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公开(公告)号：US20190211018A1
公开(公告)日：2019-07-11
申请号：US16099136
申请日：2017-05-05
申请人： Erin M. DUFFY , Ashoke BHATTACHARJEE , Zoltan F. KANYO , Joseph A. IP-POLITO , Melinta Therapeutics, Inc.
IPC分类号： C07D487/04 , A61P31/04
CPC分类号： C07D487/04 , A61P31/04
摘要： The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US08202843B2
公开(公告)日：2012-06-19
申请号：US10590782
申请日：2005-02-25
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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5.发明授权公开(公告)号：US07335753B2
公开(公告)日：2008-02-26
申请号：US11359820
申请日：2006-02-21
申请人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： A61K31/7052 , A61K31/7048 , A61K31/4709 , A61K31/4176 , A61K31/4192 , A61K31/422 , C07H17/08 , C07D249/04 , C07D261/04 , C07D403/04 , C07D215/06
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.
摘要翻译： 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。
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6.发明授权公开(公告)号：US07091196B2
公开(公告)日：2006-08-15
申请号：US10671326
申请日：2003-09-25
申请人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： C07D267/00 , C07D413/14 , A61K31/5377
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents, and/or prokinetic (gastrointestinal modulatory) agents, having the formula: or pharmaceutically acceptable salts, esters, or prodrugs thereof.
摘要翻译： 本发明提供了可用作抗感染剂和/或抗增殖剂的化合物家族，例如化学治疗剂，抗真菌剂，抗细菌剂，抗寄生虫剂，抗病毒剂和/或 具有下式的抗炎剂和/或促动力（胃肠调节剂）或其药学上可接受的盐，酯或前药。
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公开(公告)号：US20150158901A1
公开(公告)日：2015-06-11
申请号：US14327452
申请日：2014-07-09
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20190194205A1
公开(公告)日：2019-06-27
申请号：US16099047
申请日：2017-05-05
IPC分类号： C07D487/04 , A61P31/04
摘要： The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I) or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
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公开(公告)号：US20180066007A1
公开(公告)日：2018-03-08
申请号：US15493344
申请日：2017-04-21
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
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