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    Methods and compositions to treat myocardial conditions
    1.
    发明授权
    Methods and compositions to treat myocardial conditions 有权
    治疗心肌病症的方法和组合物

    公开(公告)号：US08821473B2

    公开(公告)日：2014-09-02

    申请号：US12632612

    申请日：2009-12-07

    申请人： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    发明人： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    IPC分类号： A61M31/00 ,  A61K31/7088 ,  A61K9/00

    CPC分类号： A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

    摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

    摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

    METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS
    6.
    发明申请
    METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS 失效
    治疗肌肉条件的方法和组合

    公开(公告)号：US20120219521A1

    公开(公告)日：2012-08-30

    申请号：US13468956

    申请日：2012-05-10

    申请人： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatia ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    发明人： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatia ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    IPC分类号： A61K31/765 ,  A61M25/00

    CPC分类号： A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

    摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

    摘要翻译： 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

    Device and method for combining a treatment agent and a gel
    10.
    发明授权
    Device and method for combining a treatment agent and a gel 有权
    用于组合处理剂和凝胶的装置和方法

    公开(公告)号：US08637069B2

    公开(公告)日：2014-01-28

    申请号：US13559423

    申请日：2012-07-26

    申请人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    发明人： Charles D. Claude ,  Paul J. Kawula ,  Syed Faiyaz Ahmed Hossainy ,  Kimchi Tran

    IPC分类号： A61F13/00

    CPC分类号： A61K9/0024 ,  A61K9/06

    摘要： A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.

    摘要翻译： 一种方法，包括在哺乳动物宿主内的处理部位引入处理剂; 并在处理部位引入可生物浸渍的凝胶材料。 一种包括第一环形构件的装置，所述第一环形构件具有围绕所述第一环形构件的长度设置的第一腔和在所述第一环形构件的近端处的第一入口，以及联接到所述第一环形构件的第二环形构件，所述第二环形构件具有第二内腔 设置在所述第二环形构件的大约一定长度处和在所述第二环形构件的近端处的第二入口，其中所述第一环形构件和所述第二环形构件被定位成允许通过每个环形构件引入的处理剂在 治疗部位。