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1.发明授权Method for identifying agents which modulate chemokine “MEC”-induced functions of CCR3 失效用于鉴定调节趋化因子“MEC”诱导CCR3功能的药剂的方法公开(公告)号：US06692922B2
公开(公告)日：2004-02-17
申请号：US09931381
申请日：2001-08-15
IPC分类号： G01N3353
CPC分类号： G01N33/6863 , A61K2039/505 , C07K14/523
摘要： The invention relates to the interaction of MEC with CCR3 and/or CCR10 and to agents (e.g., ligands, antibodies, antagonists, agonists, inhibitors, promoters) which alter said interaction. In one aspect, the invention relates to methods for detecting or identifying an agent (i.e., molecule or compound) which can modulate (inhibit, promote) the binding of MEC to CCR3 and/or CCR10. In another aspect, the invention relates to a method of treating a subject having an inflammatory condition, comprising administering to the subject an effective amount of an agent which modulates the binding of MEC to CCR3 and/or CCR10.
摘要翻译： 本发明涉及MEC与CCR3和/或CCR10的相互作用以及改变所述相互作用的试剂（例如配体，抗体，拮抗剂，激动剂，抑制剂，启动子）。 一方面，本发明涉及用于检测或鉴定可以调节（抑制，促进）MEC与CCR3和/或CCR10的结合的试剂（即分子或化合物）的方法。 另一方面，本发明涉及治疗患有炎性病症的受试者的方法，其包括向所述受试者施用有效量的调节MEC与CCR3和/或CCR10结合的药剂。
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2.发明申请公开(公告)号：US20090304769A1
公开(公告)日：2009-12-10
申请号：US12302756
申请日：2007-06-04
IPC分类号： A61F2/06 , A61K31/519 , A61K31/47 , A61K31/122 , A61K31/44 , A61K31/496 , A61K31/135 , A61K31/085 , A61P9/00
CPC分类号： C12Q1/02 , A61K31/13 , A61K31/135 , A61K31/4706 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/565 , A61K45/06 , A61L31/16 , G01N33/5061 , G01N33/5064 , G01N2800/323
摘要： Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
摘要翻译： 通过在一组测定中测定测试剂来测定抑制或预防再狭窄的药剂，以测量测试剂对细胞增殖，血栓形成，组织造型和炎症的影响。 使用本发明的组合物提供再狭窄的治疗。
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3.发明申请METHODS FOR IDENTIFYING AGENTS AND THEIR USE FOR THE PREVENTION OR STABILIZATION OF FIBROSIS 审中-公开鉴别药物的方法及其用于预防或稳定纤维化的用途公开(公告)号：US20100093613A1
公开(公告)日：2010-04-15
申请号：US12530582
申请日：2008-03-10
IPC分类号： C12Q1/68 , C12Q1/02 , A61K31/4184 , A61K31/44 , A61K31/335 , A61K38/12 , A61K31/343 , A61K31/352 , A61K31/196 , A61K31/50 , A61P21/00
CPC分类号： G01N33/6893 , G01N33/5055 , G01N33/5064 , G01N33/5067 , G01N2800/085 , G01N2800/10 , G01N2800/382
摘要： Agents that stabilize and/or prevent fibrosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on matrix deposition and remodeling, epithelial health, and inflammation. Treatment for fibrosis is provided using compositions of the invention.
