公开(公告)号：US11136561B2

公开(公告)日：2021-10-05

申请号：US16829204

申请日：2020-03-25

Applicant: Erber Aktiengesellschaft

Inventor： Juan Antonio Torres Acosta ,  Gerhard Adam ,  Elisavet Kunz-Vekiru ,  Wulf-Dieter Moll ,  Rudolf Mitterbauer ,  Clemens Schmeitzl

IPC: C12P17/08 ,  C12N9/02 ,  C12N1/19 ,  C12N15/53 ,  C12N15/82 ,  C12N15/81

Abstract: The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in position 7 of zearalenone into an ester group, the monooxygenase in particular being an amino acid sequence selected from the group comprising sequence ID No. 1, 2 and 3 or a functional variant thereof. The functional variant and at least one of the amino acid sequences has a sequence identity of at least 60%, preferably at least 70%, more preferably at least 80% and most preferably 90%.

公开(公告)号：US20230399674A1

公开(公告)日：2023-12-14

申请号：US18032312

申请日：2021-10-22

Applicant: ERBER AKTIENGESELLSCHAFT

Inventor： Wulf-Dieter Moll ,  Barbara Weber ,  Martin Siller

IPC: C12P41/00 ,  A23K20/147 ,  A23K20/189 ,  A23L5/20 ,  A23L33/18 ,  C12N9/04

CPC classification number: C12P41/00 ,  A23K20/147 ,  A23K20/189 ,  A23L5/25 ,  A23L33/18 ,  C12N9/0006 ,  C12Y101/01001

Abstract: The present invention relates to means and methods for degrading DON and/or DON derivative/s comprising a polypeptide comprising an amino acid sequence having at least 70% identity to the amino acid sequence set forth in SEQ ID NO: 1.

公开(公告)号：US20210371835A1

公开(公告)日：2021-12-02

申请号：US17264096

申请日：2019-07-30

Applicant: ERBER AKTIENGESELLSCHAFT

Inventor： Michaela Thamhesl ,  Sebastian Fruhauf ,  Wulf-Dieter Moll ,  Andreas Hoebartner ,  Gerd Schatzmayr ,  Eva Maria Binder ,  Markus Aleschko ,  Martin Pfeffer

IPC: C12N9/14 ,  A23K20/189 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  A23L29/00 ,  A23L33/10 ,  A23L33/00 ,  A61K38/46

Abstract: The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).

公开(公告)号：US20180298352A1

公开(公告)日：2018-10-18

申请号：US15524643

申请日：2015-11-04

Applicant: Erber Aktiengesellschaft

Inventor： Juan Antonio TORRES ACOSTA ,  Gerhard ADAM ,  Elisavet KUNZ-VEKIRU ,  Wulf-Dieter Moll ,  Rudolf MITTERBAUER ,  Clemens SCHMEITZL

IPC: C12N9/02 ,  C12P17/08 ,  C12N15/81

Abstract: The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in position 7 of zearalenone into an ester group, the monooxygenase in particular being an amino acid sequence selected from the group comprising sequence ID No. 1, 2 and 3 or a functional variant thereof. The functional variant and at least one of the amino acid sequences has a sequence identity of at least 60%, preferably at least 70%, more preferably at least 80% and most preferably 90%,