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1.发明申请Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US20070299039A1
公开(公告)日：2007-12-27
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K31/665 , A61P35/00 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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2.发明申请Substituted benzazoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其作为Raf激酶抑制剂的方法公开(公告)号：US20050192287A1
公开(公告)日：2005-09-01
申请号：US10967089
申请日：2004-10-15
申请人： Abran Costales , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Joelle Verhagen
发明人： Abran Costales , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Joelle Verhagen
IPC分类号： A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C04B35/632 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯唑化合物，抑制人或动物受试者中的Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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3.发明授权Substituted benz-azoles and methods of their use as inhibitors of RAF kinase 失效取代的苯并唑及其作为RAF激酶抑制剂的方法公开(公告)号：US08614330B2
公开(公告)日：2013-12-24
申请号：US12723483
申请日：2010-03-12
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , C07D417/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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4.发明申请SUBSTITUTED BENZ-AZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE 失效取代的苯甲腈及其作为RAF激酶抑制剂的方法公开(公告)号：US20100196368A1
公开(公告)日：2010-08-05
申请号：US12723483
申请日：2010-03-12
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , C07D401/12 , C07D405/14 , C07D413/14 , A61K31/5377 , A61K31/635 , C07D417/12 , C07D417/14 , C07D409/14 , C07D401/14 , A61K31/496 , A61K31/4725 , A61K31/444 , A61K31/4545 , A61K31/55 , C07D413/12 , C07D453/02 , A61K31/439 , A61K31/551 , A61K31/506 , C07D403/12 , A61K31/4184 , C07D235/30 , A61K31/4745 , A61K31/7068 , A61K31/519 , A61K33/24 , A61K31/66 , A61K31/704 , A61K39/395 , A61P35/00
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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5.发明授权Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US07728010B2
公开(公告)日：2010-06-01
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J Poon , Savithri Ramurthy , Paul A Renhowe , Cynthia M Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Haskell Levine , Christopher McBride , Daniel J Poon , Savithri Ramurthy , Paul A Renhowe , Cynthia M Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/423 , A61K31/4439 , C07D263/58 , C07D413/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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6.发明授权Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其用作Raf激酶抑制剂的方法公开(公告)号：US07071216B2
公开(公告)日：2006-07-04
申请号：US10405945
申请日：2003-03-31
申请人： Paul A. Renhowe , Savithri Ramurthy , Payman Amiri , Barry Haskell Levine , Daniel J. Poon , Sharadha Subramanian , Leonard Sung , Wendy Fantl , Teresa Hansen , Christopher McBride , Cynthia M. Shafer
发明人： Paul A. Renhowe , Savithri Ramurthy , Payman Amiri , Barry Haskell Levine , Daniel J. Poon , Sharadha Subramanian , Leonard Sung , Wendy Fantl , Teresa Hansen , Christopher McBride , Cynthia M. Shafer
IPC分类号： A61K31/4184 , A61K31/4439 , C07D235/30 , C07D401/12
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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7.发明申请SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE 审中-公开替代苯扎唑及其作为RAF激酶抑制剂的方法公开(公告)号：US20130224195A1
公开(公告)日：2013-08-29
申请号：US13856225
申请日：2013-04-03
申请人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
发明人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
IPC分类号： C07D401/12 , C07D405/12 , C07D401/14 , A61K31/4545 , A61K31/5377 , A61K45/06 , A61K31/444 , C07D417/12 , C07D417/14 , C07D413/14 , A61K31/551 , A61K31/4439 , A61K31/496
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C04B35/632 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯唑化合物，抑制人或动物受试者中的Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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8.发明授权Substituted benzazoles and methods of their use as inhibitors of Raf kinase 失效取代的苯并唑及其作为Raf激酶抑制剂的方法公开(公告)号：US07423150B2
公开(公告)日：2008-09-09
申请号：US10967089
申请日：2004-10-15
申请人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
发明人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
IPC分类号： C07D401/00 , C07D233/00 , C07D233/02
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C04B35/632 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯唑化合物，抑制人或动物受试者中的Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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9.发明授权Substituted benzazoles and methods of their use as inhibitors of RAF Kinase 失效取代的苯并唑及其作为RAF激酶抑制剂的方法公开(公告)号：US08415382B2
公开(公告)日：2013-04-09
申请号：US12205028
申请日：2008-09-05
申请人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
发明人： Abran Costales , Teresa Hansen , Barry H. Levine , Christopher McBride , Daniel J. Poon , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Sharadha Subramanian , Joelle Verhagen
IPC分类号： A61K31/44
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C04B35/632 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译： 提供了新的取代的苯唑化合物，抑制人或动物受试者中的Raf激酶活性的组合物和方法。 新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。
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