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公开(公告)号：US07649082B2
公开(公告)日：2010-01-19
申请号：US11037782
申请日：2005-01-18
申请人： Eugene M. Johnson , Jeffrey D. Milbrandt , Paul T. Kotzbauer , Patricia A. Lampe , Robert D. Klein , Frederic J. de Sauvage
发明人： Eugene M. Johnson , Jeffrey D. Milbrandt , Paul T. Kotzbauer , Patricia A. Lampe , Robert D. Klein , Frederic J. de Sauvage
IPC分类号： C07K16/22
CPC分类号： G01N33/5008 , A61K38/00 , A61K48/00 , C07K14/475 , C07K16/22 , C07K2319/00 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N2333/4756
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了人，小鼠和大鼠的氨基酸序列。 已经克隆并测序了人，小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US06692943B1
公开(公告)日：2004-02-17
申请号：US09220527
申请日：1998-12-24
IPC分类号： C12P2104
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US06403335B1
公开(公告)日：2002-06-11
申请号：US09128026
申请日：1998-07-31
IPC分类号： C12N1518
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US06232449B1
公开(公告)日：2001-05-15
申请号：US08981739
申请日：1998-08-31
IPC分类号： C07K1448
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US6090778A
公开(公告)日：2000-07-18
申请号：US775414
申请日：1996-12-31
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61K48/00 , A61P7/00 , A61P7/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , C07K14/475 , C07K14/52 , C07K19/00 , C12N20060101 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/16 , C12P19/34 , C12P21/02 , C12Q1/68 , C07K14/00 , C07K14/435
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00
摘要： A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了一种新的生长因子neurturin。 人和小鼠的氨基酸序列已被鉴定。 已经克隆了人和小鼠neurturin基因组DNA序列，并鉴定了序列和各自的cDNA序列。 还公开了亚克隆到载体中以及用载体稳定转化的细胞的制备。 另外，提供了使用neurturin治疗退行性疾病的方法，用于检测基因改变的方法以及用于检测和监测neurturin患者水平的方法。 还提供了用于鉴定生长因子的neurturin-GDNF家族的其他成员的方法。
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公开(公告)号：US06743628B1
公开(公告)日：2004-06-01
申请号：US09219952
申请日：1998-12-23
IPC分类号： C12N502
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00
摘要： A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective CDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了一种新的生长因子neurturin。 人和小鼠的氨基酸序列已被鉴定。 已经克隆了人和小鼠neurturin基因组DNA序列，并鉴定了序列和相应的CDNA序列。 还公开了亚克隆到载体中以及用载体稳定转化的细胞的制备。 另外，提供了使用neurturin治疗退行性病症的方法，用于检测基因改变的方法以及用于检测和监测neurturin患者水平的方法。 还提供了用于鉴定生长因子的neurturin-GDNF家族的其他成员的方法。
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公开(公告)号：US06645937B1
公开(公告)日：2003-11-11
申请号：US09220616
申请日：1998-12-24
IPC分类号： A61K3818
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了小鼠和大鼠的氨基酸序列。 已经克隆并测序了小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US5739307A
公开(公告)日：1998-04-14
申请号：US519777
申请日：1995-08-28
IPC分类号： G01N33/53 , A61K31/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61K48/00 , A61P7/00 , A61P7/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , C07K14/475 , C07K14/52 , C07K19/00 , C12N20060101 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/16 , C12P19/34 , C12P21/02 , C12Q1/68 , C12N15/63 , C12P21/00
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00
摘要： A novel growth factor, neurturin, is disclosed. The human and mouse amino acid sequences have been identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequences and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors is also disclosed. In addition, methods for treating degenerative conditions using neurturin, methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了一种新的生长因子neurturin。 人和小鼠的氨基酸序列已被鉴定。 已经克隆了人和小鼠neurturin基因组DNA序列，并鉴定了序列和各自的cDNA序列。 还公开了亚克隆到载体中以及用载体稳定转化的细胞的制备。 另外，提供了使用neurturin治疗退行性疾病的方法，用于检测基因改变的方法以及用于检测和监测neurturin患者水平的方法。 还提供了用于鉴定生长因子的neurturin-GDNF家族的其他成员的方法。
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9.发明授权公开(公告)号：US07015316B1
公开(公告)日：2006-03-21
申请号：US09220617
申请日：1998-12-24
申请人： Eugene M. Johnson , Jeffrey D. Milbrandt , Paul T. Kotzbauer , Patricia A. Lampe , Robert Klein , Fred DeSauvage
发明人： Eugene M. Johnson , Jeffrey D. Milbrandt , Paul T. Kotzbauer , Patricia A. Lampe , Robert Klein , Fred DeSauvage
IPC分类号： C12N15/18
CPC分类号： G01N33/5008 , A61K38/00 , A61K48/00 , C07K14/475 , C07K16/22 , C07K2319/00 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N2333/4756
摘要： A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using persephin, methods for detecting persephin gene alterations and methods for detecting and monitoring patient levels of persephin are provided. Methods for identifying additional members of the persephin-neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了属于GDNF / neurturin生长因子家族的新生长因子persephin。 已经鉴定了人，小鼠和大鼠的氨基酸序列。 已经克隆并测序了人，小鼠和大鼠persephin基因组DNA序列，并鉴定了各自的cDNA序列。 此外，还提供了使用persephin治疗退行性病症的方法，用于检测persephin基因改变的方法以及用于检测和监测患者血浆含量的方法。 还提供了用于鉴定生长因子的persephin-neurturin-GDNF家族的额外成员的方法。
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公开(公告)号：US07015311B1
公开(公告)日：2006-03-21
申请号：US09476290
申请日：1999-12-30
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00
摘要： A novel growth factor, neurturin, is disclosed and the human and mouse amino acid sequences are identified. Human and mouse neurturin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. The subcloning into vectors and the preparation of cells stably transformed with the vectors are also disclosed. In addition, methods for treating degenerative conditions, tumor cells and obesity; methods for detecting gene alterations and methods for detecting and monitoring patient levels of neurturin are provided. Methods for identifying additional members of the neurturin-GDNF family of growth factors are also provided.
摘要翻译： 公开了一种新的生长因子neurturin，并鉴定了人和小鼠的氨基酸序列。 已经克隆并测序了人和小鼠neurturin基因组DNA序列，并鉴定了各自的cDNA序列。 还公开了亚克隆入载体和用载体稳定转化的细胞的制备。 此外，治疗退行性疾病，肿瘤细胞和肥胖症的方法; 提供了检测基因改变的方法和检测和监测neurturin患者水平的方法。 还提供了用于鉴定生长因子的neurturin-GDNF家族的其他成员的方法。
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