blood cells (leukocytes) in an indiscriminative fashion and enable the labeling, capture, or concentration of leukocytes in a manner that preserves the antigenic integrity of the cells. Methods for the use of phosphorothioate oligonucleotides are provided.
摘要翻译： 本发明提供包含硫代磷酸酯寡核苷酸ODN的标记和捕获试剂。 PS-ODN以不分皂白的方式结合所有白细胞（白细胞），并能以保持细胞抗原完整性的方式标记，捕获或浓缩白细胞。 提供了使用硫代磷酸酯寡核苷酸的方法。
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公开(公告)号：US10736847B2
公开(公告)日：2020-08-11
申请号：US16026999
申请日：2018-07-03
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US10545137B2
公开(公告)日：2020-01-28
申请号：US15490697
申请日：2017-04-18
发明人： Marybeth Sharkey , Shumeye Mamo
摘要： Multiplex polymeric dye devices are provided. Aspects of the devices include a solid support, and first and second dried polymeric dye compositions distinctly positioned relative to a surface of the solid support. Aspects of the invention further include methods of making and using the devices, e.g., in analyte detection applications, as well as kits containing the devices.
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公开(公告)号：US20170307600A1
公开(公告)日：2017-10-26
申请号：US15490697
申请日：2017-04-18
发明人： Marybeth Sharkey , Shumeye Mamo
摘要： Multiplex polymeric dye devices are provided. Aspects of the devices include a solid support, and first and second dried polymeric dye compositions distinctly positioned relative to a surface of the solid support. Aspects of the invention further include methods of making and using the devices, e.g., in analyte detection applications, as well as kits containing the devices.
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公开(公告)号：US20170097348A1
公开(公告)日：2017-04-06
申请号：US15384212
申请日：2016-12-19
发明人： Majid Mehrpouyan , Shumeye Mamo , Marybeth Sharkey
CPC分类号： G01N33/566 , B01J13/08 , C08J3/05 , C08J2365/00 , C08J2367/04 , C09K11/025 , C09K11/06 , C09K2211/14 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/705
摘要： Described herein are aqueous soluble polymersomes that encapsulate one or more hydrophobic fluorescent polymers and methods of their preparation and use.
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公开(公告)号：US09347863B2
公开(公告)日：2016-05-24
申请号：US14364055
申请日：2012-12-17
发明人： Majid Mehrpouyan , Marybeth Sharkey
IPC分类号： G01N1/44 , G01N33/49 , C07K16/28 , G01N33/569 , G01N33/58
CPC分类号： G01N1/44 , C07K16/2803 , G01N33/491 , G01N33/56972 , G01N33/582 , G01N2333/70596
摘要： The present invention provides labeling and capture reagents that comprise phosphorothioate oligonucleotides (PS-ODN). The PS-ODN bind to all white blood cells (leukocytes) in an indiscriminative fashion and enable the labeling, capture, or concentration of leukocytes in a manner that preserves the antigenic integrity of the cells. Methods for the use of phosphorothioate oligonucleotides are provided.
摘要翻译： 本发明提供包含硫代磷酸酯寡核苷酸（PS-ODN）的标记和捕获试剂。 PS-ODN以不分皂白的方式结合所有白细胞（白细胞），并能以保持细胞抗原完整性的方式标记，捕获或浓缩白细胞。 提供了使用硫代磷酸酯寡核苷酸的方法。
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公开(公告)号：US11191725B2
公开(公告)日：2021-12-07
申请号：US16916991
申请日：2020-06-30
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US10556216B2
公开(公告)日：2020-02-11
申请号：US15472053
申请日：2017-03-28
发明人： Oleg Guryev , Tatyana Chernenko , Marybeth Sharkey
摘要： Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号：US09863947B2
公开(公告)日：2018-01-09
申请号：US15384212
申请日：2016-12-19
发明人： Majid Mehrpouyan , Shumeye Mamo , Marybeth Sharkey
CPC分类号： G01N33/566 , B01J13/08 , C08J3/05 , C08J2365/00 , C08J2367/04 , C09K11/025 , C09K11/06 , C09K2211/14 , G01N21/6428 , G01N33/582 , G01N2021/6439 , G01N2333/705
摘要： Described herein are aqueous soluble polymersomes that encapsulate one or more hydrophobic fluorescent polymers and methods of their preparation and use.
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