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公开(公告)号：US20130202530A1
公开(公告)日：2013-08-08
申请号：US13825347
申请日：2011-09-20
申请人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao , David Turton , Anthony Wilson , Rajiv Bhalla , Diana Brickute
发明人： Eric Ofori Aboagye , Edward George Robins , Graham Smith , Yongjun Zhao , David Turton , Anthony Wilson , Rajiv Bhalla , Diana Brickute
IPC分类号： A61K51/04
CPC分类号： A61K51/04 , C07B59/001 , C07B2200/05 , C07C213/08 , C07C215/08 , C07C215/40 , Y10T428/13
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
摘要翻译： 用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）的新型放射性示踪剂与改变的胆碱代谢相关的疾病状态（例如，前列腺，乳腺，脑，食管，卵巢，子宫内膜，肺和 前列腺癌原发性肿瘤，淋巴结转移或转移）。 本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。
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公开(公告)号：US20130178653A1
公开(公告)日：2013-07-11
申请号：US13824438
申请日：2011-09-20
IPC分类号： C07C215/08 , C07C217/10
CPC分类号： C07C215/08 , C07B2200/05 , C07C217/10 , C07C309/73
摘要： The present invention describes intermediate(s), pre-cursor(s), for the preparation of radialabelled choline analogs to be used as radiotracers for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of diseases.
摘要翻译： 本发明描述了用于制备用于正电子发射断层扫描（PET）或疾病的单光子发射计算机断层成像（SPECT）成像的放射性示踪剂的径向标记的胆碱类似物的中间体，前体。
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公开(公告)号：US20130183239A1
公开(公告)日：2013-07-18
申请号：US13824547
申请日：2011-09-20
IPC分类号： A61K51/04 , C07C215/08
CPC分类号： A61K51/04 , C07B59/001 , C07B2200/05 , C07C215/08 , C07C215/40
摘要： Novel choline-derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases).
摘要翻译： 具有与用于正电子发射断层扫描（PET）的同位素碳的新型胆碱衍生的放射性示踪剂或与改变的胆碱代谢相关的疾病状态的单光子发射计算机断层摄影（SPECT）成像（例如，前列腺，乳腺，脑，食管的肿瘤成像 ，卵巢，子宫内膜，肺和前列腺癌原发性肿瘤，淋巴结转移或转移）。
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公开(公告)号：US08961930B2
公开(公告)日：2015-02-24
申请号：US13062064
申请日：2009-09-04
IPC分类号： A61K49/00 , C07D403/12 , C07D403/14 , C07D405/14 , A61K51/00 , A61M36/14
CPC分类号： C07D403/12 , C07D403/14 , C07D405/14
摘要： Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.
摘要翻译： 靛红5-磺酰胺衍生物，包含衍生物的药物组合物，其作为分子显像剂的用途，其用于诊断或治疗与凋亡失调相关的疾病或病症的用途，合成衍生物的方法，半胱天冬酶活性的分子成像方法 并且公开了细胞凋亡和评估测试物质对胱天蛋白酶活性的治疗效果的方法。
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5.发明申请NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS 审中-公开核素类似物可用作POSITRON排放成像（PET）成像剂公开(公告)号：US20110236312A1
公开(公告)日：2011-09-29
申请号：US13061701
申请日：2009-08-28
申请人： Eric Ofori Aboagye , Graham Smith
发明人： Eric Ofori Aboagye , Graham Smith
IPC分类号： A61K51/04 , C07F13/00 , C07D409/14 , C07F5/00 , C07F1/08 , A61P35/00 , A61P29/00 , A61P9/00 , C08F8/30 , C08G63/00 , C09D123/36
CPC分类号： C07H19/073 , C07H5/10 , C07H23/00
摘要： The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided.
摘要翻译： 本发明提供了包含4'-硫代胸苷或4'-硫代-2'-脱氧尿苷衍生物的4'-硫代核苷的化合物，其包含通过三唑连接物连接的正电子或单光子发射放射性同位素或相应的非放射性同位素 到N-3位置。 还提供了制备这些化合物的方法和该化合物在医药中的用途。
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公开(公告)号：US10201625B2
公开(公告)日：2019-02-12
申请号：US14002168
申请日：2012-03-01
申请人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
发明人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
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公开(公告)号：US08236985B2
公开(公告)日：2012-08-07
申请号：US12447006
申请日：2007-10-24
IPC分类号： C07C259/06 , A61K31/19
CPC分类号： C07C311/44
摘要： There is provided a compound of formula (I) wherein R1a, R2a, R3, X1 to X6, a, b and c have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, inhibitors of HDAC enzyme activity, and thus, in particular, in the treatment of conditions where inhibition of HDAC enzyme activity is required.
摘要翻译： 提供式（I）的化合物，其中R 1a，R 2a，R 3，X 1至X 6，a，b和c具有在说明书中给出的含义，哪些化合物可用作或可用作HDAC酶抑制剂的前药 活性，特别是治疗需要抑制HDAC酶活性的病症。
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公开(公告)号：US20130343990A1
公开(公告)日：2013-12-26
申请号：US14002168
申请日：2012-03-01
申请人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
发明人： Sajinker Kaur Luthra , Julius Leyton , Eric Ofori Aboagye , Lisa Iddon , Bard Indrevoll , Matthias Eberhard Glaser , Alan Cuthbertson
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/083 , A61K51/088 , C07B59/002 , C07B59/008
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) imaging are described. Novel radiotracer(s) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that target somatostatin receptors found on the cell surface of gastroenteropancreatic neuorendocrine tumors. The present invention also describes intermediate(s), precursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
摘要翻译： 描述了用于正电子发射断层扫描（PET）成像的新型放射性示踪剂。 描述了用于神经内分泌肿瘤的正电子发射断层扫描（PET）成像的新型放射性示踪剂。 具体地说，本发明描述了新颖的[18 F]氟乙基三唑 - [Tyr 3] Octreotate类似物; 特别是在胃肠胰腺内分泌肿瘤的细胞表面上发现的生长抑素受体的那些。 本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。
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公开(公告)号：US20100063144A1
公开(公告)日：2010-03-11
申请号：US12447006
申请日：2007-10-24
IPC分类号： A61K31/165 , A61K31/27 , A61K31/265 , A61K31/18 , C07C69/96 , C07C271/28 , C07C311/21 , A61P35/00 , C07C311/37 , A61P25/00 , A61P7/06 , A61P31/10 , A61P33/00 , A61P17/06 , A61P9/00
CPC分类号： C07C311/44
摘要： There is provided a compound of formula (I) wherein R1a, R2a, R3, X1 to X6, a, b and c have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, inhibitors of HDAC enzyme activity, and thus, in particular, in the treatment of conditions where inhibition of HDAC enzyme activity is required.
摘要翻译： 提供式（I）的化合物，其中R 1a，R 2a，R 3，X 1至X 6，a，b和c具有在说明书中给出的含义，哪些化合物可用作或可用作HDAC酶抑制剂的前药 活性，特别是治疗需要抑制HDAC酶活性的病症。
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