公开(公告)号：US4090776A

公开(公告)日：1978-05-23

申请号：US731862

申请日：1976-10-13

申请人： Enrique Bernal G. ,  Di Chen ,  Barry G. Koepke ,  James David Zook

发明人： Enrique Bernal G. ,  Di Chen ,  Barry G. Koepke ,  James David Zook

IPC分类号： C03B27/012 ,  C03B32/00 ,  G02B6/13 ,  G02B5/14

CPC分类号： C03B32/00 ,  C03B27/012 ,  G02B6/13

摘要： Optical waveguides are fabricated by heating a region of a body of flat filter glass with an energy beam such as a scanning focused laser beam. The region is locally heated to a temperature at which softening occurs. Upon cooling two differing effects occur, the two effects causing a "W" shaped index of refraction profile. The first effect is the photoelastic effect due to the residual stress introduced as the heated material cools and contracts. The residual tensile stress is constant in the softened region, but decreases as the distance from the center of the heating increases. Since the density and therefore the refractive index of this region is inversely proportional to the residual stress, this effect resulted in a local refractive index minimum. The other effect is the material density change in the softened region. As the cooling rate is small in the center and large in the edge of this softened region, a density change occurs with the center attaining the highest value and decrease towards the edge. The refractive index change due to this effect is proportional to the density and therefore resulted in a peak. The combined result of these two effects produces a "W" shape refractive index profile.

摘要翻译： 通过用诸如扫描聚焦激光束的能量束加热扁平滤光器玻璃体的区域来制造光波导。 该区域被局部加热到软化发生的温度。 冷却时，会发生两种不同的影响，这两种效应造成“W”形折射率折射率分布。 第一个效果是由于当加热材料冷却和收缩时引入的残余应力引起的光弹效应。 残余拉伸应力在软化区域是恒定的，但随着加热中心的距离增加而减小。 由于该区域的密度和因此的折射率与残余应力成反比，所以该效应导致局部折射率最小。 另一个效果是软化区域的材料密度变化。 随着中心的冷却速度小，软化区域的边缘较大，随着中心达到最高值并向边缘减小，发生密度变化。 由于这种效应导致的折射率变化与密度成比例，因此导致峰值。 这两种效应的组合结果产生“W”形折射率分布。

公开(公告)号：US4271104A

公开(公告)日：1981-06-02

申请号：US103247

申请日：1979-12-13

申请人： Rogers H. Anderson ,  Enrique Bernal G. ,  Di Chen

发明人： Rogers H. Anderson ,  Enrique Bernal G. ,  Di Chen

IPC分类号： G02B6/04 ,  G02B6/44 ,  B29D11/00

CPC分类号： G02B6/4403 ,  G02B6/448

摘要： A method of hot rolling or extrusion of a textured-surface sheet can be used to produce a large one dimensional array of fibers; these arrays can be stacked to form the two dimensional matrix required for image transfer. Alternatively, a flat ribbon can be rolled or extruded and the fiber array formed from it by altering the refractive index of alternate strips using diffusion ion exchange or implantation methods.

摘要翻译： 纹理表面片材的热轧或挤出方法可用于制造大的一维纤维阵列; 这些阵列可以堆叠形成图像传输所需的二维矩阵。 或者，可以通过使用扩散离子交换或注入方法改变替代条的折射率来平坦的带状物可以被卷起或挤出并且由其形成纤维阵列。

公开(公告)号：US4086001A

公开(公告)日：1978-04-25

申请号：US540919

申请日：1975-01-13

申请人： Di Chen ,  Barry G. Koepke

发明人： Di Chen ,  Barry G. Koepke

IPC分类号： C03B27/012 ,  G02B6/13 ,  G02B5/14

CPC分类号： G02B6/13 ,  C03B27/012

摘要： A thin optical waveguide is formed by a waveguide region having an index of refraction greater than the index of refraction of the substrate. The greater index of refraction of the waveguide region is a result of residual stress within the waveguide region.

摘要翻译： 薄的光波导由具有比基板的折射率大的折射率的波导区域形成。 波导区域的较大的折射率是波导区域内的残余应力的结果。

公开(公告)号：US09480375B2

公开(公告)日：2016-11-01

申请号：US14191299

申请日：2014-02-26

申请人： Jeffrey S. Marshall ,  Darren Hitt ,  Jun-ru Wu ,  Nicholas M. Vachon ,  Di Chen

发明人： Jeffrey S. Marshall ,  Darren Hitt ,  Jun-ru Wu ,  Nicholas M. Vachon ,  Di Chen

IPC分类号： A47L9/02 ,  A47L9/08

CPC分类号： A47L9/02 ,  A47L9/08

摘要： The invention disclosed herein provides for high particle removal rate and/or heat transfer from surfaces. The device removes particulate matter from a surface using a bounded vortex generated over the surface, with suction in the vortex center and jets for blowing air along the periphery. The jets are tilted in the tangential direction to induce vortex motion within the suction region. The vortex is said to be bounded because streamlines originating in the downward jets are entrained back into the central vortex.

