专利检索 ap:("Erich L. Grimm" OR "Yves Ducharme" OR "Richard Frenette" OR "Richard Friesen" OR "Marc Gagnon" OR "Helene Juteau" OR "Sebastien Laliberte" OR "Bruce MacKay" OR "Yves Gareau") AND inv:"Richard Frenette" 第 1 页

1.

发明授权
Pharmaceutical phenylquinoline and chromen-2-one triazole compounds 失效
标题翻译：药用苯基喹啉和色烯-2-酮三唑化合物

公开(公告)号：US07960409B2

公开(公告)日：2011-06-14

申请号：US12012246

申请日：2008-02-01

申请人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau

发明人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau

IPC分类号： A61K31/47 , A61K31/4192 , C07D487/04 , C07D401/06

CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14

摘要： The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

摘要翻译： 本发明提供了作为白三烯生物合成抑制剂的式I化合物。式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

2.

发明申请
Novel pharmaceutical compounds 失效
标题翻译：新型药物化合物

公开(公告)号：US20080188521A1

公开(公告)日：2008-08-07

申请号：US12012246

申请日：2008-02-01

申请人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau

发明人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau

IPC分类号： A61K31/4709 , C07D403/08 , A61K31/4192 , A61P9/10 , A61P11/06 , A61P29/00 , C07D401/08

CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14

摘要： The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

摘要翻译： 本发明提供了作为白三烯生物合成抑制剂的式I化合物。式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

3.

发明申请
Use of phosphodiesterase-4 inhibitors as enhancers of cognition 审中-公开
标题翻译：使用磷酸二酯酶-4抑制剂作为认知的增强剂

公开(公告)号：US20060040981A1

公开(公告)日：2006-02-23

申请号：US10536250

申请日：2003-11-19

申请人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier

发明人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier

IPC分类号： A61K31/4709 , A61K31/47

CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47

摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.

摘要翻译： 本发明涉及增强健康受试者的认知的方法，其包括施用安全认知增加量的磷酸二酯酶-4抑制剂。特别地，本发明涉及增加健康受试者的记忆，学习，保留，召回，意识和判断的方法，包括施用安全有效量的磷酸二酯酶-4抑制剂。

4.

发明申请
2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles 审中-公开
标题翻译： 2-（苯基或杂环）-1H-菲并[9,10-D]咪唑

公开(公告)号：US20090286772A1

公开(公告)日：2009-11-19

申请号：US12224275

申请日：2007-02-22

申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel

发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Pierre Hamel

IPC分类号： A61K31/4184 , C07D235/04 , C07D401/04 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/5377 , A61K31/541 , A61P25/00 , A61P19/00

CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04

摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括式（I）的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

5.

发明申请
2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译：作为mPGES-1抑制剂的2-（苯基或杂环）-1H-苯并[9,10-d]咪唑

公开(公告)号：US20070208017A1

公开(公告)日：2007-09-06

申请号：US11374288

申请日：2005-11-23

申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4245 , A61K31/4188 , C07D403/14 , C07D413/14

CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06

摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

6.

发明授权
2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂

公开(公告)号：US07943649B2

公开(公告)日：2011-05-17

申请号：US12288947

申请日：2008-10-24

申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

IPC分类号： A61K31/4184 , A61K31/5377 , C07D235/02 , C07D413/14

CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06

摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

7.

发明申请
2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂

公开(公告)号：US20090075998A1

公开(公告)日：2009-03-19

申请号：US12288947

申请日：2008-10-24

申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4439 , A61K31/4245 , A61K31/501 , A61K31/41

CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06

摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

8.

发明授权
2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译： 2-（苯基或杂环）-1H-吡唑并[9,10-d]咪唑，为mPGES-1抑制剂

公开(公告)号：US07442716B2

公开(公告)日：2008-10-28

申请号：US11374288

申请日：2005-11-23

申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu

IPC分类号： A61K31/4184 , A61K31/5377 , C07D235/02 , C07D413/14

CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06

摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

摘要翻译： 本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。