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公开(公告)号:US11324235B2
公开(公告)日:2022-05-10
申请号:US16934179
申请日:2020-07-21
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US20200375218A1
公开(公告)日:2020-12-03
申请号:US16934179
申请日:2020-07-21
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US20220287328A1
公开(公告)日:2022-09-15
申请号:US17829431
申请日:2022-06-01
发明人: Sebastian FRUHAUF , Michaela Thamhesl , Martin Pfeffer , Dleter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US10264807B2
公开(公告)日:2019-04-23
申请号:US15553218
申请日:2015-02-24
摘要: The invention relates to fusarium toxin-cleaving polypeptide variants of a fusarium toxin carboxyl esterase with the SEQ ID NO:46. Each of the polypeptide variants has an amino acid sequence shortened by 47 amino acids at the N terminus, and the amino acid sequences have at least 70%, preferably 80%, in particular 100%, sequence identity, namely SEQ ID NO:1, to the amino acid sequence portion 48-540 of the SEQ ID NO:46. The invention also relates to isolated polynucleotides which code for the polypeptide variants, to a fusarium toxin-cleaving additive containing at least one polypeptide variant and optionally at least one auxiliary agent, to the use of the polypeptide variants or the additive, and to a method for hydrolytically cleaving at least one fusarium toxin.
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公开(公告)号:US10149489B2
公开(公告)日:2018-12-11
申请号:US14914671
申请日:2014-08-27
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US20210371835A1
公开(公告)日:2021-12-02
申请号:US17264096
申请日:2019-07-30
发明人: Michaela Thamhesl , Sebastian Fruhauf , Wulf-Dieter Moll , Andreas Hoebartner , Gerd Schatzmayr , Eva Maria Binder , Markus Aleschko , Martin Pfeffer
IPC分类号: C12N9/14 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , A23L29/00 , A23L33/10 , A23L33/00 , A61K38/46
摘要: The present invention relates to a method for increasing the stability of an α/β-hydrolase. In addition, the present invention relates to an α/β-hydrolase obtainable by the method of the present invention. Also provided are α/β-hydrolases having a decreased grand average of hydropathy (GRAVY) value and/or comprising specific mutations. In addition, the present invention concerns a use of an α/β-hydrolase of the present invention for degrading zearalenone (ZEN).
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公开(公告)号:US20200338138A1
公开(公告)日:2020-10-29
申请号:US16955706
申请日:2018-12-19
IPC分类号: A61K35/741 , C12P7/42 , A23K10/18 , A23K50/30 , A23K50/60
摘要: The present invention relates to a use of a microorganism of the class Coriobacteriia for promoting gut health of a healthy subject. Also provided is a method for the production of chenodeoxycholic acid (CDCA) and a method for the production of lithocholic acid (LCA).
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公开(公告)号:US10779556B2
公开(公告)日:2020-09-22
申请号:US16161266
申请日:2018-10-16
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
IPC分类号: A23K10/14 , C12N9/14 , A23K50/75 , A23K50/30 , A23K50/80 , A23L3/3571 , C12N9/18 , C07K14/195
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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公开(公告)号:US10076125B2
公开(公告)日:2018-09-18
申请号:US15054232
申请日:2016-02-26
发明人: Sebastian Fruhauf , Michaela Thamhesl , Martin Pfeffer , Dieter Moll , Gerd Schatzmayr , Eva Maria Binder
CPC分类号: A23K10/14 , A23K50/30 , A23K50/75 , A23K50/80 , A23L3/3571 , A23V2002/00 , C12N9/14 , C12N9/18 , C12Y301/01 , Y02A40/818
摘要: The invention relates to a polypeptide for the hydrolytic cleavage of zearalenone and/or at least one zearalenone derivative, said polypeptide being a hydrolase having an amino acid sequence selected from the group consisting of SEQ ID NO: 1-15 or a functional variant thereof, wherein the sequence of the functional variant is at least 40% identical to at least one of the amino acid sequences. The invention also relates to: an additive containing the polypeptide; an isolated polynucleotide that encodes the polypeptide; and a method for the hydrolytic cleavage of zearalenone and/or of at least one zearalenone derivative using the polypeptide.
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