摘要翻译： 本文公开的本发明提供了高的颗粒去除速率和/或表面的热传递。 该装置使用在表面上产生的有界涡旋从表面去除颗粒物质，并且在涡流中心具有吸力并且沿周边吹送空气的喷嘴。 喷嘴在切向方向上倾斜以在吸力区域内引起涡流运动。 涡流被认为是有界的，因为起源于向下喷射的流线被夹带回中心涡流。

公开(公告)号：US20140289997A1

公开(公告)日：2014-10-02

申请号：US14191299

申请日：2014-02-26

申请人： Jeffrey S. Marshall ,  Darren Hitt ,  Jun-ru Wu ,  Nicholas M. Vachon ,  Di Chen

发明人： Jeffrey S. Marshall ,  Darren Hitt ,  Jun-ru Wu ,  Nicholas M. Vachon ,  Di Chen

IPC分类号： A47L9/02

CPC分类号： A47L9/02 ,  A47L9/08

摘要： The invention disclosed herein provides for high particle removal rate and/or heat transfer from surfaces. The device removes particulate matter from a surface using a bounded vortex generated over the surface, with suction in the vortex center and jets for blowing air along the periphery. The jets are tilted in the tangential direction to induce vortex motion within the suction region. The vortex is said to be bounded because streamlines originating in the downward jets are entrained back into the central vortex.

摘要翻译： 本文公开的本发明提供了高的颗粒去除速率和/或表面的热传递。 该装置使用在表面上产生的有界涡旋从表面去除颗粒物质，并且在涡流中心具有吸力并且沿周边吹送空气的喷嘴。 喷嘴在切向方向上倾斜以在吸力区域内引起涡流运动。 涡流被认为是有界的，因为起源于向下喷射的流线被夹带回中心涡流。

公开(公告)号：US3997690A

公开(公告)日：1976-12-14

申请号：US581302

申请日：1975-05-27

申请人： Di Chen

发明人： Di Chen

IPC分类号： C04B35/491 ,  G02B1/10 ,  B05D5/06 ,  C04B35/46 ,  C23C15/00

CPC分类号： G02B1/10 ,  C04B35/491

摘要： Method for adjusting index of refraction of optical coating by heat treating. PLZT ceramic can be sputtered to form a thin film optical coating material for various optical applications. The fact that its refractive index can be adjusted by diffusion makes it particularly useful for antireflection coating or reflection coating on optical surfaces.

摘要翻译： 通过热处理调整光学涂层折射率的方法。 可以溅射PLZT陶瓷以形成用于各种光学应用的薄膜光学涂层材料。 其折射率可以通过扩散调节的事实使其特别适用于光学表面上的抗反射涂层或反射涂层。

公开(公告)号：US08695156B2

公开(公告)日：2014-04-15

申请号：US13024072

申请日：2011-02-09

申请人： Jeffrey S. Marshall ,  Di Chen ,  Nicholas Mario Vachon ,  Darren Hitt ,  Junru Wu

发明人： Jeffrey S. Marshall ,  Di Chen ,  Nicholas Mario Vachon ,  Darren Hitt ,  Junru Wu

IPC分类号： A47L5/14 ,  F15D1/00

CPC分类号： A47L5/14 ,  F15D1/00

摘要： The aero-acoustic duster invention disclosed herein provides for high particle removal rate from surfaces with low energy expenditure relative to competing vacuum-based devices. The device removes particulate matter from a surface using a two-step process: 1. Acoustic radiation is used to break the adhesive bonds between dust and the surface, forcing particles into a mode where they continuously bounce up and down on the surface; and, 2. A bounded vortex is generated over the surface, with suction in the vortex center and jets for blowing air along the periphery. The jets are tilted in the tangential direction to induce vortex motion within the suction region. The vortex is said to be bounded because streamlines originating in the downward jets are entrained back into the central vortex.

摘要翻译： 本文公开的气动声学除尘器发明提供了相对于竞争的基于真空的装置具有低能量消耗的表面的高颗粒去除速率。 该装置使用两步法从表面除去颗粒物：1.声辐射用于破坏灰尘和表面之间的粘合剂结合，迫使颗粒进入表面上下连续的模式; 并且，在表面上产生有界的涡流，在涡流中心具有吸力并且沿周边吹送空气的喷嘴。 喷嘴在切向方向上倾斜以在吸力区域内引起涡流运动。 涡流被认为是有界的，因为起源于向下喷射的流线被夹带回中心涡流。

公开(公告)号：US20110289605A1

公开(公告)日：2011-11-24

申请号：US13130490

申请日：2009-11-25

申请人： Di Chen

发明人： Di Chen

IPC分类号： A01K67/027 ,  A61K39/395 ,  A61K38/02 ,  A61K38/45 ,  A61P19/02 ,  G01N33/573 ,  A61K31/138 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/00 ,  A61K31/713 ,  A61P19/00

