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公开(公告)号：US20060121063A1
公开(公告)日：2006-06-08
申请号：US11256589
申请日：2005-10-21
申请人： Erwin Rogeen , Esben Friis , Nanna Soni , Henriette Draborg
发明人： Erwin Rogeen , Esben Friis , Nanna Soni , Henriette Draborg
IPC分类号： A61K39/35 , C07H21/04 , C12N5/06 , C07K14/435
CPC分类号： C07K14/43531 , A61K39/00
摘要： This invention concerns variants of group 2 mite polypeptides, wherein the polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of D64, V40, E53, S57, K82, G83, I97 of SEQ ID NO: 1 or 64, 40, 53, 57, 82, 83, 97 of the Der p 2 polypeptide or the positions G32, D59, L61, E62, A98 of SEQ ID NO: 2 or 32, 59, 61, 62, 98 of the Der f 2 polypeptide.
摘要翻译： 本发明涉及组2螨多肽的变体，其中变体的多肽在SEQ ID NO：1的D64，V40，E53，S57，K82，G83，I97的位置或对应位置包含一个或多个突变 或Der p2多肽的64,40,53,57,82,83,97或SEQ ID NO：2或32,59,66,62,98的位置G32，D59，L61，E62，A98或32 Der f 2多肽。
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公开(公告)号：US08512985B2
公开(公告)日：2013-08-20
申请号：US13357223
申请日：2012-01-24
CPC分类号： C12N9/6472 , C07K14/37 , C12N9/16 , C12N9/2437 , C12N9/6424 , C12N15/625
摘要： The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising the nuclei acid construct.
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公开(公告)号：US20110003364A1
公开(公告)日：2011-01-06
申请号：US12879410
申请日：2010-09-10
申请人： Allan Svendsen , Henriette Draborg
发明人： Allan Svendsen , Henriette Draborg
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/21062
摘要： The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.
摘要翻译： 本发明涉及用于产生亲本TY145脱落酶和亲本BPN'脱羧酶的变体的方法，并且与亲本TY145 / BPN'脱羧酶相比具有改变的性质的TY145和BPN'变体的方法。
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公开(公告)号：US20100021967A1
公开(公告)日：2010-01-28
申请号：US12445495
申请日：2007-10-23
申请人： Henriette Draborg
发明人： Henriette Draborg
CPC分类号： C12N15/80 , C07K2319/02 , C12N15/625 , C12N15/81
摘要： The present invention relates to a method for producing a polypeptide comprising using a variant alpha factor signal peptide having a substitution in position 9 resulting in a substitution of an A to either T, S, H, I, F, E, or G. The invention further relate to nucleic acid constructs comprising a first nucleotide sequence encoding the variant signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising said nuclei acid construct.
摘要翻译： 本发明涉及生产多肽的方法，其包括使用在位置9具有取代的变体α因子信号肽，导致A取代T，S，H，I，F，E或G。 本发明还涉及包含编码变体信号肽的第一核苷酸序列和编码第一核苷酸序列异源的多肽的第二核苷酸序列的核酸构建体。 此外，它还涉及包含所述核酸构建体的表达载体和宿主细胞。
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公开(公告)号：US07294499B2
公开(公告)日：2007-11-13
申请号：US10786850
申请日：2004-02-24
申请人： Allan Svendsen , Henriette Draborg
发明人： Allan Svendsen , Henriette Draborg
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/21062
摘要： The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.
摘要翻译： 本发明涉及用于产生亲本TY145脱落酶和亲本BPN'脱羧酶的变体的方法，并且与亲本TY145 / BPN'脱羧酶相比具有改变的性质的TY145和BPN'变体的方法。
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公开(公告)号：US20130344573A1
公开(公告)日：2013-12-26
申请号：US13968958
申请日：2013-08-16
CPC分类号： C12N9/6472 , C07K14/37 , C12N9/16 , C12N9/2437 , C12N9/6424 , C12N15/625
摘要： The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising the nuclei acid construct.
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公开(公告)号：US20090191590A1
公开(公告)日：2009-07-30
申请号：US12415174
申请日：2009-03-31
CPC分类号： C12N9/6472 , C07K14/37 , C12N9/16 , C12N9/2437 , C12N9/6424 , C12N15/625
摘要： The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising the nuclei acid construct.
摘要翻译： 本发明涉及包含使用信号肽的多肽的制备方法，其包含编码信号肽的第一核苷酸序列的核酸构建体和编码第一核苷酸序列异源的多肽的第二核苷酸序列。 此外，它还涉及包含核酸构建体的表达载体和宿主细胞。
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公开(公告)号：US20090148893A1
公开(公告)日：2009-06-11
申请号：US11928576
申请日：2007-10-30
申请人： Allan Svendsen , Henriette Draborg
发明人： Allan Svendsen , Henriette Draborg
CPC分类号： C12N9/54 , C11D3/386 , C12Y304/21062
摘要： The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to the parent TY145/BPN′ subtilase.
摘要翻译： 本发明涉及用于产生亲本TY145脱落酶和亲本BPN'脱羧酶的变体的方法，并且与亲本TY145 / BPN'脱羧酶相比具有改变的性质的TY145和BPN'变体的方法。
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公开(公告)号：US20060003414A1
公开(公告)日：2006-01-05
申请号：US11152811
申请日：2005-06-14
IPC分类号： C12P21/06 , C07H21/04 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/20 , C12N1/16 , C12N9/24 , C12N15/74
CPC分类号： C12N9/6472 , C07K14/37 , C12N9/16 , C12N9/2437 , C12N9/6424 , C12N15/625
摘要： The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to expression vectors and host cells comprising the nuclei acid construct.
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公开(公告)号：US09732310B2
公开(公告)日：2017-08-15
申请号：US12974519
申请日：2010-12-21
申请人： Henriette Draborg , Peter Kamp Hansen , Mads Eskelund Bjornvad , Mads Norregaard-Madsen , Mikael Mikkelsen
发明人： Henriette Draborg , Peter Kamp Hansen , Mads Eskelund Bjornvad , Mads Norregaard-Madsen , Mikael Mikkelsen
摘要： The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
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