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公开(公告)号：US09061903B2
公开(公告)日：2015-06-23
申请号：US13119557
申请日：2009-10-02
申请人： Eric Tulsky , Eric Welch , Bruce Branchaud , John Mauro , Imad Naasani
发明人： Eric Tulsky , Eric Welch , Bruce Branchaud , John Mauro , Imad Naasani
CPC分类号： B82Y30/00 , B01J13/22 , B82Y40/00 , C09B68/42 , C09B68/4257 , C09B68/44 , C09B68/441 , C09B68/443 , C09K11/025 , C09K11/56
摘要： A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.
摘要翻译： 在其表面上具有一个或多个膦酸盐或次膦酸盐配体的纳米颗粒可以通过使含膦酸盐的纳米颗粒与甲硅烷基磺酸盐试剂接触而在其表面上转化成具有磺酸盐配体的纳米颗粒。 这样的纳米颗粒被激活成与亲核基团的反应; 因此该方法提供活化的纳米颗粒，以及制备和使用它们以产生改性纳米颗粒的方法。
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公开(公告)号：US20110220844A1
公开(公告)日：2011-09-15
申请号：US13119557
申请日：2009-10-02
申请人： Eric Tulsky , Eric Welch , Bruce Branchaud , John Mauro , Imad Naasani
发明人： Eric Tulsky , Eric Welch , Bruce Branchaud , John Mauro , Imad Naasani
CPC分类号： B82Y30/00 , B01J13/22 , B82Y40/00 , C09B68/42 , C09B68/4257 , C09B68/44 , C09B68/441 , C09B68/443 , C09K11/025 , C09K11/56
摘要： A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.
摘要翻译： 在其表面上具有一个或多个膦酸盐或次膦酸盐配体的纳米颗粒可以通过使含膦酸盐的纳米颗粒与甲硅烷基磺酸盐试剂接触而在其表面上转化成具有磺酸盐配体的纳米颗粒。 这样的纳米颗粒被激活成与亲核基团的反应; 因此该方法提供活化的纳米颗粒，以及制备和使用它们以产生改性纳米颗粒的方法。
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公开(公告)号：US08901333B2
公开(公告)日：2014-12-02
申请号：US13122094
申请日：2009-09-30
申请人： Eric Tulsky , Eric Welch , Bruce Branchaud , Roman Rozhkov
发明人： Eric Tulsky , Eric Welch , Bruce Branchaud , Roman Rozhkov
CPC分类号： C09K11/025 , C09K11/883 , Y10T428/2998
摘要： Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.
摘要翻译： 描述了具有包括纳米晶体结合中心和一个或多个共价连接的官能团或反应性官能团的多功能表面配体的有机表面层的涂覆的荧光半导体纳米颗粒以及具有有机表面层或多层结构的水分散性纳米颗粒， 功能性表面配体和用于制备和使用这种包被的纳米颗粒的方法。
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公开(公告)号：US20110256404A1
公开(公告)日：2011-10-20
申请号：US13122094
申请日：2009-09-30
申请人： Eric Tulsky , Eric Welch , Bruce Branchaud , Roman Rozhkov
发明人： Eric Tulsky , Eric Welch , Bruce Branchaud , Roman Rozhkov
CPC分类号： C09K11/025 , C09K11/883 , Y10T428/2998
摘要： Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.
摘要翻译： 描述了具有包括纳米晶体结合中心和一个或多个共价连接的官能团或反应性官能团的多功能表面配体的有机表面层的涂覆的荧光半导体纳米颗粒以及具有有机表面层或多层结构的水分散性纳米颗粒， 功能性表面配体和用于制备和使用这种包被的纳米颗粒的方法。
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公开(公告)号：US20070232579A1
公开(公告)日：2007-10-04
申请号：US11568377
申请日：2005-04-26
申请人： Bruce Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing Chen , Bruce Branchaud , Bugene Chen , Bruce Branchaud
发明人： Bruce Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing Chen , Bruce Branchaud , Bugene Chen , Bruce Branchaud
IPC分类号： A61K31/575 , A61K31/20 , A61P17/00 , A61P19/02 , A61P43/00 , A61P9/00 , C07B43/02 , C07C229/00 , C07J9/00 , C12N5/08 , C12N5/10 , C12N9/99 , G01N33/92
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译： 本文描述了硝化脂质和制备和使用硝化脂质的方法。
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6.发明申请公开(公告)号：US20130287689A1
公开(公告)日：2013-10-31
申请号：US13881672
申请日：2011-11-01
申请人： Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli , Lai-Qiang Ying , Bruce Branchaud
发明人： Hee Chol Kang , Kyle Gee , Bhaskar Mandavilli , Lai-Qiang Ying , Bruce Branchaud
CPC分类号： G01N21/6486 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
摘要： The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.
摘要翻译： 本发明涉及通过常规荧光显微镜，荧光光谱，流式细胞术和/或高含量成像检测活性氧（ROS）的化合物，组合物，方法和试剂盒。 本文公开的化合物是新的还原染料，包括基于Cy的氢化花青染料和Cy-基氘异氰染料，其染料是用于检测ROS的探针和测量体外和/或体内细胞中的氧化应激。 本文还描述了用于制备用于所公开的组合物，方法和试剂盒的新型还原染料即ROS探针的方法。
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公开(公告)号：US09790167B2
公开(公告)日：2017-10-17
申请号：US13611112
申请日：2012-09-12
申请人： Bruce A. Freeman , Bruce Branchaud
发明人： Bruce A. Freeman , Bruce Branchaud
IPC分类号： C07C205/50
CPC分类号： C07C205/50
摘要： Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
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公开(公告)号：US20130210917A1
公开(公告)日：2013-08-15
申请号：US13646985
申请日：2012-10-08
申请人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
发明人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
IPC分类号： C07C205/03
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译： 本文描述了硝化脂质和制备和使用硝化脂质的方法。
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公开(公告)号：US08309526B2
公开(公告)日：2012-11-13
申请号：US12797460
申请日：2010-06-09
申请人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
发明人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
IPC分类号： A61K31/70
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译： 本文描述了硝化脂质和制备和使用硝化脂质的方法。
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公开(公告)号：US20100331268A1
公开(公告)日：2010-12-30
申请号：US12797460
申请日：2010-06-09
申请人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
发明人： Bruce A. Freeman , Francisco Schopfer , Valerie O'Donnell , Paul Baker , Yuqing E. Chen , Bruce Branchaud
IPC分类号： A61K31/7028 , C07C57/12 , C07J1/00 , A61K31/201 , A61K31/56 , C07H15/06 , C07F9/09 , A61K31/683 , A61P9/00 , A61P3/10 , A61P13/12 , A61P17/06 , A61P25/00 , A61P29/00 , C12N5/071 , C12N5/0787 , C12N9/12
CPC分类号： A61K31/201 , A61K31/202 , A61K31/21 , A61K31/575 , A61K45/06 , C07B43/02 , C07C205/03 , C07C205/50 , C07C205/51
摘要： Described herein are nitrated lipids and methods of making and using the nitrated lipids.
摘要翻译： 本文描述了硝化脂质和制备和使用硝化脂质的方法。
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