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    DIFFERENTIAL EXCITATION SPECTROSCOPY
    1.
    发明申请
    DIFFERENTIAL EXCITATION SPECTROSCOPY 有权
    差异激发光谱

    公开(公告)号：US20150069258A1

    公开(公告)日：2015-03-12

    申请号：US14473796

    申请日：2014-08-29

    申请人： Eugene W. Butler ,  Timothy M. Stratman ,  Boyd V. Hunter ,  Paul Harrison ,  Jason M. Cox

    发明人： Eugene W. Butler ,  Timothy M. Stratman ,  Boyd V. Hunter ,  Paul Harrison ,  Jason M. Cox

    IPC分类号： G01N21/62 ,  G01N22/00 ,  G01N21/27

    CPC分类号： G01N21/35 ,  G01N21/031 ,  G01N21/27 ,  G01N21/3581 ,  G01N21/636 ,  G01N22/00 ,  G01N2021/3125

    摘要： A new technique which uses a pump-probe methodology to place a molecule into one or more excited rotational and/or vibrational states. By evaluating spectral changes due to at least one discrete frequency of pump photons a multi-dimensional characterization of the molecule's excited state energy level results. This multi-dimensional characterization typically involves evaluating the changes between excited and unexcited state measurements. The differential nature of the evaluation makes the technique self-referencing and solves problems common to many spectroscopic techniques. The multi-dimensionality of the technique provides high specificity and immunity to interferents. The preferred embodiments involve excitation by using photons suited to pumping the rotational states and evaluating the effects by probing the energy levels of one of more vibrational states. The technique is capable of detecting bulk and trace concentrations of a molecule in gas, liquid and solid phases, both in pure form and in the presence of other molecules.

    摘要翻译： 一种使用泵浦探针方法将分子置于一个或多个激发的旋转和/或振动状态的新技术。 通过评估由于至少一个离散频率的泵浦光子的光谱变化，可以得到分子激发态能级的多维表征。 这种多维表征通常包括评估激发态和不精确状态测量之间的变化。 评估的差异性使得技术自我参照并且解决了许多光谱技术常见的问题。 该技术的多维度为干扰物提供了高度的特异性和免疫性。 优选实施例涉及通过使用适于泵送旋转状态的光子并通过探测更多振动状态之一的能量水平来评估效果来激发。 该技术能够检测气体，液体和固相中分子的体积和痕量浓度，无论是纯形式还是在其它分子存在下。

    Differential excitation spectroscopy
    2.
    发明授权
    Differential excitation spectroscopy 有权
    差分激发光谱

    公开(公告)号：US09395311B2

    公开(公告)日：2016-07-19

    申请号：US14473796

    申请日：2014-08-29

    申请人： Eugene W. Butler ,  Timothy M. Stratman ,  Boyd V. Hunter ,  Paul Harrison ,  Jason M. Cox

    发明人： Eugene W. Butler ,  Timothy M. Stratman ,  Boyd V. Hunter ,  Paul Harrison ,  Jason M. Cox

    IPC分类号： G01N21/27 ,  G01N22/00 ,  G01N21/35 ,  G01N21/31

    CPC分类号： G01N21/35 ,  G01N21/031 ,  G01N21/27 ,  G01N21/3581 ,  G01N21/636 ,  G01N22/00 ,  G01N2021/3125

    摘要： A new technique which uses a pump-probe methodology to place a molecule into one or more excited rotational and/or vibrational states. By evaluating spectral changes due to at least one discrete frequency of pump photons a multi-dimensional characterization of the molecule's excited state energy level results. This multi-dimensional characterization typically involves evaluating the changes between excited and unexcited state measurements. The differential nature of the evaluation makes the technique self-referencing and solves problems common to many spectroscopic techniques. The multi-dimensionality of the technique provides high specificity and immunity to interferents. The preferred embodiments involve excitation by using photons suited to pumping the rotational states and evaluating the effects by probing the energy levels of one of more vibrational states. The technique is capable of detecting bulk and trace concentrations of a molecule in gas, liquid and solid phases, both in pure form and in the presence of other molecules.

    摘要翻译： 一种使用泵浦探针方法将分子置于一个或多个激发的旋转和/或振动状态的新技术。 通过评估由于至少一个离散频率的泵浦光子的光谱变化，可以得到分子激发态能级的多维表征。 这种多维表征通常包括评估激发态和不精确状态测量之间的变化。 评估的差异性使得技术自我参照并且解决了许多光谱技术常见的问题。 该技术的多维度为干扰物提供了高度的特异性和免疫性。 优选实施例涉及通过使用适于泵送旋转状态的光子并通过探测更多振动状态之一的能量水平来评估效果来激发。 该技术能够检测气体，液体和固相中分子的体积和痕量浓度，无论是纯形式还是在其它分子存在下。

    Tricyclic heteroaromatic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
    6.
    发明授权
    Tricyclic heteroaromatic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权
    三环杂芳族化合物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US07855206B2

    公开(公告)日：2010-12-21

    申请号：US12513190

    申请日：2007-11-09

    申请人： Jason M. Cox ,  Hong Dong

    发明人： Jason M. Cox ,  Hong Dong

    IPC分类号： A01N43/54 ,  A01N43/66 ,  A01N43/58 ,  A01N43/60 ,  A01N43/64 ,  A61K31/50 ,  A61K31/505 ,  A61K31/495 ,  A61K31/53 ,  C07D471/00 ,  C07D487/00 ,  C07D251/00

    CPC分类号： C07D487/14

    摘要： The present invention is directed to novel substituted tricyclic heteroaromatic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及结构式（I）的新型取代三环杂芳族化合物，其为二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

    Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes
    7.
    发明申请
    Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes 有权
    融合氨基哌啶作为二肽基肽酶-4抑制剂治疗或预防糖尿病

    公开(公告)号：US20090233936A1

    公开(公告)日：2009-09-17

    申请号：US12085797

    申请日：2006-12-08

    申请人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    发明人： Jason M. Cox ,  Scott D. Edmondson ,  Anthony Mastracchio

    IPC分类号： A61K31/4985 ,  C07D471/12 ,  A61K31/4375 ,  C07D487/12 ,  A61K31/519 ,  A61K31/5025 ,  A61P3/10

    CPC分类号： C07D471/14

    摘要： The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.

    摘要翻译： 本发明涉及结构式（I）的新型取代的稠合氨基哌啶，其是二肽基肽酶-4酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-4酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-4酶的疾病中的用途。

    Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
    10.
    发明授权
    Aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权
    氨基哌啶作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病

    公开(公告)号：US07884104B2

    公开(公告)日：2011-02-08

    申请号：US11662064

    申请日：2005-09-27

    申请人： Jason M. Cox ,  Scott D. Edmondson ,  Bart Harper ,  Ann E. Weber

    发明人： Jason M. Cox ,  Scott D. Edmondson ,  Bart Harper ,  Ann E. Weber

    IPC分类号： A61K31/4545 ,  C07D487/04

    CPC分类号： C07D401/04 ,  C07D471/04 ,  C07D487/04

    摘要： The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新的取代的氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。