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公开(公告)号：US20140155381A1
公开(公告)日：2014-06-05
申请号：US14235512
申请日：2012-07-27
申请人： Erkan Baloglu , Gary J. Bohnert , Shomir Ghosh , Mercedes Lobera , Darby R. Schmidt , Leonard Sung
发明人： Erkan Baloglu , Gary J. Bohnert , Shomir Ghosh , Mercedes Lobera , Darby R. Schmidt , Leonard Sung
IPC分类号： C07D413/14 , C07D407/06 , C07D407/14 , C07D413/06
CPC分类号： C07D413/14 , C07D405/06 , C07D405/14 , C07D407/06 , C07D407/14 , C07D413/06 , C07D491/048
摘要： The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
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2.发明申请SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE 审中-公开替代苯扎唑及其作为RAF激酶抑制剂的方法公开(公告)号：US20120288501A1
公开(公告)日：2012-11-15
申请号：US13556907
申请日：2012-07-24
申请人： Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , C07D417/14 , A61K31/5377 , A61K33/24 , A61K31/513 , A61P35/00 , A61K31/506 , A61K31/664 , A61K31/7068 , A61K31/519 , A61K31/4745 , C07D417/12 , A61K39/395
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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3.发明授权Substituted benz-azoles and methods of their use as inhibitors of RAF kinase 失效取代的苯并唑及其作为RAF激酶抑制剂的方法公开(公告)号：US08614330B2
公开(公告)日：2013-12-24
申请号：US12723483
申请日：2010-03-12
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , C07D417/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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4.发明申请SUBSTITUTED BENZ-AZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE 失效取代的苯甲腈及其作为RAF激酶抑制剂的方法公开(公告)号：US20100196368A1
公开(公告)日：2010-08-05
申请号：US12723483
申请日：2010-03-12
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , C07D401/12 , C07D405/14 , C07D413/14 , A61K31/5377 , A61K31/635 , C07D417/12 , C07D417/14 , C07D409/14 , C07D401/14 , A61K31/496 , A61K31/4725 , A61K31/444 , A61K31/4545 , A61K31/55 , C07D413/12 , C07D453/02 , A61K31/439 , A61K31/551 , A61K31/506 , C07D403/12 , A61K31/4184 , C07D235/30 , A61K31/4745 , A61K31/7068 , A61K31/519 , A61K33/24 , A61K31/66 , A61K31/704 , A61K39/395 , A61P35/00
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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5.发明授权Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US07728010B2
公开(公告)日：2010-06-01
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J Poon , Savithri Ramurthy , Paul A Renhowe , Cynthia M Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J Poon , Savithri Ramurthy , Paul A Renhowe , Cynthia M Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/423 , A61K31/4439 , C07D263/58 , C07D413/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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公开(公告)号：US08440652B2
公开(公告)日：2013-05-14
申请号：US13410407
申请日：2012-03-02
申请人： David John Augeri , Jeffrey Thomas Bagdanoff , Simon David Peter Baugh , Marianne Carlsen , Kenneth Gordon Carson , John Anthony Gilleran , Wei He , Tamas Oravecz , Konstantin Salojin , Leonard Sung
发明人： David John Augeri , Jeffrey Thomas Bagdanoff , Simon David Peter Baugh , Marianne Carlsen , Kenneth Gordon Carson , John Anthony Gilleran , Wei He , Tamas Oravecz , Konstantin Salojin , Leonard Sung
IPC分类号： C07D401/14 , C07D495/04 , A61K31/4418 , A61K31/444
CPC分类号： C07D401/04 , A61K31/4365 , A61K31/4418 , A61K31/444 , A61K31/4725 , A61K31/497 , A61K31/55 , A61K31/5513 , A61K31/553 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders. Particular compounds are of the formula:
摘要翻译： 公开了用于抑制哺乳动物Ste20样激酶1（MST1）的化合物及其组合物及其用于治疗，控制或预防炎性或自身免疫性疾病或病症的方法。 具体化合物具有下式：
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7.发明授权Substituted benzazoles and methods of their use as inhibitors of raf kinase 失效取代的苯并唑及其作为raf激酶抑制剂的方法公开(公告)号：US08299108B2
公开(公告)日：2012-10-30
申请号：US10675927
申请日：2003-09-29
申请人： Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Barry Haskell Levine , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/415 , C07D401/00
CPC分类号： C04B35/632 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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8.发明申请Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US20070299039A1
公开(公告)日：2007-12-27
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K31/665 , A61P35/00 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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公开(公告)号：US20120225857A1
公开(公告)日：2012-09-06
申请号：US13410407
申请日：2012-03-02
申请人： David John Augeri , Jeffrey Thomas Bagdanoff , Simon David Peter Baugh , Marianne Carlsen , Kenneth Gordon Carson , John Anthony Gilleran , Wei He , Tamas Oravecz , Konstantin Salojin , Leonard Sung
发明人： David John Augeri , Jeffrey Thomas Bagdanoff , Simon David Peter Baugh , Marianne Carlsen , Kenneth Gordon Carson , John Anthony Gilleran , Wei He , Tamas Oravecz , Konstantin Salojin , Leonard Sung
IPC分类号： A61K31/4725 , C07D409/14 , C07D213/73 , C07D401/04 , C07D417/14 , C07D401/14 , C07D495/04 , C07D413/10 , A61K31/4418 , A61K31/444 , A61K31/497 , A61K31/5513 , A61K31/4365 , A61K31/55 , A61K31/553 , A61P29/00 , A61P37/00 , A61P17/00 , A61P1/00 , A61P25/00 , A61P21/04 , A61P17/06 , A61P19/02 , A61P3/10 , A61P1/04 , C07D401/10
CPC分类号： C07D401/04 , A61K31/4365 , A61K31/4418 , A61K31/444 , A61K31/4725 , A61K31/497 , A61K31/55 , A61K31/5513 , A61K31/553 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D495/04
摘要： Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.
摘要翻译： 公开了用于抑制哺乳动物Ste20样激酶1（MST1）的化合物及其组合物及其用于治疗，控制或预防炎性或自身免疫疾病或病症的方法。
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10.发明授权Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US07071216B2
公开(公告)日：2006-07-04
申请号：US10405945
申请日：2003-03-31
申请人： Paul A. Renhowe , Savithri Ramurthy , Payman Amiri , Barry Haskell Levine , Daniel J. Poon , Sharadha Subramanian , Leonard Sung , Wendy Fantl , Teresa Hansen , Christopher McBride , Cynthia M. Shafer
发明人： Paul A. Renhowe , Savithri Ramurthy , Payman Amiri , Barry Haskell Levine , Daniel J. Poon , Sharadha Subramanian , Leonard Sung , Wendy Fantl , Teresa Hansen , Christopher McBride , Cynthia M. Shafer
IPC分类号： A61K31/4184 , A61K31/4439 , C07D235/30 , C07D401/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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