摘要翻译： 稳定和/或预防纤维化的药物通过在测定电池中测定试剂来测定测试剂对基质沉积和重塑，上皮健康和炎症的影响来鉴定。 使用本发明的组合物提供纤维化的治疗。
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公开(公告)号：US20110144134A1
公开(公告)日：2011-06-16
申请号：US13018337
申请日：2011-01-31
IPC分类号： A61K31/519 , C07D487/04 , A61P29/00 , A61P31/00 , A61P9/00 , A61P35/00 , A61P3/04 , A61P3/10 , A61P1/00 , A61P17/06 , A61P19/02 , A61P11/06 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
摘要翻译： 本发明提供了抗炎化合物，其可用于治疗疾病进展中发生炎症或疾病或病症症状的疾病和病症。
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公开(公告)号：US20090124638A1
公开(公告)日：2009-05-14
申请号：US11719722
申请日：2005-11-21
IPC分类号： A61K31/519 , C07D487/04 , A61P3/10 , A61P1/00 , A61P17/06 , A61P19/02 , A61P11/06 , A61P9/10
CPC分类号： C07D487/04
摘要： The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
摘要翻译： 本发明提供了抗炎化合物，其可用于治疗疾病进展中发生炎症或疾病或病症症状的疾病和病症。
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公开(公告)号：US09734282B2
公开(公告)日：2017-08-15
申请号：US11910200
申请日：2006-03-28
申请人： Jennifer Melrose , Elen Rosler , Melissa Fischer , Sylvie Privat , Eric J. Kunkel , Ellen Berg
发明人： Jennifer Melrose , Elen Rosler , Melissa Fischer , Sylvie Privat , Eric J. Kunkel , Ellen Berg
CPC分类号： G06F19/18 , G06F19/12 , G06F19/24 , G06F19/704
摘要： Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
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公开(公告)号：US08019551B2
公开(公告)日：2011-09-13
申请号：US10590751
申请日：2005-02-17
申请人： Elen S. Rosler , Eric J. Kunkel , Sylvie Privat , Jennifer Melrose , Melissa Fischer , Ellen L. Berg
发明人： Elen S. Rosler , Eric J. Kunkel , Sylvie Privat , Jennifer Melrose , Melissa Fischer , Ellen L. Berg
IPC分类号： G06F7/00
CPC分类号： G01N33/5008 , G01N33/5023 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5061 , G01N2800/122 , G06F19/20 , G06F19/706
摘要： Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
摘要翻译： 提供了用于评估与哮喘和其他特应性病症相关的生物数据集概况的方法和系统，其中比较和鉴定了包含多个细胞参数的信息的数据集，并用于评估作为治疗剂的适合性的候选药理学试剂。
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8.发明申请BIOLOGICAL DATASET PROFILING OF CARDIOVASCULAR DISEASE AND CARDIOVASCULAR INFLAMMATION 有权心血管疾病的生物数据分布和心脏血管炎公开(公告)号：US20090118133A1
公开(公告)日：2009-05-07
申请号：US11910200
申请日：2006-03-28
申请人： Jennifer Melrose , Elen Rosler , Melissa Fischer , Sylvie Privat , Eric J. Kunkel , Ellen Berg
发明人： Jennifer Melrose , Elen Rosler , Melissa Fischer , Sylvie Privat , Eric J. Kunkel , Ellen Berg
IPC分类号： C40B30/02
CPC分类号： G06F19/18 , G06F19/12 , G06F19/24 , G06F19/704
摘要： Methods and systems for evaluating biological dataset profiles relating to inflammatory cardiovascular conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.
摘要翻译： 提供了用于评估与炎性心血管病症相关的生物数据集概况的方法和系统，其中比较和鉴定了包含多个细胞参数的信息的数据集，并用于评价作为治疗剂的适合性的候选药理学试剂。
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![Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents](/abs-image/US/2016/12/06/US09512125B2/abs.jpg.150x150.jpg)
公开(公告)号：US09512125B2
公开(公告)日：2016-12-06
申请号：US11719722
申请日：2005-11-21
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P9/00 , A61P19/02 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P9/10
CPC分类号： C07D487/04
摘要： The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
摘要翻译： 本发明提供了抗炎化合物，其可用于治疗疾病进展中发生炎症或疾病或病症症状的疾病和病症。
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10.发明授权Methods for identifying agents and their use for the prevention of restenosis 有权识别药剂的方法及其用于预防再狭窄的用途公开(公告)号：US08697387B2
公开(公告)日：2014-04-15
申请号：US12302756
申请日：2007-06-04
CPC分类号： C12Q1/02 , A61K31/13 , A61K31/135 , A61K31/4706 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/565 , A61K45/06 , A61L31/16 , G01N33/5061 , G01N33/5064 , G01N2800/323
摘要： Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
摘要翻译： 通过在一组测定中测定测试剂来测定抑制或预防再狭窄的药剂，以测量测试剂对细胞增殖，血栓形成，组织造型和炎症的影响。 使用本发明的组合物提供再狭窄的治疗。
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