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公开(公告)号：US20240198002A1
公开(公告)日：2024-06-20
申请号：US18589843
申请日：2024-02-28
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Robert Jonathan CAIN , Michael Funk CHIAPPETTA , Jeffrey LeClair ELLIS , David Arthur HOLLEY , Mark LAFEVER , Beverly Ann PIATT , John Paul TALLARICO
CPC分类号： A61M5/2046 , A61M2005/2073 , A61M2005/3125 , A61M2205/0216 , A61M2205/7536
摘要： Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.
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公开(公告)号：US20230364353A1
公开(公告)日：2023-11-16
申请号：US18044657
申请日：2021-09-01
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Yelena N. DAVIS , Jeffrey LeClair ELLIS , David Arthur HOLLEY , John Paul TALLARICO , Jessica Diane YOUNG
CPC分类号： A61M5/3234 , A61M39/26 , A61M5/2053 , A61M2205/36 , A61M2205/50
摘要： A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing. The therapeutic agent delivery assembly includes a chamber including a first passageway, a therapeutic agent carried in the first passageway, and a needle in communication with the first passageway. The therapeutic agent delivery assembly is translatable relative to the housing from a stowed configuration to a deployed configuration. The therapeutic agent delivery assembly is also translatable relative to the housing from the deployed configuration to a retracted configuration. The system further includes a user input that is actuatable to translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. The system further includes a retraction mechanism that is actuatable to translate the therapeutic agent delivery assembly from the deployed configuration to the retracted configuration.
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公开(公告)号：US20220111147A1
公开(公告)日：2022-04-14
申请号：US17299850
申请日：2019-12-12
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Jeffrey LeClair ELLIS , David Arthur HOLLEY , Beverly Ann PIATT , John Paul TALLARICO
摘要： A therapeutic agent delivery system comprises a housing. A therapeutic agent delivery assembly is carried by the housing. The therapeutic agent delivery assembly comprises a chamber having a passageway. A therapeutic agent is carried in the passageway, and a needle is in communication with the passageway. The therapeutic agent delivery assembly may be translatable relative to the housing from a stowed configuration to a deployed configuration. Actuation of a user input may translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. An input restraint may be rotatable relative to the housing from a first rotational configuration to a second rotational configuration. In the first rotational configuration the input restraint may inhibit actuation of the user input, and in the second rotational configuration the input restraint may permit actuation of the user input.
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公开(公告)号：US20240009403A1
公开(公告)日：2024-01-11
申请号：US18044597
申请日：2021-09-01
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Yelena N. DAVIS , David Arthur HOLLEY , John Paul TALLARICO , Jessica Diane YOUNG
CPC分类号： A61M5/3234 , A61M5/3157
摘要： A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing. The therapeutic agent delivery assembly includes a chamber including a passageway, a therapeutic agent carried in the passageway, and a needle in communication with the passageway. The therapeutic agent delivery assembly is translatable relative to the housing from a stowed configuration to a deployed configuration, and from the deployed configuration to a retracted configuration. The system further includes a user input configured to be actuated by a user, and actuation of the user input translates the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. The system further includes a retraction mechanism that translates the therapeutic agent delivery assembly from the deployed configuration to the retracted configuration.
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公开(公告)号：US20210038816A1
公开(公告)日：2021-02-11
申请号：US16645320
申请日：2018-08-31
发明人： Corrie Jo BENNISON , Anthony David DUONG , Jeffrey LeClair ELLIS , Michael W. HARRISON , Lampros C. KOURTIS , Rhea SIRKAR , John Paul TALLARICO
摘要： A chemical reaction system is disclosed for use in a device for delivering a therapeutic fluid comprising a liquid base and a polymeric acid. A reaction rate of the chemical reaction system is capable of being adjusted by adjusting at least one of surface area-to-volume ratio, acid concentration, and cross-linking of the polymeric acid.
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公开(公告)号：US20230398299A1
公开(公告)日：2023-12-14
申请号：US18044618
申请日：2021-09-01
发明人： William Godwin ATTERBURY , Timothy Mark BLUM , Yelena N. DAVIS , David Arthur HOLLEY , John Paul TALLARICO , Jessica Diane YOUNG
CPC分类号： A61M5/2033 , A61M5/322
摘要： A therapeutic agent delivery system includes a therapeutic agent delivery assembly carried by a housing. The therapeutic agent delivery assembly includes a chamber including a first passageway, a therapeutic agent carried in the first passageway, and a needle in communication with the first passageway. The therapeutic agent delivery assembly is translatable relative to the housing from a stowed configuration to a deployed configuration. In the deployed configuration the needle at least partially extends distally from the distal end portion of the housing. The therapeutic agent delivery assembly is translatable relative to the housing from the deployed configuration to a retracted configuration. In the retracted configuration the needle is disposed proximally relative to the distal end portion of the housing. A drive mechanism translates the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration and from the deployed configuration to the retracted configuration.
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公开(公告)号：US20210361880A1
公开(公告)日：2021-11-25
申请号：US17311117
申请日：2019-12-12
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Jeffrey Richard HELD , David Arthur HOLLEY , Noah John Scott LEMIRE , Beverly Anne PIATT , John Paul TALLARICO
摘要： A therapeutic agent delivery system (10) includes a housing (16) and a drive wheel (38) rotatably carried by the housing. A plunger rod (50) may be rotatable with the drive wheel relative to the housing from a first rotational configuration to a second rotational configuration. The plunger rod may be translatable relative to the housing from a first translational configuration to a second translational configuration. A plunger restraint (58) may maintain the plunger rod in the first translational configuration when the plunger rod is disposed in the first rotational configuration. The plunger restraint may permit the plunger rod to translate to the second translational configuration when the plunger rod is disposed in the second rotational configuration. A needle may move from a stowed configuration to a deployed configuration by the plunger rod when the plunger rod moves from the first translational configuration to the second translational configuration.
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公开(公告)号：US20200030537A1
公开(公告)日：2020-01-30
申请号：US16484676
申请日：2018-02-09
发明人： William Godwin ATTERBURY , Corrie Jo BENNISON , Robert Jonathan CAIN , Michael Funk CHIAPPETTA , Jeffrey LeClair ELLIS , David Arthur HOLLEY , Mark LAFEVER , Beverly Ann PIATT , John Paul TALLARICO
IPC分类号： A61M5/20
摘要： Processes and devices are disclosed for parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. The device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.
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