公开(公告)号：US20110306513A1

公开(公告)日：2011-12-15

申请号：US13139095

申请日：2009-12-03

申请人： Eun Young Song ,  Hee Gu Lee ,  Young II Yeom ,  Na Young Ji ,  Jung II Lee ,  Min A. Kang ,  Young Joo Kim ,  Yoon Hee Kang ,  Jae Wha Kim

发明人： Eun Young Song ,  Hee Gu Lee ,  Young II Yeom ,  Na Young Ji ,  Jung II Lee ,  Min A. Kang ,  Young Joo Kim ,  Yoon Hee Kang ,  Jae Wha Kim

IPC分类号： C40B30/04 ,  C40B40/10 ,  C12Q1/68 ,  C07K16/40 ,  G01N33/577 ,  C07H21/00 ,  C07K16/18 ,  C07K16/24 ,  C40B40/06 ,  G01N33/574

CPC分类号： G01N33/5023 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57438

摘要： The present invention relates to the elucidation of a gene that can act as a novel marker for liver cancer diagnosis and to diagnostic and prognostic measurements of liver cancer using the same. More specifically, it relates to a diagnosis kit that enables diagnostic and prognostic measurement of a liver cancer using a preparation that measures expression levels of at least one gene selected from a group of liver cancer diagnosis markers consisting of S100P, NK4, CCL20, CSPG2, PLAU, MMP12, ESM-1, ABHD7, HCAPG, CXCL-3, Col5A2, MAGEA, GSN, CDC2, CST1, MELK, ATAD2, FAP and MSN and/or a method for diagnostic and prognostic measurement of liver cancer using the same. These have been discovered using normal liver tissues and liver cancer tissues collected from the same liver cancer patient of the present invention and represent the markers whose accuracy and reliability have been greatly improved as markers of liver cancer. The markers of the present invention can be used for the accurate diagnosis and prognosis of liver cancer.

摘要翻译： 本发明涉及可以作为肝癌诊断的新型标志物的基因的阐明，以及使用该基因的肝癌的诊断和预后测定。 更具体地说，本发明涉及能够使用测定从S100P，NK4，CCL20，CSPG2等组成的肝癌诊断标志物组中选出的至少一种基因的表达量的制剂的肝癌的诊断和预后测定的诊断试剂盒， PLAU，MMP12，ESM-1，ABHD7，HCAPG，CXCL-3，Col5A2，MAGEA，GSN，CDC2，CST1，MELK，ATAD2，FAP和MSN和/或使用其进行肝癌的诊断和预后测量的方法。 使用从本发明的同一肝癌患者收集的正常肝组织和肝癌组织已经发现了这些，并且其标志物的准确性和可靠性已经作为肝癌的标志物而大大改善。 本发明的标记物可用于肝癌的准确诊断和预后。

公开(公告)号：US20100248244A1

公开(公告)日：2010-09-30

申请号：US12744223

申请日：2007-11-23

申请人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

发明人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07K16/18 ,  G01N33/48 ,  G01N33/53 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.

摘要翻译： 本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。 还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。