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14 条记录 (耗时 0.053 秒)

    G protein coupled receptor protein and use thereof
    6.
    发明授权
    G protein coupled receptor protein and use thereof 有权
    G蛋白偶联受体蛋白及其用途

    公开(公告)号：US09034327B2

    公开(公告)日：2015-05-19

    申请号：US13322304

    申请日：2009-09-07

    申请人： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    发明人： Kyung Sook Chung ,  Mi Sun Won ,  Ji Won Ahn ,  Jeong Hae Choi ,  Hyang Sook Yoo ,  Young Il Yeom ,  Eun Young Song ,  Hee Gu Lee ,  Jae Hun Cheong ,  Chang Mo Kang

    IPC分类号： G01N33/53 ,  C07K14/705 ,  G01N33/50

    CPC分类号： C07K14/705 ,  G01N33/5041

    摘要： Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

    摘要翻译： 公开了新型GPCR（G蛋白偶联受体）蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地，考虑了新型GPCR（G蛋白偶联受体）多肽，编码它的多核苷酸，携带多核苷酸或其片段的重组载体，用该载体转化的宿主细胞，用载体感染的转基因动物。 另外，含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂，癌症诊断用试剂盒，含有该组合物的检测癌标记物的组合物，以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外，用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法， 提供。

    Biomarkers Indicative of Colon Cancer and Metastasis and Diagnosis and Screening Therapeutics Using the Same
    7.
    发明申请
    Biomarkers Indicative of Colon Cancer and Metastasis and Diagnosis and Screening Therapeutics Using the Same 审中-公开
    指示结肠癌和转移的诊断和筛查治疗的生物标记物

    公开(公告)号：US20110201512A1

    公开(公告)日：2011-08-18

    申请号：US12822556

    申请日：2010-06-24

    申请人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

    发明人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

    IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/57419 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： The present invention relates to a method for detecting a colon cancer in a human, comprising the steps of: (a) providing a biological sample from the human; and (b) detecting the level of a ATAD2 nucleic acid or a ATAD2 protein in the biological sample, relative to the level of the ATAD2 nucleic acid or the ATAD2 protein in a control sample from a normal human, wherein an increased level of the ATAD2 nucleic acid or the ATAD2 protein in the biological sample compared to the control sample indicates that the human has the colon cancer. The biomarker of this invention was identified using normal colon tissue, colon cancer tissue and metastatic cancer tissue derived from a colon cancer patient. Therefore, the accuracy and reliability of the present biomarker for colon cancer and/or metastasis are much more significantly improved. In addition, the biomarker of this invention permits to identify and predict colon cancer or metastasis in an accurate manner.

    摘要翻译： 本发明涉及一种检测人类结肠癌的方法，包括以下步骤：（a）从人体提供生物样品; 相对于来自正常人的对照样品中的ATAD2核酸或ATAD2蛋白的水平，检测生物样品中ATAD2核酸或ATAD2蛋白的水平，其中ATAD2的升高水平 与对照样品相比，生物样品中的核酸或ATAD2蛋白表明人类具有结肠癌。 使用来自结肠癌患者的正常结肠组织，结肠癌组织和转移性癌组织鉴定本发明的生物标志物。 因此，目前用于结肠癌和/或转移的生物标志物的准确性和可靠性大大提高。 此外，本发明的生物标志物允许以准确的方式鉴定和预测结肠癌或转移。