公开(公告)号：US5595948A

公开(公告)日：1997-01-21

申请号：US491173

申请日：1995-06-16

申请人： Etsuji Kimura ,  Kenichi Yamaguchi ,  Fumihiko Ogino ,  Susumu Okabe

发明人： Etsuji Kimura ,  Kenichi Yamaguchi ,  Fumihiko Ogino ,  Susumu Okabe

IPC分类号： C04B35/66 ,  C04B38/00 ,  C04B35/03 ,  C04B35/04 ,  C04B35/043

CPC分类号： C04B38/00 ,  C04B35/66 ,  C04B2235/3206 ,  C04B2235/3232 ,  C04B2235/3234

摘要： A refractory is disclosed which contains integrally sintered magnesia particles forming the skeleton of the refractory and a mineral phase of magnesium orthotitanate (Mg.sub.2 TiO.sub.4) formed between the magnesia particles, thus giving an increased erosion resistance. Preferably, the refractory comprises coarse magnesia particles having an average particle diameter of at least 1 mm or a mixture of coarse magnesia particles having an average particle diameter of at least 1 mm and medium magnesia particles having an average particle diameter of 1 to 0.15 mm and 5 to 50 wt. % of magnesium orthotitanate intervening between the magnesia particles. The refractory not only has an excellent durability in a basic atmosphere, but also has a high strength because of combination of the coarse or medium magnesia particles so that it does not tend to deform and has a high durability against thermal shock.

摘要翻译： 公开了一种耐火材料，其包含形成耐火材料骨架的一体烧结氧化镁颗粒和在氧化镁颗粒之间形成的原钛酸镁（Mg2TiO4）的矿物相，从而提高耐侵蚀性。 优选地，耐火材料包括平均粒径为至少1mm的粗氧化镁颗粒或平均粒径为至少1mm的粗氧化镁颗粒和平均粒径为1至0.15mm的中等氧化镁颗粒的混合物，以及 5至50wt。 介于氧化镁颗粒之间的原钛酸镁的百分比。 该耐火材料不仅在碱性气氛中具有优异的耐久性，而且由于粗，中等氧化镁颗粒的组合而具有高强度，因此其不易变形，并且对热冲击具有高耐久性。

公开(公告)号：US4849424A

公开(公告)日：1989-07-18

申请号：US82056

申请日：1987-08-05

申请人： Masazumi Ikeda ,  Susumu Okabe

发明人： Masazumi Ikeda ,  Susumu Okabe

IPC分类号： A61K31/50 ,  A61K31/505 ,  A61P1/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： The present invention relates to novel pyrimidine derivatives of the general formula ##STR1## wherein R.sup.1 represents a pyrazolyl, imidazolyl, or triazolyl group, R.sup.2 represents hydrogen atom or lower alkyl group, R.sup.3 represents a halo, amino, lower alkoxy, pyrazolyl, imidazolyl, triazolyl, piperidinyl, or aryloxy group, one of X or Y represents N and the other of X or Y represents CH, and the salts thereof.These derivatives may be used in the treatment of peptic ulcer disease.

摘要翻译： 本发明涉及通式“IMAGE”的新颖的嘧啶衍生物，其中R1代表吡唑基，咪唑基或三唑基，R2代表氢原子或低级烷基，R3代表卤素，氨基，低级烷氧基，吡唑基，咪唑基， 三唑基，哌啶基或芳氧基，X或Y之一表示N，X或Y中的另一个表示CH，及其盐。 这些衍生物可用于治疗消化性溃疡疾病。

公开(公告)号：US3988466A

公开(公告)日：1976-10-26

申请号：US555718

申请日：1975-03-06

申请人： Keijiro Takagi ,  Susumu Okabe

发明人： Keijiro Takagi ,  Susumu Okabe

IPC分类号： A61K31/405 ,  A61K31/40 ,  A61K31/195

CPC分类号： A61K31/621 ,  A61K31/405 ,  A61K31/60

摘要： Gastric lesions induced by anti-inflammatory agents such as aspirin and indomethacin are prevented by the administration of amino acids. An anti-inflammatory composition comprising an anti-inflammatory agent and an amino acid is useful in the treatment of inflammation without inducing the gastric lesions.

