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公开(公告)号:US5840722A
公开(公告)日:1998-11-24
申请号:US718377
申请日:1996-09-30
申请人: Ernst Baumann , Uwe Josef Vogelbacher , Joachim Rheinheimer , Dagmar Klinge , Hartmut Riechers , Burkhard Kroger , Siegfried Bialojan , Claus Bollschweiler , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Ernst Baumann , Uwe Josef Vogelbacher , Joachim Rheinheimer , Dagmar Klinge , Hartmut Riechers , Burkhard Kroger , Siegfried Bialojan , Claus Bollschweiler , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D251/26 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A01N43/66
CPC分类号: A61K31/505 , A61K31/506 , A61K31/53
摘要: A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I ##STR1##
摘要翻译: PCT No.PCT / EP95 / 01099 Sec。 371日期1996年9月30日 102(e)1996年9月30日PCT PCT 1995年3月23日PCT公布。 第WO95 / 26716号公报 日期1995年10月12日一种通过向患者施用式I化合物来抑制内皮素受体的方法
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公开(公告)号:US07109205B2
公开(公告)日:2006-09-19
申请号:US10602275
申请日:2003-06-24
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D239/02 , A61K31/505
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R–R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
摘要翻译: 其中R-R 6,X,Y和Z具有说明书中所述含义及其制备的羧酸衍生物。 新型化合物适用于控制疾病。
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公开(公告)号:US06197958B1
公开(公告)日:2001-03-06
申请号:US09309770
申请日:1999-05-11
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D23726
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R—R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
摘要翻译: 其中R-R6,X,Y和Z的羧酸衍生物具有说明书中所述的含义及其制备。 新型化合物适用于控制疾病。
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公开(公告)号:US07601730B2
公开(公告)日:2009-10-13
申请号:US11502293
申请日:2006-08-10
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: A61P7/02
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R—R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号:USRE42462E1
公开(公告)日:2011-06-14
申请号:US12481594
申请日:1995-10-07
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D239/60 , C07D239/96 , C07D251/30 , C07D403/12
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号:US20100076188A1
公开(公告)日:2010-03-25
申请号:US12542050
申请日:2009-08-17
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Müller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D239/70 , C07D239/02
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R—R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
摘要翻译: 其中R-R6,X,Y和Z具有说明书中所述含义的羧酸衍生物及其制备。 新型化合物适用于控制疾病。
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公开(公告)号:US07582647B2
公开(公告)日:2009-09-01
申请号:US11789630
申请日:2007-04-25
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: A61P9/12
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R—R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
摘要翻译: 其中R-R6,X,Y和Z具有说明书中所述含义的羧酸衍生物及其制备。 新型化合物适用于控制疾病。
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公开(公告)号:US5969134A
公开(公告)日:1999-10-19
申请号:US184152
申请日:1998-11-02
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D251/18 , C07D251/00 , C07D251/02 , C07D403/02
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives ##STR1## where R-R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号:USRE42477E1
公开(公告)日:2011-06-21
申请号:US12481598
申请日:1997-03-27
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D239/60 , C07D239/96 , C07D251/30 , C07D403/12
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
摘要翻译: 其中R-R6,X,Y和Z具有说明书中所述含义的羧酸衍生物及其制备。 新型化合物适用于控制疾病。
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公开(公告)号:US07863445B2
公开(公告)日:2011-01-04
申请号:US12542050
申请日:2009-08-17
申请人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人: Hartmut Riechers , Dagmar Klinge , Wilhelm Amberg , Andreas Kling , Stefan Muller , Ernst Baumann , Joachim Rheinheimer , Uwe Josef Vogelbacher , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号: C07D239/02
CPC分类号: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
摘要: Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
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