CPC分类号： A01K67/0275 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/035 ,  C12N15/8509 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated ligand binding domain of human estrogen receptor (CreER), wherein the first nucleic acid is operably linked to a chondrocyte-specific promoter and a second nucleic acid sequence encoding a β-catenin polypeptide, wherein the second nucleic acid sequence comprises one or more loxP sequences. Also provided is a method of modifying a transgenic animal comprising administering tamoxifen to the transgenic animal. Also provided are methods of screening for an agent that reduces or prevents Cre-Negative Control one or more symptoms of osteoarthritis or intervertebral disc disease in a subject. Methods for identifying a subject with or at risk of developing osteoarthritis or intervertebral disc disease are also provided, as well as methods of treating or preventing osteoarthritis or intervertebral disc disease in a subject.

摘要翻译： 本文提供了一种转基因动物，其基因组包含编码融合多肽的第一核酸序列，其中所述融合多肽包含Cre重组酶和人雌激素受体（CreER）的突变配体结合结构域，其中所述第一核酸可操作地连接到 软骨细胞特异性启动子和编码β-连环蛋白多肽的第二核酸序列，其中所述第二核酸序列包含一个或多个loxP序列。 还提供了修饰转基因动物的方法，其包括向转基因动物施用三苯氧胺。 还提供了筛选减少或预防Cre阴性对照在受试者中骨关节炎或椎间盘疾病的一种或多种症状的药剂的方法。 还提供了用于鉴定患有或具有发展为骨关节炎或椎间盘疾病的风险的受试者的方法，以及治疗或预防受试者中的骨关节炎或椎间盘疾病的方法。

公开(公告)号：US20110214246A1

公开(公告)日：2011-09-08

申请号：US13024072

申请日：2011-02-09

申请人： Jeffrey S. Marshall ,  Di Chen ,  Nicholas Mario Vachon ,  Darren Hitt ,  Junru Wu

发明人： Jeffrey S. Marshall ,  Di Chen ,  Nicholas Mario Vachon ,  Darren Hitt ,  Junru Wu

IPC分类号： A47L5/14 ,  F15D1/00

CPC分类号： A47L5/14 ,  F15D1/00

摘要： The aero-acoustic duster invention disclosed herein provides for high particle removal rate from surfaces with low energy expenditure relative to competing vacuum-based devices. The device removes particulate matter from a surface using a two-step process: 1. Acoustic radiation is used to break the adhesive bonds between dust and the surface, forcing particles into a mode where they continuously bounce up and down on the surface; and, 2. A bounded vortex is generated over the surface, with suction in the vortex center and jets for blowing air along the periphery. The jets are tilted in the tangential direction to induce vortex motion within the suction region. The vortex is said to be bounded because streamlines originating in the downward jets are entrained back into the central vortex.

摘要翻译： 本文公开的气动声学除尘器发明提供了相对于竞争的基于真空的装置具有低能量消耗的表面的高颗粒去除速率。 该装置使用两步法从表面除去颗粒物：1.声辐射用于破坏灰尘和表面之间的粘合剂结合，迫使颗粒进入表面上下连续的模式; 并且，在表面上产生有界的涡流，在涡流中心具有吸力并且沿周边吹送空气的喷嘴。 喷嘴在切向方向上倾斜以在吸力区域内引起涡流运动。 涡流被认为是有界的，因为起源于向下喷射的流线被夹带回中心涡流。

公开(公告)号：US20180142235A1

公开(公告)日：2018-05-24

申请号：US15356191

申请日：2016-11-18

申请人： Jianguang Zhang ,  Yang Gao ,  Yanbin Shi ,  Di Chen ,  Feng Tian

发明人： Jianguang Zhang ,  Yang Gao ,  Yanbin Shi ,  Di Chen ,  Feng Tian

IPC分类号： C12N15/10

CPC分类号： C12N15/1093 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q2521/501 ,  C12Q2525/191 ,  C12Q2531/113 ,  C12Q2535/122

摘要： The disclosure relates a method for constructing a plasma Deoxyribonucleic acid (DNA) sequencing library. The method includes: extracting a plasma DNA; making the plasma DNA ligate to a sequencing linker, and purifying a ligation product; performing Polymerase Chain Reaction (PCR) amplification for the purified ligation product, purifying the PCR amplification product, and obtaining the plasma DNA sequencing library, wherein, the method does not include the step of performing 5′-terminus phosphorylation for the plasma DNA. The kit provided by the disclosure includes: a reagent which ligates a plasma DNA to a sequencing linker, including the sequencing linker, a ligase and a ligation buffer; and reagents and instruments for purifying the ligation product; a reagent which performs PCR amplification for a purified ligation product, and reagents and instruments for purifying the PCR amplification product; wherein, the kit does not include the reagent which performs 5′-terminus phosphorylation for the plasma DNA.