摘要翻译： 通过给予氨基酸可以防止由抗炎剂如阿司匹林和吲哚美辛诱导的胃损伤。 包含抗炎剂和氨基酸的抗炎组合物可用于治疗炎症而不诱导胃损伤。

公开(公告)号：US20110170832A1

公开(公告)日：2011-07-14

申请号：US12983984

申请日：2011-01-04

申请人： Sawako Yamai ,  Susumu Okabe ,  Tsuyoshi Ito ,  Kota Asaka ,  Koji Kitahara ,  Toshio Ishikawa

发明人： Sawako Yamai ,  Susumu Okabe ,  Tsuyoshi Ito ,  Kota Asaka ,  Koji Kitahara ,  Toshio Ishikawa

IPC分类号： G02B6/36 ,  B23P11/00

CPC分类号： G02B6/4246 ,  G02B6/4201 ,  G02B6/4261 ,  G02B6/428 ,  G02B6/4281 ,  G02B6/4283 ,  G02B6/4285 ,  Y10T29/49826

摘要： An optical transceiver module that is capable of being inserted into and removed from a cage includes a housing that houses a photoelectric conversion element, the housing having a guiding section formed along a front-rear direction, an operating lever that has an operating section and a lever-side contact section, the operating lever being attached to the housing in a rotatable manner about an axis of rotation; and a slider that has a wedge section that engages with a latching section provided to the cage, and a slider-side contact section that comes into contact with the lever-side contact section, the slider being guided in the front-rear direction by the guiding section, the lever-side contact section being located opposite the operating section with respect to the axis of rotation, and as the operating section is pushed rearward, the lever-side contact section pushes the slider-side contact section forward and the slider moves forward to a position where the wedge section is unlatched from the latching section.

摘要翻译： 能够插入到笼中并从笼中移除的光收发器模块包括容纳光电转换元件的壳体，壳体具有沿前后方向形成的引导部分，操作杆具有操作部分和 杠杆侧接触部分，操作杆以围绕旋转轴线的可旋转方式附接到壳体; 以及滑块，其具有与设置在所述保持架上的闩锁部分接合的楔形部分，以及与所述杠杆侧接触部分接触的滑块侧接触部分，所述滑块在前后方向上被引导 引导部，所述杆侧接触部相对于所述旋转轴线位于所述操作部的相对侧，并且当所述操作部被向后推时，所述杆侧接触部将所述滑块侧接触部向前方推动，并且所述滑块移动 前进到楔形部分从闩锁部分解锁的位置。

公开(公告)号：US06239051B1

公开(公告)日：2001-05-29

申请号：US09493017

申请日：2000-01-28

申请人： Fumito Tanaka ,  Hideya Sato ,  Susumu Okabe ,  Masaharu Yamada

发明人： Fumito Tanaka ,  Hideya Sato ,  Susumu Okabe ,  Masaharu Yamada

IPC分类号： C04B3504

CPC分类号： C04B35/053 ,  B22D41/02 ,  B22D41/54

摘要： The present invention provides a magnesia-spinel refractory in which corrosion resistance and slag penetration resistance are significantly improved. The magnesia-spinel refractory is obtained by mixing magnesia granulated powder having a particle diameter of 10 to 150 &mgr;m and alumina powder having a particle diameter of 0.1 to 5 &mgr;m, molding the resultant mixture, and then burning the molded product to form a dense and strong combined structure of periclase and spinel. The mixture of magnesia and alumina contains powders of both components, or a powder of one of the components and a granulated powder of the other component. It is preferable to use a spray dryer method as granulating means, and a hydrostatic pressing method as molding means. These mixtures are used for producing magnesia-spinel protecting tube and crucible, bricks for copper smelting and converting furnaces, and magnesia-spinel protecting tube and crucible for copper smelting and converting furnace slag. In this case, the hydrostatic pressing method is used.

