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公开(公告)号：US08470985B2
公开(公告)日：2013-06-25
申请号：US11990833
申请日：2006-08-24
IPC分类号： C07H17/08
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory, and prokinetic agents. These compounds are represented by the following formula (I): wherein R1, R2, ect. Are defined in claim 1.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地说，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。 这些化合物由下式（I）表示：其中R1，R2等。 在权利要求1中定义。
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公开(公告)号：US09193731B2
公开(公告)日：2015-11-24
申请号：US13501825
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号： C07D487/04 , A61P31/04 , C07D491/048 , C07D519/00
CPC分类号： C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
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公开(公告)号：US20130065845A1
公开(公告)日：2013-03-14
申请号：US13616962
申请日：2012-09-14
IPC分类号： A61K31/7042 , C07H17/08 , A61K31/706 , A61K31/7056 , A61P31/00 , A61P1/00 , A61P35/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P31/12 , A61P1/10 , C07H17/00 , A61P29/00
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120220566A1
公开(公告)日：2012-08-30
申请号：US13501825
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号： A61K31/551 , A61K31/522 , A61P31/04 , A61K31/541 , A61K31/496 , A61P31/00 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US20190211018A1
公开(公告)日：2019-07-11
申请号：US16099136
申请日：2017-05-05
申请人： Erin M. DUFFY , Ashoke BHATTACHARJEE , Zoltan F. KANYO , Joseph A. IP-POLITO , Melinta Therapeutics, Inc.
IPC分类号： C07D487/04 , A61P31/04
CPC分类号： C07D487/04 , A61P31/04
摘要： The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
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公开(公告)号：US09221827B2
公开(公告)日：2015-12-29
申请号：US14112027
申请日：2012-04-11
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Shili Chen , Zoltan F. Kanyo , Matthew H. Scheideman , Yuanqing Tang
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Shili Chen , Zoltan F. Kanyo , Matthew H. Scheideman , Yuanqing Tang
IPC分类号： A61K31/519 , C07D487/04 , C07D403/12 , C07D401/14 , C07D239/36
CPC分类号： C07D487/04 , C07D239/36 , C07D401/14 , C07D403/12
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US20140163049A1
公开(公告)日：2014-06-12
申请号：US14112027
申请日：2012-04-11
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Shili Chen , Zoltan F. Kanyo , Matthew H. Scheideman , Yuanqing Tang
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Shili Chen , Zoltan F. Kanyo , Matthew H. Scheideman , Yuanqing Tang
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D239/36 , C07D401/14 , C07D403/12
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US20100016956A1
公开(公告)日：2010-01-21
申请号：US11990883
申请日：2006-08-24
IPC分类号： A61F2/06 , C07H17/08 , C07H17/00 , A61K31/7048 , A61K31/7052 , A61P31/00
摘要： The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The compounds have the following structure: wherein T is the macrocyclic part.
摘要翻译： 本发明提供可用作治疗剂的三唑大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。 该化合物具有以下结构：其中T是大环部分。
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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