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公开(公告)号：US06596279B1
公开(公告)日：2003-07-22
申请号：US09136159
申请日：1998-08-14
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C07K14/33 , C07K2319/00 , C12N15/86 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122 , C12N2770/24143
摘要： Attenuated recombinant viruses containing DNA encoding an immunodeficiency virus and/or CTL antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: HIV1gag(+pro)(IIIB), gp120(MN)(+transmembrane), nef(BRU)CTL, pol(IIIB)CTL, ELDKWA or LDKW epitopes, preferably HIV1gag(+pro)(IIIB), gp120(MN) (+transmembrane), two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL etpitopes; or two ELDKWA in gp120 V3 or another region or in gp160. The two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL epitopes are preferably CTL1, CTL2, pol1, pol2 and pol3. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. DNA from the recombinant viruses are useful as probes or, for generating PCR primers or for immunization. Also disclosed and claimed are HIV immunogens and modified gp160 and gp120.
摘要翻译： 公开并要求保护含有编码免疫缺陷病毒和/或CTL抗原的DNA的减毒重组病毒，以及使用病毒，其表达产物和由病毒或表达产物产生的抗体的方法和组合物。 重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码以下至少一种：HIV1gag（+ pro）（IIIB），gp120（MN）（+跨膜），nef（BRU）CTL，pol（IIIB）CTL，ELDKWA或LDKW表位，优选HIV1gag ）（IIIB），gp120（MN）（+跨膜），两（2）nef（BRU）CTL和三（3）pol（IIIB）CTL等位基因; 或gp120 V3或其他区域或gp160中的两个ELDKWA。 两个（2）nef（BRU）CTL和三（3）pol（IIIB）CTL表位优选为CTL1，CTL2，pol1，pol2和pol3。 来自其的重组病毒和基因产物以及由病毒和基因产物产生的抗体具有几种预防，治疗和诊断用途。 来自重组病毒的DNA可用作探针或用于产生PCR引物或用于免疫。 还公开并要求保护的是HIV免疫原和修饰的gp160和gp120。
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公开(公告)号：US20080188640A1
公开(公告)日：2008-08-07
申请号：US11891027
申请日：2007-08-08
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5254 , C07K14/33 , C07K2319/00 , C12N15/86 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2760/20122 , C12N2770/24022 , C12N2770/24122 , C12N2770/24143
摘要： Attenuated recombinant viruses containing DNA encoding an immunodeficiency virus and/or CTL antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: HIV1gag(+pro) (IIIB), gp120(MN) (+transmembrane), nef (BRU)CTL, pol(IIIB)CTL, ELDKWA or LDKW epitopes, preferably HIV1gag(+pro) (IIIB), gp120(MN) (+transmembrane), two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL epitopes; or two ELDKWA in gp120 V3 or another region or in gp160. The two (2) nef(BRU)CTL and three (3) pol(IIIB)CTL epitopes are preferably CTL1, CTL2, pol1, pol2 and pol3. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. DNA from the recombinant viruses are useful as probes or, for generating PCR primers or for immunization. Also disclosed and claimed are HIV immunogens and modified gp160 and gp120.
摘要翻译： 公开并要求保护含有编码免疫缺陷病毒和/或CTL抗原的DNA的减毒重组病毒，以及使用病毒，其表达产物和由病毒或表达产物产生的抗体的方法和组合物。 重组病毒可以是NYVAC或ALVAC重组病毒。 DNA可编码以下至少一种：HIV1gag（+ pro）（IIIB），gp120（MN）（+跨膜），nef（BRU）CTL，pol（IIIB）CTL，ELDKWA或LDKW表位，优选HIV1gag ）（IIIB），gp120（MN）（+跨膜），两（2）nef（BRU）CTL和三（3）pol（IIIB）CTL表位; 或gp120 V3或其他区域或gp160中的两个ELDKWA。 两个（2）nef（BRU）CTL和三（3）pol（IIIB）CTL表位优选为CTL1，CTL2，pol1，pol2和pol3。 来自其的重组病毒和基因产物以及由病毒和基因产物产生的抗体具有几种预防，治疗和诊断用途。 来自重组病毒的DNA可用作探针或用于产生PCR引物或用于免疫。 还公开并要求保护的是HIV免疫原和修饰的gp160和gp120。
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3.发明授权Characterization of replication competent human immunodeficiency type 2 proviral clone HIV-2.sub.SBL/ISY 失效复制人类免疫缺陷型2型病毒性HIV-2SBL / ISY的特征
公开(公告)号：US5223423A
公开(公告)日：1993-06-29
申请号：US331212
申请日：1989-03-31
CPC分类号： C12N7/00 , C07K14/005 , C12N15/8509 , A01K2217/05 , A01K2267/0337 , C12N2740/16021 , C12N2740/16022 , Y10S930/221
摘要： A complete genomic clone of HIV-2 designated HIV-2.sub.SBL/ISY was cloned from DNA of the neoplastic human cell line HUT78 infected with the HIV-2.sub.SBL6669 viral isolate. The clone was sequenced and the sequence compared with those of known HIV-2 isolates. The invention is advantageous for it provides an animal model for the study of HIV infection in man.