摘要翻译： 本发明提供了耐腐蚀性和耐熔渣渗透性显着提高的氧化镁 - 尖晶石耐火材料。 通过混合粒径为10〜150μm的氧化镁粒状粉末和粒径为0.1〜5μm的氧化铝粉末，将所得混合物成型，然后将成型体燃烧形成致密的和 强韧组合结构的尖晶石和尖晶石。 氧化镁和氧化铝的混合物含有两种组分的粉末，或其中一种组分的粉末和另一种组分的造粒粉末。 优选使用喷雾干燥法作为造粒机构，以静压压制法作为成型机构。 这些混合物用于生产氧化镁 - 尖晶石保护管和坩埚，用于铜冶炼和转炉的砖，以及用于铜冶炼和转炉炉渣的氧化镁 - 尖晶石保护管和坩埚。 在这种情况下，使用静压法。

公开(公告)号：US5180836A

公开(公告)日：1993-01-19

申请号：US786392

申请日：1991-11-01

申请人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

发明人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

IPC分类号： C07D233/84 ,  C07D235/28

CPC分类号： C07D233/84 ,  C07D235/28

摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

摘要翻译： 公开了具有下式的新的咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或者R 1和R 2结合形成杂环; R3，R4，R5和R6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基或氟取代的 - 烷氧基，或R3与R2结合形成杂环; R8和R9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基，氟取代的 - 烷氧基或芳基，或R8和R9组合形成脂环 ; R 7是，其中R 8和R 9不组合，其中R 8和R 9结合，可以具有取代基的烷基，可以具有取代基的芳基，可以具有取代基的芳基或含硫 杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

公开(公告)号：US5082943A

公开(公告)日：1992-01-21

申请号：US658424

申请日：1991-02-20

申请人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

发明人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

IPC分类号： A61K31/415 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/47 ,  A61P1/04 ,  C07D233/84 ,  C07D233/86 ,  C07D233/88 ,  C07D233/90 ,  C07D233/92 ,  C07D235/28 ,  C07D401/12

CPC分类号： C07D235/28 ,  C07D233/84

摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

公开(公告)号：US08967229B2

公开(公告)日：2015-03-03

申请号：US13878247

申请日：2011-01-28

申请人： Susumu Okabe ,  Masanori Sato ,  Masashi Takahashi ,  Tsuyoshi Nanba

发明人： Susumu Okabe ,  Masanori Sato ,  Masashi Takahashi ,  Tsuyoshi Nanba

IPC分类号： B22C9/02 ,  B22C15/00 ,  B22C9/04 ,  B22C7/02 ,  B22C9/18 ,  B22D25/02

CPC分类号： B22C9/046 ,  B22C7/026 ,  B22C9/18 ,  B22D25/02 ,  Y10T29/49826

摘要： An evaporative pattern casting method is taught which does not reduce accuracy of an evaporative pattern.The evaporative pattern casting method comprises a part manufacturing process (S2), an assembly process (S4), a sand mold manufacturing process (S6), a molten metal pouring process (S8) and a sand removal process (S12). In the part manufacturing process, the evaporative pattern is manufactured as a plurality of separate parts. In the assembly process, the parts are assembled on a work plane. In the sand mold manufacturing process, the evaporative pattern is covered with sand to form a sand mold without moving the assembled evaporative pattern from the work plane. In the molten metal pouring process, molten metal is poured into the sand mold. In the sand removal process, the sand is removed after the molten metal has solidified. According to this casting method, the sand mold is formed without moving the assembled evaporative pattern from the work plane, and consequently the accuracy of the dimensions at the time of assembly can be maintained.

