摘要:
A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.
摘要:
A system and method for validating data for a machine arrangement includes a controller, such as a programmable logic controller, connected to a processor, which is configured to execute an algorithm using the data collected by the controller. The algorithm includes one or more rules that are applicable to the collected data. Each rule is applied to the data to determine if any of the data entries violate one or more of the rules. An output is generated indicating whether the data violates any of the rules, thereby providing information regarding the validity of the data being captured.
摘要:
Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.
摘要:
Textual fault messages in PLC-based manufacturing systems are supplemented by automatically displayed sets of information that allow an operator to quickly identify, recognize and visualize components responsible for producing faults. Visual display of stored computer generated images showing system components and tooling allow the operator to visually pinpoint the exact component responsible for the fault, and its location within the manufacturing system. Stored information associated with the component producing the fault, such as installation date, vendor sources, replacement part inventory, programming logic and editing software, is also automatically recalled and displayed along with the fault message to aid fault diagnosis and correction.
摘要:
The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
摘要:
The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
摘要:
This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I. The invention includes pharmaceutical compositions comprising the compound of Formula I:
摘要:
This invention relates to a novel class of linear polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for their production. The compounds may be obtained by cultivation of Streptomyces melanosporafaciens species and isolation of the polyene polyketide, followed by optional chemical production of the isolated polyene polyketide. The compounds may also be produced by other known bacteria. The invention further includes the use of these compounds as inhibitors of fungal cell growth and inhibitors of cancer cell growth. Finally, the invention encompasses pharmaceutical compositions comprising these novel polyketide compounds, or their pharmaceutically acceptable salts or derivatives thereof.
摘要:
Described are methods and systems for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
摘要:
Novel polyene oxazole compounds of Formula I: are useful as cytotoxic agents. The polyene oxazoles may be made by fermentation of Streptomyces sparsogenes and optional post-biosynthesis chemical modification thereof.