摘要翻译： 从HIV-2SBL6669病毒分离株感染的肿瘤人类细胞系HUT78的DNA中克隆了一个名为HIV-2SBL / ISY的完整的HIV-2基因组克隆。 对克隆进行测序，并将序列与已知的HIV-2分离株进行比较。 本发明有利于其提供用于人类中HIV感染研究的动物模型。
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公开(公告)号：US09483470B2
公开(公告)日：2016-11-01
申请号：US13470952
申请日：2012-05-14
申请人： Robert Gallo , Glen Gordon
发明人： Robert Gallo , Glen Gordon
IPC分类号： G06F17/30 , G06F3/0484 , G06F11/34
CPC分类号： G06F17/30011 , G06F3/0484 , G06F11/3438 , G06F17/30867
摘要： A document navigation tool that automatically navigates a document based on previous input from the user. The document navigation tool is utilized each time a page loads. The method recognizes user behavior on pages using patterns, which are based on four criterion: location, frequency, consistency, and scope. If the user has visited the page previously and has established a pattern, the method automatically focuses on the portion of the page indicated by the pattern, e.g. the location on a web page of the link clicked by the user in the user's last three visits to the page. If the user has not visited the page previously, the method logs the events that occur during this visit to the page.
摘要翻译： 一种文档导航工具，可根据用户以前的输入自动导航文档。 每次加载页面时都会使用文档导航工具。 该方法使用模式识别页面上的用户行为，这些模式基于四个标准：位置，频率，一致性和范围。 如果用户先前访问过页面并且已经建立了模式，则该方法自动地聚焦在由模式指示的页面的部分，例如， 用户在页面的最后三次访问中点击了该链接的网页上的位置。 如果用户以前没有访问该页面，则该方法将在此访问期间发生的事件记录到页面。
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公开(公告)号：US20130332815A1
公开(公告)日：2013-12-12
申请号：US13491799
申请日：2012-06-08
申请人： Robert Gallo , Glen Gordon
发明人： Robert Gallo , Glen Gordon
CPC分类号： G06F3/0481 , G06F3/011 , G06F3/16 , G06F17/2247 , G06F2203/04805 , G09B21/003 , G09B21/005 , G09B21/006 , G09B21/008
摘要： A screen reader application for visually impaired users suppresses unwanted content that is output by Braille or text-to-speech. The invention accesses, but does not modify, the document object model of the web page and enumerates web page elements for the end user to either hide or skip to. The end user selections are saved as rules which may be applied according to various levels of scope include web page specific, site specific or web-wide. A screen magnification application for visually impaired users automatically sets the visual focus and magnification level on a web page element according to end-user selection.
摘要翻译： 视觉受损用户的屏幕阅读器应用程序抑制由盲文或文本到语音输出的不需要的内容。 本发明访问但不修改网页的文档对象模型，并枚举最终用户要隐藏或跳过的网页元素。 最终用户选择被保存为根据不同级别的范围应用的规则，包括特定于网页，特定站点或网络范围的规则。 用于视障者的屏幕放大应用程序根据最终用户选择自动设置网页元素上的视觉焦点和放大级别。
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公开(公告)号：US20060052317A1
公开(公告)日：2006-03-09
申请号：US11250899
申请日：2005-10-14
申请人： Franco Lori , Andrea Cara , Wen-Yi Gao , Robert Gallo
发明人： Franco Lori , Andrea Cara , Wen-Yi Gao , Robert Gallo
IPC分类号： A61K31/7072 , A61K31/7076 , A61K31/19
CPC分类号： A61K31/708 , A61K31/17 , A61K31/19 , A61K31/70 , A61K31/7072 , A61K31/7076 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.
