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1.发明申请公开(公告)号：US20120302737A1
公开(公告)日：2012-11-29
申请号：US13496696
申请日：2010-09-16
CPC分类号： C07K16/468 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/51 , C07K2317/53 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/73
摘要： The invention provides engineered protein complexes constructed using a coiled coil and/or a tether and methods for making, using, and purifying such complexes, such as multispecific antibodies or other multispecific Fc containing complexes.
摘要翻译： 本发明提供了使用卷曲螺旋和/或系链构建的工程改造的蛋白质复合物，以及用于制备，使用和纯化这些复合物如多特异性抗体或其它多特异性Fc复合物的方法。
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公开(公告)号：US08278099B1
公开(公告)日：2012-10-02
申请号：US08433767
申请日：1995-05-03
CPC分类号： C07K14/524 , C07K2319/00 , C07K2319/30
摘要： Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
摘要翻译： 公开了分离的血小板生成素（TPO），编码TPO的分离的DNA，以及制备和纯化TPO的重组或合成方法。 显示各种形式的TPO影响血细胞，特别是巨核细胞和巨核细胞祖细胞的复制，分化或成熟。 因此，这些化合物可用于治疗血小板减少症。
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3.发明授权mpl ligand (thrombopoietin), active fragments thereof, and fusion proteins and compositions comprising mpl ligand and other cytokines 失效mpl配体（血小板生成素），其活性片段和融合蛋白以及包含mpl配体和其它细胞因子的组合物公开(公告)号：US08193323B1
公开(公告)日：2012-06-05
申请号：US08423194
申请日：1995-04-18
CPC分类号： C07K14/524 , A61K38/00
摘要： Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocytes and megakaryocyte progenitor cells. Accordingly, these compounds may be used for treatment of thrombocytopenia.
摘要翻译： 公开了分离的mpl配体，编码mpl配体的分离的DNA，以及制备mpl配体的重组或合成方法。 显示这些mpl配体影响血液细胞，特别是巨核细胞和巨核细胞祖细胞的复制，分化或成熟。 因此，这些化合物可用于治疗血小板减少症。
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公开(公告)号：US20100145027A1
公开(公告)日：2010-06-10
申请号：US12702086
申请日：2010-02-08
申请人： Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
发明人： Avi J. Ashkenazi , Dan L. Eaton , Audrey Goddard , Austin L. Gurney , William I. Wood , Thomas D. Wu
IPC分类号： C07K16/18 , C07K14/435
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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5.发明申请公开(公告)号：US20090068178A1
公开(公告)日：2009-03-12
申请号：US12023811
申请日：2008-01-31
申请人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Junutula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
发明人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Junutula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/06 , C12N9/96 , A61K39/44 , C12Q1/68 , A61K31/7088 , G01N33/574 , C12N5/08 , C12N5/02 , C07K14/00 , C07K16/00 , A61P35/04 , C12P21/08 , A61K38/16
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US07294695B2
公开(公告)日：2007-11-13
申请号：US10243189
申请日：2002-09-12
申请人： Kevin P. Baker , Dan L. Eaton , Ellen Filvaroff , Audrey Goddard , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean Philippe Stephan , Colin K. Watanabe , William I. Wood , Zemin Zhang , Sherman Fong
发明人： Kevin P. Baker , Dan L. Eaton , Ellen Filvaroff , Audrey Goddard , J. Christopher Grimaldi , Austin L. Gurney , Victoria Smith , Jean Philippe Stephan , Colin K. Watanabe , William I. Wood , Zemin Zhang , Sherman Fong
IPC分类号： C07K14/00
CPC分类号： C07H21/04 , C07K14/435 , C12N5/06 , C12N9/00 , C12P21/02
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07230082B2
公开(公告)日：2007-06-12
申请号：US10063602
申请日：2002-05-03
申请人： Dan L. Eaton , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Colin K. Watanabe , William I. Wood
发明人： Dan L. Eaton , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Colin K. Watanabe , William I. Wood
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07094567B2
公开(公告)日：2006-08-22
申请号：US09906815
申请日：2001-07-16
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07071304B2
公开(公告)日：2006-07-04
申请号：US10006117
申请日：2001-12-06
IPC分类号： C07K1/00
CPC分类号： C07K14/435 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US06974689B1
公开(公告)日：2005-12-13
申请号：US09906679
申请日：2001-07-16
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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