摘要翻译： 教导了不降低蒸发图案的精度的蒸发图案铸造方法。 蒸发图案铸造方法包括零件制造工艺（S2），组装工艺（S4），砂模制造工艺（S6），熔融金属浇注工艺（S8）和除砂工艺（S12）。 在部件制造过程中，蒸发图案被制造为多个分开的部件。 在组装过程中，零件被组装在工作平面上。 在砂模制造过程中，蒸发图案用砂覆盖以形成砂模，而不将组装的蒸发图案从工作平面移动。 在熔融金属浇注过程中，将熔融金属倒入砂模中。 在除砂过程中，在熔融金属固化后除去砂。 根据该铸造方法，形成砂模，而不将组装的蒸发图案从工作平面移动，因此可以保持组装时的尺寸精度。

公开(公告)号：US20130292080A1

公开(公告)日：2013-11-07

申请号：US13878247

申请日：2011-01-28

申请人： Susumu Okabe ,  Masanori Sato ,  Masashi Takahashi ,  Tsuyoshi Nanba

发明人： Susumu Okabe ,  Masanori Sato ,  Masashi Takahashi ,  Tsuyoshi Nanba

IPC分类号： B22C9/04

CPC分类号： B22C9/046 ,  B22C7/026 ,  B22C9/18 ,  B22D25/02 ,  Y10T29/49826

摘要： An evaporative pattern casting method is taught which does not reduce accuracy of an evaporative pattern.The evaporative pattern casting method comprises a part manufacturing process (S2), an assembly process (S4), a sand mold manufacturing process (S6), a molten metal pouring process (S8) and a sand removal process (S12). In the part manufacturing process, the evaporative pattern is manufactured as a plurality of separate parts. In the assembly process, the parts are assembled on a work plane. In the sand mold manufacturing process, the evaporative pattern is covered with sand to form a sand mold without moving the assembled evaporative pattern from the work plane. In the molten metal pouring process, molten metal is poured into the sand mold. In the sand removal process, the sand is removed after the molten metal has solidified. According to this casting method, the sand mold is formed without moving the assembled evaporative pattern from the work plane, and consequently the accuracy of the dimensions at the time of assembly can be maintained.

摘要翻译： 教导了不降低蒸发图案的精度的蒸发图案铸造方法。 蒸发图案铸造方法包括零件制造工艺（S2），组装工艺（S4），砂模制造工艺（S6），熔融金属浇注工艺（S8）和除砂工艺（S12）。 在部件制造过程中，蒸发图案被制造为多个分开的部件。 在组装过程中，零件被组装在工作平面上。 在砂模制造过程中，蒸发图案用砂覆盖以形成砂模，而不将组装的蒸发图案从工作平面移动。 在熔融金属浇注过程中，将熔融金属倒入砂模中。 在除砂过程中，在熔融金属固化后除去砂。 根据该铸造方法，形成砂模，而不将组装的蒸发图案从工作平面移动，因此可以保持组装时的尺寸精度。

公开(公告)号：US4824856A

公开(公告)日：1989-04-25

申请号：US896154

申请日：1986-08-13

申请人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

发明人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

IPC分类号： A61K31/445 ,  C07D235/28 ,  A61K31/415

CPC分类号： C07D235/28 ,  A61K31/445

摘要： A method of protecting gastrointestinal tract in a mammal from the untoward, non-gastric-acid-induced effects of exposure to gastrointestinally injuruous agents, which comprises administering orally to said mammal a non-antisecretory amount of a benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is the hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group, phenyl group or aralkyl group, R.sup.2 is the hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom forms a ring, and each of R.sup.3 and R.sup.4 independently is the hydrogen atom, a halogen atom, the trifluoromethyl group, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group.

摘要翻译： 一种保护哺乳动物胃肠道免受暴露于胃肠损伤药物的非胃酸，非胃酸诱导作用的方法，其包括向所述哺乳动物口服给予非抗分泌量的式（I）的苯并咪唑衍生物， ：其中R 1为氢原子，碳原子数为1〜8的烷基，环烷基，苯基或芳烷基，R 2为氢原子或低级烷基，或者R 1和R 2为一体 与相邻的氮原子形成环，R3和R4各自独立地为氢原子，卤素原子，三氟甲基，低级烷基，低级烷氧基，低级烷氧基羰基或氨基。