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公开(公告)号：US5840722A
公开(公告)日：1998-11-24
申请号：US718377
申请日：1996-09-30
申请人： Ernst Baumann , Uwe Josef Vogelbacher , Joachim Rheinheimer , Dagmar Klinge , Hartmut Riechers , Burkhard Kroger , Siegfried Bialojan , Claus Bollschweiler , Wolfgang Wernet , Liliane Unger , Manfred Raschack
发明人： Ernst Baumann , Uwe Josef Vogelbacher , Joachim Rheinheimer , Dagmar Klinge , Hartmut Riechers , Burkhard Kroger , Siegfried Bialojan , Claus Bollschweiler , Wolfgang Wernet , Liliane Unger , Manfred Raschack
IPC分类号： C07D251/26 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A01N43/66
CPC分类号： A61K31/505 , A61K31/506 , A61K31/53
摘要： A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I ##STR1##
摘要翻译： PCT No.PCT / EP95 / 01099 Sec。 371日期1996年9月30日 102（e）1996年9月30日PCT PCT 1995年3月23日PCT公布。 第WO95 / 26716号公报 日期1995年10月12日一种通过向患者施用式I化合物来抑制内皮素受体的方法
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2.发明申请Method of modifying the genome of gram-positive bacteria by means of a novel conditionally negative dominant marker gene 审中-公开通过新型条件阴性显性标记基因修饰革兰氏阳性细菌基因组的方法公开(公告)号：US20100240131A1
公开(公告)日：2010-09-23
申请号：US11476404
申请日：2006-06-28
CPC分类号： C12N9/1055 , C12N15/77
摘要： The invention relates to a novel method for modifying the genome of Gram-positive bacteria, to these bacteria and to novel vectors. The invention particularly relates to a method for modifying corynebacteria or brevibacteria with the aid of a novel marker gene which has a conditionally negatively dominant action in the bacteria.
摘要翻译： 本发明涉及一种用于修饰革兰氏阳性菌，这些细菌和新颖载体的基因组的新方法。 本发明特别涉及一种借助于在细菌中具有有条件负向主导作用的新型标记基因来修饰棒状杆菌或短纤维细菌的方法。
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公开(公告)号：US20090029356A1
公开(公告)日：2009-01-29
申请号：US11699982
申请日：2007-01-29
CPC分类号： C07K14/34 , C07H21/02 , C07H21/04 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/222 , C12P13/225 , C12P13/227 , C12P13/24
摘要： Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCP genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MCP蛋白质的分离的核酸分子，命名为MCP核酸分子。 本发明还提供反义核酸分子，含有MCP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的MCP蛋白，突变的MCP蛋白，融合蛋白，抗原肽和用于根据该生物体中MCP基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。
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公开(公告)号：US20080274516A1
公开(公告)日：2008-11-06
申请号：US10583191
申请日：2004-12-16
CPC分类号： C12N15/77
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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5.发明申请Methods for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum 审中-公开通过发酵谷氨酸棒杆菌制备赖氨酸的方法公开(公告)号：US20080160585A1
公开(公告)日：2008-07-03
申请号：US12021081
申请日：2008-01-28
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译： 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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6.发明申请Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding 审中-公开编码参与遗传稳定性，基因表达和蛋白质分泌和折叠的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20080096211A1
公开(公告)日：2008-04-24
申请号：US11890181
申请日：2007-08-03
IPC分类号： C12P21/04 , C07K14/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12P13/04 , C12P13/06 , C12P13/08 , C12P7/64 , G01N33/53 , C12Q1/68 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12P13/22 , C12P19/20 , C12P19/38
CPC分类号： C12P13/04 , G01N33/56911 , G01N2333/34 , G01N2500/00
摘要： Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SES proteins, mutated SES proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SES genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SES蛋白的分离的核酸分子，命名为SES核酸分子。 本发明还提供反义核酸分子，含有SES核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于该生物体中SES基因的遗传工程的分离的SES蛋白，突变的SES蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌生产所需化合物的方法。
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公开(公告)号：US20070269871A1
公开(公告)日：2007-11-22
申请号：US11632740
申请日：2005-07-16
摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。
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8.发明申请Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding 审中-公开编码参与遗传稳定性，基因表达和蛋白质分泌和折叠的蛋白质的谷氨酸棒杆菌基因公开(公告)号：US20070161091A1
公开(公告)日：2007-07-12
申请号：US11041504
申请日：2005-01-21
CPC分类号： C07K14/34 , C12N9/0069 , C12P13/04
摘要： Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated SES proteins, mutated SES proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of SES genes in this organism.
摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型SES蛋白的分离的核酸分子，命名为SES核酸分子。 本发明还提供反义核酸分子，含有SES核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了基于该生物体中SES基因的遗传工程的分离的SES蛋白，突变的SES蛋白，融合蛋白，抗原肽和用于从谷氨酸棒球菌生产所需化合物的方法。
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公开(公告)号：US20070143930A1
公开(公告)日：2007-06-28
申请号：US11682924
申请日：2007-03-07
申请人： Hans-Georg LEMAIRE , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
发明人： Hans-Georg LEMAIRE , Tilman Taeger , Gunther Pabst , Philippe Lamalle , Michael Breuer , Burkhard Kroger , Thomas Subkowski
IPC分类号： C14C1/06
CPC分类号： C14C1/065
摘要： Horny substances are removed from animal hides by a process wherein animal hides are treated in a liquor comprising from 0.05 to 5% by weight, based on the salted weight, of one or more compounds of the formula I or the corresponding alkali metal or alkaline earth metal or ammonium or phosphonium salts thereof, the variables being defined as follows: R1 is selected from hydrogen and C1-C12-alkyl, unsubstituted or substituted by one or more S—H or O—H groups; X1 to X4 are identical or different and are selected from hydrogen, C1-C4-alkyl, O—H, S—H and N—HR2, R2 is hydrogen or C1-C12-alkyl or a C1-C4-alkyl-C═O group, at least one of the radicals X1 to X4 being S—H, and, if R1 contains neither O—H nor S—H, at least one further radical from among X1 to X4 is selected from S—H, OH and NH—R2, and furthermore with at least one compound which catalyzes the hydrolysis of peptide bonds.
摘要翻译： 通过一种方法将动物皮肤从动物皮革中去除，其中动物皮由含有0.05至5重量％（以盐重计）的一种或多种式I化合物或相应的碱金属或碱土金属 金属或铵或鏻盐，变量定义如下：R 1选自氢和C 1 -C 12 - 烷基 未取代或被一个或多个SH或OH基取代; X 1至X 4相同或不同，并且选自氢，C 1 -C 4 - C 4 - 烷基 ，OH，SH和N-HR 2，R 2是氢或C 1 -C 12 - C 12 - 烷基 或C 1 -C 4 - 烷基-CO基团，基团X 1至X 4中的至少一个， SUP>为SH，并且如果R 1不包含OH或SH，则X 1至X 4中的至少一个其它基团为 选自SH，OH和NH-R 2，以及至少一种催化肽键水解的化合物。
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10.发明申请Gene variants coding for proteins from the metabolic pathway of fine chemicals 有权编码精细化学物质代谢途径蛋白质的基因变体公开(公告)号：US20070122887A1
公开(公告)日：2007-05-31
申请号：US10583404
申请日：2004-12-16
申请人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Haefner , Uwe Ruffer , Claudia Graef
发明人： Corinna Klopprogge , Oskar Zelder , Burkhard Kroger , Hartwig Schroder , Stefan Haefner , Uwe Ruffer , Claudia Graef
CPC分类号： C07K14/34
摘要： The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.
摘要翻译： 本发明涉及精细化学品的代谢途径的突变核酸和蛋白质，制备经遗传修饰的生物体生物体的方法，通过培养所述转基因生物体和所述转基因生物本身来制备精细化学品的方法。
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