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公开(公告)号：US08209607B2
公开(公告)日：2012-06-26
申请号：US12759991
申请日：2010-04-14
申请人： Robert Gallo , Glen Gordon
发明人： Robert Gallo , Glen Gordon
IPC分类号： G06F3/00
CPC分类号： G06F17/30011 , G06F3/0484 , G06F11/3438 , G06F17/30867
摘要： A document navigation tool that automatically navigates a document based on previous input from the user. The document navigation tool is utilized each time a page loads. The method recognizes user behavior on pages using patterns, which are based on four criterion: location, frequency, consistency, and scope. If the user has visited the page previously and has established a pattern, the method automatically focuses on the portion of the page indicated by the pattern, e.g. the location on a web page of the link clicked by the user in the user's last three visits to the page. If the user has not visited the page previously, the method logs the events that occur during this visit to the page.
摘要翻译： 一种文档导航工具，可根据用户以前的输入自动导航文档。 每次加载页面时都会使用文档导航工具。 该方法使用模式识别页面上的用户行为，这些模式基于四个标准：位置，频率，一致性和范围。 如果用户先前访问过页面并且已经建立了模式，则该方法自动地聚焦在由模式指示的页面的部分，例如， 用户在页面的最后三次访问中点击了该链接的网页上的位置。 如果用户以前没有访问该页面，则该方法将在此访问期间发生的事件记录到页面。
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公开(公告)号：US20100262908A1
公开(公告)日：2010-10-14
申请号：US12759991
申请日：2010-04-14
申请人： Robert Gallo , Glen Gordon
发明人： Robert Gallo , Glen Gordon
IPC分类号： G06F3/01
CPC分类号： G06F17/30011 , G06F3/0484 , G06F11/3438 , G06F17/30867
摘要： A document navigation tool that automatically navigates a document based on previous input from the user. The document navigation tool is utilized each time a page loads. The method recognizes user behavior on pages using patterns, which are based on four criterion: location, frequency, consistency, and scope. If the user has visited the page previously and has established a pattern, the method automatically focuses on the portion of the page indicated by the pattern, e.g. the location on a web page of the link clicked by the user in the user's last three visits to the page. If the user has not visited the page previously, the method logs the events that occur during this visit to the page.
摘要翻译： 一种文档导航工具，可根据用户以前的输入自动导航文档。 每次加载页面时都会使用文档导航工具。 该方法使用模式识别页面上的用户行为，这些模式基于四个标准：位置，频率，一致性和范围。 如果用户先前访问过页面并且已经建立了模式，则该方法自动地聚焦在由模式指示的页面的部分，例如， 用户在页面的最后三次访问中点击了该链接的网页上的位置。 如果用户以前没有访问该页面，则该方法将在此访问期间发生的事件记录到页面。
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9.发明授权Chemokine—glycosaminoglycan complexes and their use in treating or preventing receptor mediated diseases 失效趋化因子 - 糖胺聚糖复合物及其在治疗或预防受体介导的疾病中的应用公开(公告)号：US06399078B1
公开(公告)日：2002-06-04
申请号：US09323719
申请日：1999-06-01
IPC分类号： A61K4700
CPC分类号： A61K38/195 , A61K47/61 , Y02A50/475 , Y02A50/48 , Y10S514/885
摘要： The present invention provides therapeutic compositions of receptor ligand-containing antagonist complexes and methods of using them to treat diseases, disorders or conditions associated with the function or aberrant function of a cell surface receptor.
摘要翻译： 本发明提供了含有受体配体的拮抗剂复合物的治疗组合物及其用于治疗与细胞表面受体的功能或异常功能相关的疾病，病症或病症的方法。
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公开(公告)号：US08862985B2
公开(公告)日：2014-10-14
申请号：US13491799
申请日：2012-06-08
申请人： Robert Gallo , Glen Gordon
发明人： Robert Gallo , Glen Gordon
CPC分类号： G06F3/0481 , G06F3/011 , G06F3/16 , G06F17/2247 , G06F2203/04805 , G09B21/003 , G09B21/005 , G09B21/006 , G09B21/008
摘要： A screen reader application for visually impaired users suppresses unwanted content that is output by Braille or text-to-speech. The invention accesses, but does not modify, the document object model of the web page and enumerates web page elements for the end user to either hide or skip to. The end user selections are saved as rules which may be applied according to various levels of scope include web page specific, site specific or web-wide. A screen magnification application for visually impaired users automatically sets the visual focus and magnification level on a web page element according to end-user selection.
摘要翻译： 视觉受损用户的屏幕阅读器应用程序抑制由盲文或文本到语音输出的不需要的内容。 本发明访问但不修改网页的文档对象模型，并枚举最终用户要隐藏或跳过的网页元素。 最终用户选择被保存为根据不同级别的范围应用的规则，包括特定于网页，特定站点或网络范围的规则。 用于视障者的屏幕放大应用程序根据最终用户选择自动设置网页元素上的视觉焦点和放大级别。
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